EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 131-55-5Picture of molecule3D/inchi
Other(deleted CASRN):53236-95-6
ECHA EINECS - REACH Pre-Reg:205-028-9
Nikkaji Web:J39.680J
Beilstein Number:1914746
XlogP3-AA:2.40 (est)
Molecular Weight:246.21870000
Formula:C13 H10 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 531.23 °C. @ 760.00 mm Hg (est)
Flash Point: 552.00 °F. TCC ( 289.10 °C. ) (est)
logP (o/w): 3.091 (est)
Soluble in:
 water, 398.5 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: fragrance
uv absorbers
BOC Sciences
For experimental / research use only.
2,2',4,4'-Tetrahydroxybenzophenone >95.0%(T)
Charkit Chemical
Santa Cruz Biotechnology
For experimental / research use only.
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,2',4,4'-Tetrahydroxybenzophenone 97%
Sinoway Industrial
For experimental / research use only.
2,2',4,4'-Tetrahydroxy Benzophenone
For experimental / research use only.
2,2',4,4'-Tetrahydroxybenzophenone >98.0%(HPLC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1220 mg/kg
Journal of the American College of Toxicology. Vol. 2(5), Pg. 35, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic UV absorber
Recommendation for benzophenone-2 usage levels up to:
 not for fragrance use.
Recommendation for benzophenone-2 flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):131-55-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8571
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:DJ1892000 for cas# 131-55-5
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:131-55-5
Pubchem (cid):8571
Pubchem (sid):134973725
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.50.3000
Potential Blenders and core components note
None Found
Potential Uses:
 u.v. absorbers
Occurrence (nature, food, other):note
 not found in nature
 benzophenone, 2,2',4,4'-tetrahydroxy-
 methanone, bis(2,4-dihydroxyphenyl)-


PubMed:Cell-specific biotransformation of benzophenone-2 and bisphenol-s in zebrafish and human in vitro models used for toxicity and estrogenicity screening.
PubMed:A simple spectrophotometric method for the determination of arsenic in industrial and environmental samples using 2,4-Dihydroxy benzophenone-2-amino thiophenol.
PubMed:Toxicological effects of the sunscreen UV filter, benzophenone-2, on planulae and in vitro cells of the coral, Stylophora pistillata.
PubMed:Molecular structure, vibrational spectroscopic (FT-IR, FT-Raman), UV-vis spectra, first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis, thermodynamic properties of benzophenone 2,4-dicarboxylic acid by ab initio HF and density functional method.
PubMed:In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism.
PubMed:Synthesis, characterization, thermal and DNA-binding properties of new zinc complexes with 2-hydroxyphenones.
PubMed:Effects of the UV filter benzophenone-2 on reproduction in fish.
PubMed:In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes.
PubMed:Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats.
PubMed:Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone.
PubMed:BK/TD models for analyzing in vitro impedance data on cytotoxicity.
PubMed:Determining ultraviolet absorbents in sunscreen products by combining direct injection with micelle collapse on-line preconcentration capillary electrophoresis.
PubMed:A novel dispersive solid-phase extraction method using metal-organic framework MIL-101 as the adsorbent for the analysis of benzophenones in toner.
PubMed:A multiclass method for the analysis of endocrine disrupting chemicals in human urine samples. Sample treatment by dispersive liquid-liquid microextraction.
PubMed:Simplified matrix solid phase dispersion procedure for the determination of parabens and benzophenone-ultraviolet filters in human placental tissue samples.
PubMed:UHPLC-MS/MS method for the determination of bisphenol A and its chlorinated derivatives, bisphenol S, parabens, and benzophenones in human urine samples.
PubMed:A new method for the determination of benzophenone-UV filters in human serum samples by dispersive liquid-liquid microextraction with liquid chromatography-tandem mass spectrometry.
PubMed:Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (E2) in ovariectomized (ovx) rats.
PubMed:Contact allergy to benzophenone-2 in toilet water.
PubMed:Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl).
PubMed:A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats.
PubMed:The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase.
PubMed:Pharmacokinetics and metabolism of benzophenone 2 in the rat.
PubMed:Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment.
