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sodium metabisulfite
disodium disulfite

Supplier Sponsors

Name:disodium oxidosulfanesulfonate oxide
CAS Number: 7681-57-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:231-673-0
Nikkaji Web:J44.049C
Molecular Weight:190.10553856
Formula:Na2 O5 S2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antibrowning agents, antioxidants, flour treatment agents, preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
182.3766 Sodium metabisulfite View - review
EU SANCO Sodium metabisulphite View - review
JECFA Food Additive: Sodium Metabisulfite
GSFA Codex: Sodium metabisulfite (223)
DG SANTE Food Additives:sodium metabisulphite
FDA Regulation:
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.

Subpart D--Chemical Preservatives
Sec. 182.3766 Sodium metabisulfite.
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 90.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, slightly
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
reducing agents
American Elements
Sodium Metabisulfite 99%
Odor: characteristic
Use: Sodium Metabisulfite is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
BOC Sciences
For experimental / research use only.
Sodium Metabisulfite, granular 95%
Charkit Chemical
Covalent Chemical
Sodium Metabisulfite
ECSA Chemicals
ECSA Chemicals
Foodchem International
Sodium Metabisulfite
Glentham Life Sciences
Sodium metabisulfite
Indis NV
For experimental / research use only.
Sodium Metabisulfite
Kraft Chemical
Sodium Metabisulfite
Krunal Group
Sodium Metabisulphite
Penta International
Penta International
Penta International
For experimental / research use only.
Sodium Metabisulfite puriss. p.a., ACS reagent, reag. Ph. Eur., dry, 98-100.5%
Tianjin Talent Chemical
Sodium Metabisulfite
Wedor Corporation
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1131 mg/kg
National Technical Information Service. Vol. OTS0556695

intravenous-rat LD50 115 mg/kg
Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 1418, 1991.

parenteral-mouse LD50 910 mg/kg
Russian Pharmacology and Toxicology Vol. 31, Pg. 120, 1968.

intravenous-rabbit LDLo 192 mg/kg
Toxicology and Applied Pharmacology. Vol. 24, Pg. 266, 1973.

intravenous-rat LD50 115 mg/kg
"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 1418, 1991.

Dermal Toxicity:
skin-rat LD50 > 2000 mg/kg
National Technical Information Service. Vol. OTS0557608

skin-guinea pig LD50 > 1000 mg/kg
National Technical Information Service. Vol. OTS0556695

Inhalation Toxicity:
Not determined
Safety in Use Information:
antibrowning agents, antioxidants, flour treatment agents, preservatives
Recommendation for sodium metabisulfite usage levels up to:
 not for fragrance use.
Recommendation for sodium metabisulfite flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228) as food additives
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):7681-57-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :656671
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
disodium oxidosulfanesulfonate oxide
EPA/NOAA CAMEO:hazardous materials
 disodium oxidosulfanesulfonate oxide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7681-57-4
Pubchem (cid):656671
Pubchem (sid):134988696
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):D02054
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
•grades: fcc •the commercial product has a content of about 97% na2s2o5, 1-2% na2so3, and about 1% na2so4. •available in photographic, food and nf national formulary grades •it may be considered to be the anhydride of sodium bisulfite, and is reportedly the chief constituent of the commercial grade of the latter compound. •anhydrous acs, fcc, photo, usp, food, and technical grades; 38% solution: technical grade •uvas quality grape guard (imal ltda.) disulfurous acid, disodium salt 98% •osku-vid dual release grape guard (productos quimicos y alimenticios osku s.a.) disulfurous acid, disodium salt 98% •osku-vid single release grape guard (productos quimicos y alimenticios osku s.a.) disulfurous acid, disodium salt 98% •osku-hellas grape guard (productos quimicos y alimenticios osku s.a.) disulfurous acid, disodium salt 73.5% •preserva uvas dos fases (quimetal industrial s.a.) disulfurous acid, disodium salt 98.2% •uvasys (grapetek (pty) ltd.) disulfurous acid, disodium salt 37.55% •proem dual release grape guard (embalajes proem ltda.) disulfurous acid, disodium salt 98% •proem slow release grape guard (embalajes proem ltda.) disulfurous acid, disodium salt 98% •proteku grape guard (insumos fruticolas s.a infruta) disulfurous acid, disodium salt 98.5% •matesa grape guard (materiales de embalaje s.a.) disulfurous acid, disodium salt 98% •smartpac (quimas s.a.) disulfurous acid, disodium salt 8.66%
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 disodium disulfite
 disodium metabisulfite
 disodium oxidosulfanesulfonate oxide
 disodium pyrosulfite
 disodium sulfinatosulfonate
 disulfurous acid sodium salt (1:2)
 sodium metabisulfite granular
 sodium metabisulphite
 soldium metabisulfite crystals FCC grade
 sulfanesulfonate, 1-olato-, oxide, sodium salt (1:2)


