EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

octocrylene
2-propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester

Supplier Sponsors

Name:2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate
CAS Number: 6197-30-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:228-250-8
FDA UNII:5A68WGF6WM
Nikkaji Web:J8.358E
MDL:MFCD00059260
XlogP3-AA:7.10 (est)
Molecular Weight:361.48459000
Formula:C24 H27 N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic UV absorber
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FCN 217 2-Cyano-3,3-diphenyl-2-propenoic acid 2-ethylhexyl ester View - notice
DG SANTE Food Contact Materials:2-cyano-3,3-diphenylacrylic acid 2-ethylhexyl ester
 
Physical Properties:
Appearance:yellow clear viscous liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: -10.00 °C. @ 760.00 mm Hg
Boiling Point: 218.00 °C. @ 1.50 mm Hg
Boiling Point: 478.00 to 479.00 °C. @ 760.00 mm Hg (est)
Flash Point: 463.00 °F. TCC ( 239.50 °C. ) (est)
logP (o/w): 6.893 (est)
Soluble in:
 alcohol
 water, 0.003808 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
uv filters
 
Suppliers:
American International Chemical, LLC.
Octocrylene USP
BOC Sciences
For experimental / research use only.
Octocrylene ò95%
Odor: characteristic
Use: Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics. Aromatics, Pharmaceuticals, Intermediates and Fine Chemicals,
Galaxy Surfactants
GalSORB Octocrylene
Jiangyin Healthway
2-Ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrylene)
New functional food ingredients
Mayzo
BLS 3039 Ultraviolet Absorber
Odor: characteristic
Use: BLS 3039 is a liquid cyanoacrylate-type UV absorber (UVA) used as a light stabilizer in plastics, adhesives, and coatings. The product is inherently non-discoloring and is also chemically non-interacting with reactive monomers and polymerization catalysts.
O'Laughlin Industries
HELIOSUN OCR USP
O'Laughlin Industries
HELIOSUN OCR
Penta International
OCTOCRYLENE USP
Sigma-Aldrich
For experimental / research use only.
Octocrylene
analytical standard
Symrise
Neo Heliopan® 303
Odor: characteristic
Use: Neo Heliopan® 303 is an effective oil-soluble UVB absorber offering additional absorption in the short-wave UVA spectrum. Maximum absorption is at 303nm.
TRI-K Industries
GalSorb Octocrylene
Odor: characteristic
Use: An oil-soluble UVB filter used in association with UVA or additional UVB absorbers for the creation of effective sunscreen formulations.
Vigon International
Neo Heliopan 303 (Octocrylene)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
National Technical Information Service. Vol. OTS0556792

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic UV absorber
Recommendation for octocrylene usage levels up to:
 not for fragrance use.
 
Recommendation for octocrylene flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):6197-30-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :22571
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate
Chemidplus:0006197304
EPA/NOAA CAMEO:hazardous materials
 
References:
 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):22571
Pubchem (sid):134987637
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
KEGG (GenomeNet):D05227
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 u.v. absorbers
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 BLS 3039 ultraviolet absorber
2-cyano-3,3-diphenylacrylic acid 2-ethylhexyl ester
2-ethyl hexyl 2-cyano-3,3-diphenyl acrylate
2-ethylhexyl 2-cyano-3,3-diphenyl acrylate
2-ethylhexyl 2-cyano-3,3-diphenyl-2-acrylate
2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate
2-ethylhexyl 2-cyano-3,3-diphenylacrylate
2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate
2-ethylhexyl 2-cyano-3,3-diphenylpropenoate
2-ethylhexyl-2-cyano-3,3-diphenylacrylate
 galsorb octocrylene
 heliosun OCR
 heliosun OCR USP
 neo heliopan 303 (Symrise)
 neoheliopan 303 (Symrise)
 octocrilene
 octocrylene USP
2-propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester
 uvinul N 539 T
 

Articles:

