EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

ammonium thioglycolate
thioglycollic acid, ammonium salt

Supplier Sponsors

CAS Number: 5421-46-5Picture of molecule3D/inchi
Other(deleted CASRN):34316-71-7
ECHA EINECS - REACH Pre-Reg:226-540-9
Molecular Weight:109.14819000
Formula:C2 H7 N O2 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:depilatory agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 225.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.031400 mmHg @ 25.00 °C. (est)
Flash Point: 212.00 °F. TCC ( 99.80 °C. ) (est)
logP (o/w): 0.089 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: depilatories
hair straightening agents
hair waving agents
reducing agents
BOC Sciences
For experimental / research use only.
Ammonium thioglycollate solution;Hair waving agent 95%
Ammonium Thioglycolate
Odor: characteristic
Use: Ammonium Thioglycolate is produced by BRUNO BOCK and EVANS CHEMETICS as a high purity solution to be used in cosmetic applications like hair perms and straighteners. Special low odor grades are also available.
Santa Cruz Biotechnology
For experimental / research use only.
Ammonium thioglycolate solution
Sigma-Aldrich: Aldrich
For experimental / research use only.
Ammonium thioglycolate solution ∼60% in H2O
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LD50 175 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 349, 1949.

intraperitoneal-mouse LD50 100 mg/kg
National Technical Information Service. Vol. AD277-689

intravenous-rabbit LD50 100 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 349, 1949.

intraperitoneal-rat LD50 165 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 349, 1949.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
depilatory agents
Recommendation for ammonium thioglycolate usage levels up to:
 not for fragrance use.
Recommendation for ammonium thioglycolate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):5421-46-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :21534
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:5421-46-5
Pubchem (cid):21534
Pubchem (sid):134984848
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
•product formulation data (1989): hair straighteners- 1 formulation containing >25-50% ammonium thioglycolate; and 4 formulations containing >5-10%. permanent waves- 8 formulations containing >25-50% ammonium thioglycolate; 55 formulations containing >10-25%; 65 formulations containing >5-10%; 39 formulations containing >1-5%; and 8 formulations containing >0.1-1%. from table •commercial ammonium thioglycolate consists of ammonium thioglycolate (60%) and dithiodiglycolate (2% max). the following are listed in the cosmetic, toiletry, and fragrance association specification for ammonium thioglycolate: thioglycolic acid (between 50% and 60%), sulfated ash (0.05% max), arsenic (3ppm max), copper (1 ppm max), iron (1ppm max), and lead (20 ppm max).
Potential Blenders and core components note
None Found
Potential Uses:
 depilating agents
 reducing agents
Occurrence (nature, food, other):note
 natural product
 acetic acid, 2-mercapto-, ammonium salt
 acetic acid, mercapto-, monoammonium salt
 ammonium mercaptoacetate
 ammonium sulfanylacetate
 ammonium thioglycollate
 mercaptoacetic acid, monoammonium salt
 thiofaco A-50
 thioglycolic acid ammonium salt
 thioglycollic acid, ammonium salt


PubMed:Biosorption of multifold toxic heavy metal ions from aqueous water onto food residue eggshell membrane functionalized with ammonium thioglycolate.
PubMed:Protein loss in human hair from combination straightening and coloring treatments.
PubMed:Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid.
PubMed:Allergic contact dermatitis to ammonium thioglycolate.
PubMed:Lack of systemic effect of topically applied ammonium thioglycolate and paraphenylenediamine in guinea pigs.
PubMed:[Prevention of ammonium thioglycolate injuries in cold waves].
PubMed:[Dermatitis caused by ammonium thioglycolate; genesis and prevention of pathology in cold wave permanent waving].
PubMed:The effect of home permanent wave preparations (ammonium thioglycolate and potassium bromate) on hair.
PubMed:Permanent wave process; clinical report with special reference to the effect of ammonium thioglycolate on the skin.
PubMed:Coloring, bleaching, and perming: influence on EtG content in hair.
PubMed:Prick testing with chemicals in the diagnosis of occupational contact urticaria and respiratory diseases.
PubMed:Study of the frequency of allergens in cosmetics components in patients with suspected allergic contact dermatitis.
PubMed:Baseline sebum IL-1α is higher than expected in afro-textured hair: a risk factor for hair loss?
PubMed:Measurement of concentrations of thioglycolic acid, dithiodiglycolic acid and ammonia in indoor air of a beauty salon.
PubMed:Prospective ultramorphological characterization of human hair by optical coherence tomography.
PubMed:Water soluble complexes of C14 and C16 fatty acids and alcohols in media for cultivation of leprosy-derived psychrophilic mycobacteria.
PubMed:Protective effect of conditioning agents on Afro-ethnic hair chemically treated with thioglycolate-based straightening emulsion.
PubMed:[Results of patch test in hairdressers examined in the institute of occupational medicine in Łódź].
PubMed:Contact dermatitis in hairdressers, 10 years later: patch-test results in 300 hairdressers (1994 to 2003) and comparison with previous study.
PubMed:Nasal provocation test in the diagnostics of hairdressers' occupational rhinitis.
PubMed:Water soluble complex of palmitic acid in media for cultivation of leprosy-derived psychrophilic mycobacteria from Mycobacterium leprae infected tissues.
PubMed:[Glycerol monothioglycolate eczema in a hairdresser. Persistence of the allergen in the hair several weeks after the application of a permanent].
PubMed:Semiautomated monolayer preparation of bronchial secretions using AutoCyte PREP.
PubMed:Toxic mechanism of bromate poisoning in a dog: a case study.
PubMed:Occupational allergic contact dermatitis in beauticians.
PubMed:Determination of dye intermediates in oxidative hair dyes by fused-silica capillary gas chromatography.
PubMed:Permanent wave contact dermatitis: contact allergy to glyceryl monothioglycolate.
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy