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disodium phosphate
sodium monohydrogen phosphate (2:1:1)

Sponsors

CAS Number: 7558-79-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:231-448-7
FDA UNII:22ADO53M6F
MDL:MFCD00003496
Molecular Weight:141.95807056
Formula:H Na2 O4 P
NMR Predictor:Predict (works with chrome or firefox)
Category:multiple purpose GRAS food substances, acidity regulators
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
1975 Sodium phosphate dibasic View-review
EU SANCO Sodium phosphates View-review
JECFA Food Additive: Disodium Hydrogen Phosphate
GSFA Codex: Disodium hydrogen phosphate (339(ii))
FEMA Number:2398 disodium phosphate
FDA Mainterm: SODIUM PHOSPHATE, DIBASIC
FDA Regulation:
FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.169 Pasteurized process cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.173 Pasteurized process cheese food.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.179 Pasteurized process cheese spread.


FDA PART 135 -- FROZEN DESSERTS
Subpart B--Requirements for Specific Standardized Frozen Desserts
Sec. 135.110 Ice cream and frozen custard.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.305 Enriched farina.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.110 Macaroni products.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.210 Acrylate ester copolymer coating.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.29 Stabilizers.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart B--Multiple Purpose GRAS Food Substances
Sec. 182.1778 Sodium phosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart G--Sequestrants1
Sec. 182.6290 Disodium phosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart G--Sequestrants1
Sec. 182.6778 Sodium phosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart I--Nutrients
Sec. 182.8778 Sodium phosphate.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.85 Caramel.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 240.00 °C. @ 760.00 mm Hg
Boiling Point: 158.00 °C. @ 760.00 mm Hg (est)
PH Number:8.90
Vapor Pressure:1.410000 mm/Hg @ 25.00 °C. (est)
Vapor Density:4.9 ( Air = 1 )
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -2.148 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light. store under nitrogen.
Storage:store under nitrogen.
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 
Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. odorless
Luebke, William tgsc, (2007)
Odor sample from: Sigma-Aldrich
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: anticorrosive agents
buffering agents
masking agents
 
Suppliers:
Allan Chemical
Sodium Phosphate Dibasic
American Elements
Sodium Phosphate Dibasic 99%
Odor: characteristic
Use: Sodium Phosphate Dibasic is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
DISODIUM PHOSPHATE ANHYDROUS FCC GRANULAR
BOC Sciences
For experimental / research use only.
Disodium hydrogenorthophosphate dibasic, 98%
Dow Chemical
Sodium Phos Dibasic Anhydrous ACS/USP
ECSA Chemicals
Disodium Phosphate
Company Profile
Foodchem International
Disodium Phosphate
Graham Chemical
Disodium Phosphate
Jost Chemical
Sodium Phosphate Dibasic Anhydrous ACS Granular
Jost Chemical
Sodium Phosphate Dibasic Anhydrous USP Granular
Kraft Chemical
Disodium Phosphate
Penta International
SODIUM PHOSPHATE DIBASIC ANHYDROUS POWDER FCC, Kosher
Penta International
SODIUM PHOSPHATE DIBASIC DRIED POWDER USP/NF, Kosher
Prinova
Disodium Phosphate Anhydrous
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Phosphate, Dibasic ≥99%
Sigma-Aldrich
Sodium phosphate dibasic, 99%, FG
Certified Food Grade Products
Zhong Ya Chemical
Sodium Phosphate, Di
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 17000 mg/kg
Sigma-Aldrich

intravenous-rabbit LDLo 1075 mg/kg
BEHAVIORAL: TETANY
Handbuch der Experimentellen Pharmakologie. Vol. 10, Pg. 361, 1950.

oral-rat LD50 17000 mg/kg
"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 16, 1972.

intramuscular-rat LDLo 1000 mg/kg
Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925.

intraperitoneal-rat LDLo 1000 mg/kg
Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925.

