EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

butyl methoxydibenzoyl methane
1,3-propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-

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CAS Number: 70356-09-1Picture of molecule3D/inchi
Other(deleted CASRN):112725-59-4
ECHA EINECS - REACH Pre-Reg:274-581-6
Nikkaji Web:J149.841J
XlogP3-AA:4.80 (est)
Molecular Weight:310.39294000
Formula:C20 H22 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic UV absorber, UV filters
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Food Chemicals Codex Listed: No
Melting Point: 83.50 °C. @ 760.00 mm Hg
Boiling Point: 463.00 to 464.00 °C. @ 760.00 mm Hg (est)
Flash Point: 398.00 °F. TCC ( 203.10 °C. ) (est)
logP (o/w): 4.191 (est)
Soluble in:
 water, 1.517 mg/L @ 25 °C (est)
Insoluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
uv filters
American International Chemical, LLC.
Avobenzone USP
BOC Sciences
For experimental / research use only.
Avobenzone >98%
Odor: characteristic
Use: Avobenzone is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative.
ECSA Chemicals
Jiangyin Healthway
Butyl Methoxy Dibenzoyl Methane (Avobenzone)
New functional food ingredients
O'Laughlin Industries
O'Laughlin Industries
Penta International
For experimental / research use only.
Avobenzone analytical standard
Neo Heliopan® 357
Life Essentials - UV Protection
Odor: characteristic
Use: Neo Heliopan® 357 is a very effective oil-soluble UVA I absorber for a wide range of applications. Maximum absorption is at 357nm with a specific extinction of about 1100 and it has additional absorbing properties in the UVA II spectrum.
TRI-K Industries
GalSorb Avobenzone
Odor: characteristic
Use: An oil-soluble UVA absorber. In combination with UVB absorbers, it offers broad spectrum protection again UV radiation.
Vigon International
Neo Heliopan 357 (Butyl Methoxydibenzoyl-methane, Avobenzone)
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic UV absorber, UV filters
Recommendation for butyl methoxydibenzoyl methane usage levels up to:
 not for fragrance use.
Recommendation for butyl methoxydibenzoyl methane flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):70356-09-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :51040
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:70356-09-1
Pubchem (cid):51040
Pubchem (sid):135009607
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D03015
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
 u.v. absorbers
Occurrence (nature, food, other):note
 not found in nature
 butyl methoxydibenzoylmethane
1-(4-(1,1-dimethyl ethyl)phenyl)-3-(4-methoxyphenyl) propane-1,3-dione
 neo heliopan 357 (Symrise)
1,3-propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-
1,3-propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-


PubMed:Photostability of Cosmetic UV Filters on Mammalian Skin Under UV Exposure.
PubMed:Photodegradation of avobenzone: Stabilization effect of antioxidants.
PubMed:Coexistence effect of UVA absorbers to increase their solubility and stability of supersaturation.
PubMed:The risk of hydroquinone and sunscreen over-absorption via photodamaged skin is not greater in senescent skin as compared to young skin: nude mouse as an animal model.
PubMed:Coupled exposure to ingredients of cosmetic products: III. Ultraviolet filters.
PubMed:Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer.
PubMed:Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations.
PubMed:Seasonal occurrence, removal efficiencies and preliminary risk assessment of multiple classes of organic UV filters in wastewater treatment plants.
PubMed:Effects of the novel poly(methyl methacrylate) (PMMA)-encapsulated organic ultraviolet (UV) filters on the UV absorbance and in vitro sun protection factor (SPF).
PubMed:Relevance of UV filter/sunscreen product photostability to human safety.
PubMed:Photoprotection: part II. Sunscreen: development, efficacy, and controversies.
PubMed:Evaluation of nanostructured lipid carriers (NLC) and nanoemulsions as carriers for UV-filters: characterization, in vitro penetration and photostability studies.
PubMed:Drug-excipient compatibility studies in binary mixtures of avobenzone.
PubMed:The effect of Beta-cyclodextrin on percutaneous absorption of commonly used Eusolex® sunscreens.
PubMed:Influence of lipid microparticle encapsulation on in vitro efficacy, photostability and water resistance of the sunscreen agents, octyl methoxycinnamate and butyl methoxydibenzoylmethane.
PubMed:Coencapsulation of butyl-methoxydibenzoylmethane and octocrylene into lipid nanocarriers: UV performance, photostability and in vitro release.
PubMed:Butyl methoxy dibenzoylmethane.
PubMed:Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin.
PubMed:Evaluation of sunscreen safety by in vitro skin permeation studies: effects of vehicle composition.
PubMed:Lichenic extracts and metabolites as UV filters.
PubMed:Photothermal tautomerization of a UV sunscreen (4-tert-butyl-4'-methoxydibenzoylmethane) in acetonitrile studied by steady-state and laser flash photolysis.
PubMed:The evolution of sunscreen products in the United States--a 12-year cross sectional study.
PubMed:Organic UV filters in personal care products in Switzerland: a survey of occurrence and concentrations.
PubMed:Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate.
PubMed:Lipid nanoparticles based on butyl-methoxydibenzoylmethane: in vitro UVA blocking effect.
PubMed:Addition of UVA-absorber butyl methoxy dibenzoylmethane to topical ketoprofen formulation reduces ketoprofen-photoallergic reaction.
PubMed:Quantification of sunscreen ethylhexyl triazone in topical skin-care products by normal-phase TLC/densitometry.
PubMed:Simultaneous analysis and monitoring of 16 UV filters in cosmetics by high-performance liquid chromatography.
PubMed:Ecotoxicological effect characterisation of widely used organic UV filters.
PubMed:A European multicentre photopatch test study.
PubMed:Development and application of a HPLC method for eight sunscreen agents in suncare products.
PubMed:Polyamide nanocapsules and nano-emulsions containing Parsol® MCX and Parsol® 1789: in vitro release, ex vivo skin penetration and photo-stability studies.
PubMed:Photodegradation of (-)-epigallocatechin-3-gallate in topical cream formulations and its photostabilization.
PubMed:Synthesis and evaluation of novel tetrapropoxycalix[4]arene enones and cinnamates for protection from ultraviolet radiation.
PubMed:Differential scanning calorimetry studies on sunscreen loaded solid lipid nanoparticles prepared by the phase inversion temperature method.
PubMed:Photochemical and photophysical properties of dibenzoylmethane derivatives within protein.
PubMed:Pathways of lateral spreading.
PubMed:UV protection afforded by gel-trapped TiO2 particles.
PubMed:A survey of the availability of sunscreen filters in the UK.
PubMed:Encapsulation of the UV filters ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles: effect on in vivo human skin permeation.
PubMed:Photoprotective efficacy and photostability of fifteen sunscreen products having the same label SPF subjected to natural sunlight.
PubMed:Microencapsulation of a cyclodextrin complex of the UV filter, butyl methoxydibenzoylmethane: in vivo skin penetration studies.
PubMed:A rapid High Performance Liquid Chromatographic (HPLC) method for the simultaneous determination of seven UV filters found in sunscreen and cosmetics.
PubMed:Characterization of the UVA protection provided by avobenzone, zinc oxide, and titanium dioxide in broad-spectrum sunscreen products.
PubMed:Formulation of sunscreens with enhancement sun protection factor response based on solid lipid nanoparticles.
PubMed:True photoallergy to sunscreens is rare despite popular belief.
PubMed:Validation of HPLC method for the simultaneous and quantitative determination of 12 UV-filters in cosmetics.
PubMed:Filter-filter interactions. Photostabilization, triplet quenching and reactivity with singlet oxygen.
PubMed:Ultraviolet filters.