PubMed:Occurrence of eight UV filters in beaches of Gran Canaria (Canary Islands). An approach to environmental risk assessment.
PubMed:UV filters bioaccumulation in fish from Iberian river basins.
PubMed:Trans-resveratrol and beta-carotene from sunscreens penetrate viable skin layers and reduce cutaneous penetration of UV-filters.
PubMed:Simultaneous Liquid Chromatographic Determination of 10 Ultra-Violet Filters in Sunscreens.
PubMed:Multi-target determination of organic ultraviolet absorbents in organism tissues by ultrasonic assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry.
PubMed:The sensitization potential of sunscreen after ablative fractional skin resurfacing using modified human repeated insult patch test.
PubMed:Combination of retinyl palmitate and UV-filters: phototoxic risk assessment based on photostability and in vitro and in vivo phototoxicity assays.
PubMed:Photostability of cosmetic UV filters on mammalian skin under UV exposure.
PubMed:Method validation using weighted linear regression models for quantification of UV filters in water samples.
PubMed:[Determination of five representative ultraviolet filters in water by gas chromatography-mass spectrometry].
PubMed:Sunscreens.
PubMed:Ultraviolet filter contact and photocontact allergy: consumer exposure and risk assessment for octocrylene from personal care products and sunscreens.
PubMed:Reactivity of cosmetic UV filters towards skin proteins: model studies with Boc-lysine, Boc-Gly-Phe-Gly-Lys-OH, BSA and gelatin.
PubMed:Coupled exposure to ingredients of cosmetic products: III. Ultraviolet filters.
PubMed:Simultaneous nitrification/denitrification and trace organic contaminant (TrOC) removal by an anoxic-aerobic membrane bioreactor (MBR).
PubMed:Sun protection in children: realities and challenges.
PubMed:Contact and photocontact allergy to octocrylene: a review.
PubMed:Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations.
PubMed:Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio).
PubMed:Triplet-triplet energy transfer from a UV-A absorber butylmethoxydibenzoylmethane to UV-B absorbers.
PubMed:Effects of four commonly used UV filters on the growth, cell viability and oxidative stress responses of the Tetrahymena thermophila.
PubMed:Bioconcentration of organic contaminants in Daphnia resting eggs.
PubMed:Presence of UV filters in surface water and the effects of phenylbenzimidazole sulfonic acid on rainbow trout (Oncorhynchus mykiss) following a chronic toxicity test.
PubMed:Rapid screening method to study the reactivity of UV filter substances towards skin proteins by high-performance thin-layer chromatography.
PubMed:Coencapsulation of butyl-methoxydibenzoylmethane and octocrylene into lipid nanocarriers: UV performance, photostability and in vitro release.
PubMed:First determination of UV filters in marine mammals. Octocrylene levels in Franciscana dolphins.
PubMed:Effects of in vivo exposure to UV filters (4-MBC, OMC, BP-3, 4-HB, OC, OD-PABA) on endocrine signaling genes in the insect Chironomus riparius.
PubMed:Multi-residue method for trace level determination of UV filters in fish based on pressurized liquid extraction and liquid chromatography-quadrupole-linear ion trap-mass spectrometry.
PubMed:Contact allergy to octocrylene in children: a report of 2 cases.
PubMed:Allergic contact dermatitis due to sensitisation to sunscreen in two infants.
PubMed:UV filters, ingredients with a recognized anti-inflammatory effect.
PubMed:Characterization and evaluation of poly(epsilon-caprolactone) nanoparticles containing 2-ethylhexyl-p-methoxycinnamate, octocrylene, and benzophenone-3 in anti-solar preparations.
PubMed:The evolution of sunscreen products in the United States--a 12-year cross sectional study.
PubMed:Organic UV filters in personal care products in Switzerland: a survey of occurrence and concentrations.
PubMed:UV filters, ethylhexyl methoxycinnamate, octocrylene and ethylhexyl dimethyl PABA from untreated wastewater in sediment from eastern Mediterranean river transition and coastal zones.
PubMed:Contact allergy to topical corticosteroids and sunscreens.
PubMed:Allergic contact dermatitis caused by octocrylene in a young child.
PubMed:Bioconcentration of two pharmaceuticals (benzodiazepines) and two personal care products (UV filters) in marine mussels (Mytilus galloprovincialis) under controlled laboratory conditions.
PubMed:An overview of UV-absorbing compounds (organic UV filters) in aquatic biota.
PubMed:Quantification of sunscreen ethylhexyl triazone in topical skin-care products by normal-phase TLC/densitometry.
PubMed:Simultaneous analysis and monitoring of 16 UV filters in cosmetics by high-performance liquid chromatography.
PubMed:Solid lipid nanoparticles: a possible vehicle for zinc oxide and octocrylene.
PubMed:[Solar protection products: efficacy and risks].
PubMed:Investigation of the sunscreen octocrylene's interaction with amino acid analogs in the presence of UV radiation.
PubMed:Organic UV filter concentrations in marine mussels from French coastal regions.
PubMed:Ecotoxicological effect characterisation of widely used organic UV filters.
PubMed:Evaluation of low-cost disposable polymeric materials for sorptive extraction of organic pollutants in water samples.
PubMed:A European multicentre photopatch test study.
PubMed:Development and application of a HPLC method for eight sunscreen agents in suncare products.
PubMed:Analysis of UV filters in tap water and other clean waters in Spain.
PubMed:Occurrence and removal of benzotriazoles and ultraviolet filters in a municipal wastewater treatment plant.
PubMed:Electroanalytical determination of the sunscreen agent octocrylene in cosmetic products.
PubMed:Non-fragrance allergens in specific cosmetic products.
PubMed:Fast liquid chromatography-diode array detection assisted by chemometrics for quantification of seven ultraviolet filters in effluent wastewater.
PubMed:Simultaneous determination of benzotriazoles and ultraviolet filters in ground water, effluent and biosolid samples using gas chromatography-tandem mass spectrometry.
PubMed:Occurrence of multiclass UV filters in treated sewage sludge from wastewater treatment plants.
PubMed:Clinical and experimental studies of octocrylene's allergenic potency.
PubMed:Fast pressurized liquid extraction with in-cell purification and analysis by liquid chromatography tandem mass spectrometry for the determination of UV filters and their degradation products in sediments.
PubMed:Removal of micropollutants from aerobically treated grey water via ozone and activated carbon.
PubMed:A validated HPLC method for the determination of octocrylene in solid lipid nanoparticle systems.
PubMed:Occurrence and profiles of organic sun-blocking agents in surface waters and sediments in Japanese rivers and lakes.
PubMed:Simultaneous determination of some ultraviolet-absorbing chemicals in sunscreen cosmetics using a high-performance liquid chromatography method.
PubMed:Sexual abuse and anti-wrinkle cream: evidence from octocrylene.
PubMed:Silicone discs as disposable enrichment probes for gas chromatography-mass spectrometry determination of UV filters in water samples.
PubMed:Synthesis of a molecularly imprinted polymer and its application for microextraction by packed sorbent for the determination of fluoroquinolone related compounds in water.
PubMed:Optimization of pressurized liquid extraction and purification conditions for gas chromatography-mass spectrometry determination of UV filters in sludge.
PubMed:Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics.
PubMed:A rapid High Performance Liquid Chromatographic (HPLC) method for the simultaneous determination of seven UV filters found in sunscreen and cosmetics.
PubMed:Octocrylene, an emerging photoallergen.
PubMed:Simultaneous determination of UV filters and polycyclic musks in aqueous samples by solid-phase microextraction and gas chromatography-mass spectrometry.
PubMed:Emergent and unusual allergens in cosmetics.
PubMed:Stir-bar-sorptive extraction and ultra-high-performance liquid chromatography-tandem mass spectrometry for simultaneous analysis of UV filters and antimicrobial agents in water samples.
PubMed:Validation of HPLC method for the simultaneous and quantitative determination of 12 UV-filters in cosmetics.
PubMed:Filter-filter interactions. Photostabilization, triplet quenching and reactivity with singlet oxygen.
PubMed:Determination of organic UV filters in water by stir bar sorptive extraction and direct analysis in real-time mass spectrometry.
PubMed:Physicochemical study on microencapsulation of hydroxypropyl-beta-cyclodextrin in dermal preparations.
PubMed:Two cases of photocontact allergy to the new sun filter octocrylene.
PubMed:Addressing technical challenges associated with the FDA's proposed rules for the UVA in vitro testing procedure.
PubMed:Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate.
PubMed:Ultra-high-performance liquid chromatography-tandem mass spectrometry for determining the presence of eleven personal care products in surface and wastewaters.
PubMed:Irradiation of skin and contrasting effects on absorption of hydrophilic and lipophilic compounds.
PubMed:Determination of personal care products in sewage sludge by pressurized liquid extraction and ultra high performance liquid chromatography-tandem mass spectrometry.
PubMed:Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.
PubMed:Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.
PubMed:Incorporation in lipid microparticles of the UVA filter, butyl methoxydibenzoylmethane combined with the UVB filter, octocrylene: effect on photostability.
PubMed:A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions.
PubMed:Allergic and photoallergic contact dermatitis from ketoprofen: evaluation of cross-reactivities by a combination of photopatch testing and computerized conformational analysis.
PubMed:In vitro assessments of UVA protection by popular sunscreens available in the United States.
PubMed:Development of a human in vivo method to study the effect of ultraviolet radiation and sunscreens in melanocytic nevi.
PubMed:Multiclass determination of sunscreen chemicals in water samples by liquid chromatography-tandem mass spectrometry.
PubMed:Development of a method for the determination of UV filters in water samples using stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry.
PubMed:Study of the efficacy of 18 sun filters authorized in European Union tested in vitro.
PubMed:Photostability and efficacy studies of topical formulations containing UV-filters combination and vitamins A, C and E.
PubMed:Occurrence and behavior of four of the most used sunscreen UV filters in a wastewater reclamation plant.
PubMed:Determination of UV filters and antimicrobial agents in environmental water samples.
PubMed:A validated method for the determination of traces of UV filters in fish using LC-MS/MS.
PubMed:Sunscreen enhancement of UV-induced reactive oxygen species in the skin.
PubMed:Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment.
PubMed:Octocrylene: really non-allergenic?
PubMed:Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants.
PubMed:Evaluation of the photostability of different UV filter combinations in a sunscreen.
PubMed:Contact allergy to octocrylene in sunscreen with recurrence from passive transfer of a cosmetic.
PubMed:Sunscreens - which and what for?
PubMed:[Estrogenic activity of ultraviolet absorbers and the related compounds].
PubMed:Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland.
PubMed:Assay of common sunscreen agents in suncare products by high-performance liquid chromatography on a cyanopropyl-bonded silica column.
PubMed:Sunscreen penetration of human skin and related keratinocyte toxicity after topical application.
PubMed:Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss Lakes.
PubMed:Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.
PubMed:Effects of active sunscreen ingredient combinations on the topical penetration of the herbicide 2,4-dichlorophenoxyacetic acid.
PubMed:Development and validation of a non-aqueous reversed-phase high-performance liquid chromatographic method for the determination of four chemical UV filters in suncare formulations.
PubMed:Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes.
PubMed:Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid.
PubMed:Contact allergy to octocrylene.
PubMed:Evaluation of the capacity of sunscreens to photoprotect lupus erythematosus patients by employing the photoprovocation test.
PubMed:The stripping technique: in vitro absorption and penetration of five UV filters on excised fresh human skin.
PubMed:A full-UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging.
PubMed:Quantitative HPLC analysis of sunscreens and caffeine during in vitro percutaneous penetration studies.
PubMed:Comparative efficacy of sunscreen reapplication regimens in children exposed to ambient sunlight.
PubMed:Evaluation of subchronic (13 week), reproductive, and in vitro genetic toxicity potential of 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (Octocrylene).
 
Notes:
None found
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