PubMed:Three novel lanthanide metal-organic frameworks (Ln-MOFs) constructed by unsymmetrical aromatic dicarboxylatic tectonics: synthesis, crystal structures and luminescent properties.
PubMed:Determination of trace levels of benzophenone-type ultra-violet filters in real matrices by bar adsorptive micro-extraction using selective sorbent phases.
PubMed:Doubly bonded E13═P and B═E15 molecules and their reactions with H2, acetonitrile, benzophenone, and 2,3-dimethylbutadiene.
PubMed:Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii.
PubMed:Structure elucidation and antioxidant activity of the phenolic compounds from Rhynchosia suaveolens.
PubMed:Identification of classifiers for increase or decrease of thyroid peroxidase activity in the FTC-238/hTPO recombinant cell line.
PubMed:Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis.
PubMed:[Determination of ultraviolet filters in environmental aqueous samples by dispersive liquid-liquid microextraction with online derivatization-gas chromatography-mass spectrometry].
PubMed:Determination of benzophenones in human placental tissue samples by liquid chromatography-tandem mass spectrometry.
PubMed:Development of a thyroperoxidase inhibition assay for high-throughput screening.
PubMed:Up-and-down shaker-assisted ionic liquid-based dispersive liquid-liquid microextraction of benzophenone-type ultraviolet filters.
PubMed:True photoallergy to sunscreens is rare despite popular belief.
PubMed:One new diphenylmethane glycoside from the leaves of Psidium guajava L.
PubMed:Determination of ultraviolet filters in water samples by vortex-assisted dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry.
PubMed:Characterisation and quantification of flavonoids in Iris germanica L. and Iris pallida Lam. resinoids from Morocco.
PubMed:Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation.
PubMed:Electrochemical oxidation of amides of type Ph2CHCONHAr.
PubMed:Pentacobalt(II) cluster based pcu network exhibits both magnetic slow-relaxation and hysteresis behaviour.
PubMed:Photochemistry of 2-diphenylmethoxyacetophenone. Direct detection of a long-lived enol from a Norrish Type II photoreaction.
PubMed:Hydrazone-based ligands for micro-solid phase extraction-high performance liquid chromatographic determination of biogenic amines in orange juice.
PubMed:Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) - an analysis with nonlinear isobolograms.
PubMed:Two new benzophenone glycosides from the fruit of Psidium guajava L.
PubMed:Comparison of in vitro and in vivo estrogenic activity of UV filters in fish.
PubMed:Principles and methodology for identification of fragrance allergens in consumer products.
PubMed:[Nail polish allergy. An important differential diagnosis in contact dermatitis].
PubMed:Simultaneous trace determination of nine organic UV-absorbing compounds (UV filters) in environmental samples.
PubMed:Ferrimagnetic [CoII3(micro3-OH)2(RCO2)4] chains embedded in a laminar hybrid material exhibiting single-chain magnet behaviour.
PubMed:Determination of ink photoinitiators in packaged beverages by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry.
PubMed:New phenolic principles from Hypericum sampsonii.
PubMed:Microbial removal of wastewater organic compounds as a function of input concentration in soil columns.
PubMed:Planar trimethylenemethane dianion chemistry of lanthanide metallocenes: synthesis, structure, density functional theory analysis, and reactivity of [(C5Me5)2Ln]2[mu-eta3:eta3-C(CH2)(3] Complexes.
PubMed:Activity related to the carcinogenicity of plastic additives in the benzophenone group.
PubMed:Site selectively templated and tagged xerogels for chemical sensors.
PubMed:Radical-induced generation of small silver particles in SPEEK/PVA polymer films and solutions: UV-Vis, EPR, and FT-IR studies.
PubMed:[Estrogenic activity of ultraviolet absorbers and the related compounds].
PubMed:Structure-reactivity relationships in the photoreduction of n,pi*-excited ketones and azoalkanes: the effect of reaction thermodynamics, excited-state electrophilicity, and antibonding character in the transition state.
PubMed:Experimental study on phototoxicity and the photosensitization potential of ketoprofen, suprofen, tiaprofenic acid and benzophenone and the photocross-reactivity in guinea pigs.
PubMed:Benzophenones of Garcinia pseudoguttifera (Clusiaceae).
None found
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