Dermal Toxicity:
subcutaneous-rat LDLo 1000 mg/kg
Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: multiple purpose GRAS food substances, acidity regulators
Recommendation for disodium phosphate usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -2300.00000
beverages(nonalcoholic): -350.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -350.00000
fruit ices: -350.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 50.00000250.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials
View page or View pdf
Assessment of one published review on health risks associated with phosphate additives in food
View page or View pdf
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):7558-79-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24203
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3077
WGK Germany:1
disodium hydrogen phosphate
Chemidplus:0007558794
EPA/NOAA CAMEO:hazardous materials
RTECS:7558-79-4
 
References:
 disodium hydrogen phosphate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7558-79-4
Pubchem (cid):24203
Pubchem (sid):134986680
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C13558
HMDB (The Human Metabolome Database):Search
FooDB:FDB013359
Export Tariff Code:2835.22.0000
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•sodium phosphates injection, usp, 3 mm pml (millimolesml)each ml contains 276 mg of monobasic sodium phosphate, monohydrate and 142 mg of dibasic sodium phosphate, anhydrous (equivalent to 268 mg of dibasic sodium phosphate, heptahydrate). it contains no bacteriostat, antimicrobial agent or added buffer. •sodium phosphate preparations: (ahfs, 2009) sodium phosphate preparations: (ahfs, 2009) route dosage form strength brand or generic name (manufacturer) tablet dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g osmoprep (salix) tablet dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g visicol (salix) rectal solution dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml fleet enema (fleet) rectal solution dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml fleet pediatric enema (fleet) •visicol (sodium phosphate monobasic monohydrate, usp, and sodium phosphate dibasic anhydrous, usp)each tablet contains 1.102 grams of sodium phosphate monobasic monohydrate, usp and 0.398 grams of sodium phosphate dibasic anhydrous, usp for a total of 1.5 grams of sodium phosphate per tablet. inert ingredients include microcrystalline cellulose (mcc), nf; magnesium stearate, nf; and colloidal silicon dioxide, nf. visicol is gluten-free. •sodium phosphate and sodium biphosphate enema usp dosage forms-- enema usp: 6% sodium phosphate and 16% sodium biphosphate; sodium phosphate and sodium biphosphate oral solution usp dosage forms-- solution usp: 18% sodium phosphate and 48% sodium biphosphate. •sorensen's phosphate, sorensen's sodium phosphate. disodium phosphate dihydrate •fleet's enema: solution (sodium phosphate 6 g and sodium biphosphate 16 g). fleet's phospho-soda: (sodium phosphate 18 g and sodium biphosphate 48 g). •an oral soln (fleet phospho-soda) contains 1.8 g of dibasic sodium phosphate and 4.8 g of monobasic sodium phosphate in 10 ml saline laxatives •grade: commercial, nf national formulary grade of chemical (sodium phosphate, dibasic anhydrous and heptahydrate), fcc food chemicals codex (sodium phosphate, dibasic anhydrous or dihydrate) •available as anhydrous or dihydric salts.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 anticorrosive agents
 buffering agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 disodium hydrogen phosphate
 disodium phosphate (food grade)
 disodium phosphate anhydrous
 disodium phosphate anhydrous FCC granular
 phosphoric acid disodium salt
 sodium monohydrogen phosphate (2:1:1)
 sodium phosphate (NaHPO4)
 sodium phosphate dibasic
 sodium phosphate dibasic anhydrous ACS
 sodium phosphate dibasic anhydrous powder FCC
 sodium phosphate dibasic anhydrous ultra pure
 sodium phosphate dibasic anhydrous USP
 sodium phosphate dibasic dried powder USP/NF
 sodium phosphate, di
 
 
Notes:
Used in foods as a sequestrant, emulsifier, buffering agent, absorbent, pH control agent, protein modifier, source of alkalinity, stabiliser and nutrient supplement Disodium hydrogen phosphate (Na2HPO4) is a sodium salt of phosphoric acid. It is a white powder that is highly hygroscopic and water soluble. It is therefore used commercially as an anti-caking additive in powdered products. It is also known as disodium hydrogen orthophosphate, sodium hydrogen phosphate or sodium phosphate dibasic. It is commercially available in both the hydrated and anhydrous forms.
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