PubMed:Mechanochromic luminescence quenching: force-enhanced singlet-to-triplet intersystem crossing for iodide-substituted difluoroboron-dibenzoylmethane-dodecane in the solid state.
PubMed:Polymorphism and reversible mechanochromic luminescence for solid-state difluoroboron avobenzone.
PubMed:Addressing technical challenges associated with the FDA's proposed rules for the UVA in vitro testing procedure.
PubMed:Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate.
PubMed:Comparative evaluation of different substrates for the in vitro determination of sunscreen photostability: spectrophotometric and HPLC analyses.
PubMed:Identification and determination butylmethoxydibenzoylmethane in the presence benzophenone-3 and ethylhexylmethoxycinnamate in suncare preparation.
PubMed:Chronic actinic dermatitis: clinical cases, diagnostic workup, and therapeutic management.
PubMed:Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.
PubMed:Incorporation in lipid microparticles of the UVA filter, butyl methoxydibenzoylmethane combined with the UVB filter, octocrylene: effect on photostability.
PubMed:A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions.
PubMed:Role of UV light in photodamage, skin aging, and skin cancer: importance of photoprotection.
PubMed:Evaluation of spray congealing as technique for the preparation of highly loaded solid lipid microparticles containing the sunscreen agent, avobenzone.
PubMed:Prevention of polymorphic light eruption with a sunscreen of very high protection level against UVB and UVA radiation under standardized photodiagnostic conditions.
PubMed:In vitro assessments of UVA protection by popular sunscreens available in the United States.
PubMed:Validation of HPLC method for quantitative determination of Tinosorb S and three other sunscreens in a high protection cosmetic product.
PubMed:Co-loading of a photostabilizer with the sunscreen agent, butyl methoxydibenzoylmethane in solid lipid microparticles.
PubMed:A blocked diketo form of avobenzone: photostability, photosensitizing properties and triplet quenching by a triazine-derived UVB-filter.
PubMed:Determination of butyl methoxydibenzoylmethane, benzophenone-3, octyl dimethyl PABA and octyl methoxycinnamate in lipsticks.
PubMed:Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation.
PubMed:Assessing retinol stability in a hydroquinone 4%/retinol 0.3% cream in the presence of antioxidants and sunscreen under simulated-use conditions: a pilot study.
PubMed:Degradation kinetics of butylmethoxydibenzoylmethane (avobenzone) in aqueous solution.
PubMed:Influence of hydroxypropyl-beta-cyclodextrin on transdermal penetration and photostability of avobenzone.
PubMed:In vivo and in vitro skin permeation of butyl methoxydibenzoylmethane from lipospheres.
PubMed:Transdermal penetration of UV filters.
PubMed:OTC product: Anthelios SX.
PubMed:Mexoryl: a review of an ultraviolet a filter.
PubMed:Photostability and efficacy studies of topical formulations containing UV-filters combination and vitamins A, C and E.
PubMed:A new sunscreen agent.
PubMed:I've heard there's a new sunscreen that's supposed to offer better skin protection. Can you tell me more?
PubMed:The FDA approves new over-the-counter sunscreen.
PubMed:Photostabilization of organic UV-absorbing and anti-oxidant cosmetic components in formulations containing micronized manganese-doped titanium oxide.
PubMed:Transient enol isomers of dibenzoylmethane and avobenzone as efficient hydrogen donors toward a nitroxide pre-fluorescent probe.
PubMed:Interactions between different solar UVB/UVA filters contained in commercial suncreams and consequent loss of UV protection.
PubMed:Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-beta-cyclodextrin.
PubMed:Sun protection strength of a hydroquinone 4%/retinol 0.3% preparation containing sunscreens.
PubMed:Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostability.
PubMed:Sunscreens with an absorption maximum of > or =360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts.
PubMed:Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulations.
PubMed:Evaluation of the photostability of different UV filter combinations in a sunscreen.
PubMed:Assay of common sunscreen agents in suncare products by high-performance liquid chromatography on a cyanopropyl-bonded silica column.
PubMed:Sunscreen penetration of human skin and related keratinocyte toxicity after topical application.
PubMed:Estimation of the relative stratum corneum amount removed by tape stripping.
PubMed:Effects of silicone emulsifiers on in vitro skin permeation of sunscreens from cosmetic emulsions.
PubMed:Unexpected photolysis of the sunscreen octinoxate in the presence of the sunscreen avobenzone.
PubMed:Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays.
PubMed:Influence of cyclodextrins on in vitro human skin absorption of the sunscreen, butyl-methoxydibenzoylmethane.
PubMed:Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes.
PubMed:Lateral spreading of topically applied UV filter substances investigated by tape stripping.
PubMed:Bioconvertible vitamin antioxidants improve sunscreen photoprotection against UV-induced reactive oxygen species.
PubMed:Quantification of the horny layer using tape stripping and microscopic techniques.
PubMed:Non-invasive in vivo determination of UVA efficacy of sunscreens using diffuse reflectance spectroscopy.
PubMed:Skin penetration and sun protection factor of five UV filters: effect of the vehicle.
PubMed:Influence of hydroxypropyl-beta-cyclodextrin on photo-induced free radical production by the sunscreen agent, butyl-methoxydibenzoylmethane.
PubMed:UV filters in sunscreen products--a survey.
PubMed:A new model using liposomes that allow to distinguish between absorption and oxidative properties of sunscreens.
PubMed:Photoallergic contact dermatitis is uncommon.
PubMed:Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter.
PubMed:Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography. Use of cyclodextrins as mobile phase modifier.
PubMed:In vitro and in vivo estrogenicity of UV screens.
PubMed:[Determination of sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography].
PubMed:UVA protection efficacy of sunscreens can be determined by the persistent pigment darkening (PPD) method. (Part 2).
PubMed:In vitro assessment of the broad-spectrum ultraviolet protection of sunscreen products.
PubMed:High-performance liquid chromatographic method for the comparison of the photostability of five sunscreen agents.
PubMed:Photoallergic contact dermatitis due to combined UVB (4-methylbenzylidene camphor/octyl methoxycinnamate) and UVA (benzophenone-3/butyl methoxydibenzoylmethane) absorber sensitization.
PubMed:A novel in vivo model for evaluating agents that protect against ultraviolet A-induced photoaging.
PubMed:7 years experience of photopatch testing with sunscreen allergens in Sweden.
PubMed:Sunscreens' photochemical behaviour: in vivo evaluation by the stripping method.
PubMed:Determination of the photoprotective efficacy of a topical sunscreen against UVB-induced DNA damage in human epidermis.
PubMed:Shade UVAGuard--a second broad-spectrum sunscreen.
PubMed:Sunscreen dermatitis: Part III--The benzophenones.
PubMed:Actinic reticuloid: action spectra and UVA protection factor sunscreens.
PubMed:Broad-spectrum photoprotection: the roles of tinted auto windows, sunscreens and browning agents in the diagnosis and treatment of photosensitivity.
PubMed:Topical photoprotection for hereditary polymorphic light eruption of American Indians.
PubMed:Safety and efficacy of a broad-spectrum sunscreen in patients with discoid or subacute cutaneous lupus erythematosus.
PubMed:Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis.
PubMed:New fabrics to offer increased protection from the sun.
PubMed:Photoplex--a broad spectrum sunscreen.
PubMed:Indoor and outdoor efficacy testing of a broad-spectrum sunscreen against ultraviolet A radiation in psoralen-sensitized subjects.
PubMed:Contact allergy to butyl methoxydibenzoylmethane.
PubMed:Efficacy of a sunscreen containing butyl methoxydibenzoylmethane against ultraviolet A radiation in photosensitized subjects.
causes allergic or photoallergic contact dermatitis.
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