PubMed:The molecular mechanisms of sodium metabisulfite on the expression of KATP and L-Ca(2+) channels in rat hearts.
PubMed:Occupational asthma in seafood manufacturing and food allergy to seafood.
PubMed:Induction of xanthine oxidase activity, endoplasmic reticulum stress and caspase activation by sodium metabisulfite in rat liver and their attenuation by Ghrelin.
PubMed:Effects of sodium metabisulfite on the expression of BK(Ca), K(ATP), and L-Ca(2+) channels in rat aortas in vivo and in vitro.
PubMed:Influence of productivity and processing method on physicochemical characteristics of white button mushrooms in Brazil.
PubMed:Purification and partial biochemical characterization of polyphenol oxidase from mango (Mangifera indica cv. Manila).
PubMed:Development of a selective agar plate for the detection of Campylobacter spp. in fresh produce.
PubMed:Post-harvest control of gray mold in table grapes using volatile sulfur compounds from Allium sativum.
PubMed:Characterization of a versatile arylesterase from Lactobacillus plantarum active on wine esters.
PubMed:Protective role of curcumin against sulfite-induced structural changes in rats' medial prefrontal cortex.
PubMed:Curcumin can prevent the changes in cerebellar structure and function induced by sodium metabisulfite in rat.
PubMed:Chemical treatments for reducing the yellow discoloration of channel catfish (Ictalurus punctatus) fillets.
PubMed:Characterization of three deoxynivalenol sulfonates formed by reaction of deoxynivalenol with sulfur reagents.
PubMed:Effects of a Fusarium toxin-contaminated maize treated with sodium metabisulphite, methylamine and calcium hydroxide in diets for female piglets.
PubMed:Storage stability of low-fat sodium reduced fresh merguez sausage prepared with olive oil in konjac gel matrix.
PubMed:Inactivation of deoxynivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects.
PubMed:Curcumin, the main part of turmeric, prevents learning and memory changes induced by sodium metabisulfite, a preservative agent, in rats.
PubMed:Hydrothermal treatment of naturally contaminated maize in the presence of sodium metabisulfite, methylamine and calcium hydroxide; effects on the concentration of zearalenone and deoxynivalenol.
PubMed:Pigment, physicochemical, and microbiological changes related to the freshness of cracked table olives.
PubMed:Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa.
PubMed:Merit of quinacrine in the decrease of ingested sulfite-induced toxic action in rat brain.
PubMed:Allergic contact dermatitis caused by sodium metabisulfite: a challenging allergen: a case series and literature review.
PubMed:The vasodilator mechanisms of sodium metabisulfite on precontracted isolated aortic rings in rats: signal transduction pathways and ion channels.
PubMed:Effect of inert atmosphere on the postharvest browning of manzanilla olives and optimization by response surface methodology of the aqueous treatments.
PubMed:Preservation of acidified cucumbers with a combination of fumaric acid and cinnamaldehyde that target lactic acid bacteria and yeasts.
PubMed:Effect of processing and packaging conditions on quality of refrigerated potato strips.
PubMed:Hippocampal neuron number loss in rats exposed to ingested sulfite.
PubMed:Effect of bruising on respiration, superficial color, and phenolic changes in fresh Manzanilla olives (Olea europaea pomiformis): development of treatments to mitigate browning.
PubMed:Genotoxicity of sodium metabisulfite in mouse tissues evaluated by the comet assay and the micronucleus test.
PubMed:Purification and partial biochemical characterization of polyphenol oxidase from mamey (Pouteria sapota).
PubMed:Dose-dependent effect of nutritional sulfite intake on visual evoked potentials and lipid peroxidation.
PubMed:Stability of apigeninidin and its methoxylated derivatives in the presence of sulfites.
PubMed:Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels.
PubMed:Investigations on the kinetics of the concentration of deoxynivalenol (DON) and on spoilage by moulds and yeasts of wheat grain preserved with sodium metabisulfite (Na2S2O5, SBS) and propionic acid at various moisture contents.
PubMed:Preservation of acidified cucumbers with a natural preservative combination of fumaric acid and allyl isothiocyanate that target lactic acid bacteria and yeasts.
PubMed:Sodium metabisulfite induces lipid peroxidation and apoptosis in rat gastric tissue.
PubMed:Studies on the toxicity of deoxynivalenol (DON), sodium metabisulfite, DON-sulfonate (DONS) and de-epoxy-DON for porcine peripheral blood mononuclear cells and the Intestinal Porcine Epithelial Cell lines IPEC-1 and IPEC-J2, and on effects of DON and DONS on piglets.
PubMed:Modelling the effect of ascorbic acid, sodium metabisulphite and sodium chloride on the kinetic responses of lactic acid bacteria and yeasts in table olive storage using a specifically implemented Quasi-chemical primary model.
PubMed:Sodium metabisulfite modulation of potassium channels in pain-sensing dorsal root ganglion neurons.
PubMed:Spinal reflexes in normal and sulfite oxidase deficient rats: effect of sulfite exposure.
PubMed:Sodium metabisulphite induced airways disease in the fishing and fish-processing industry.
PubMed:Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the 13C-methacetin breath test.
PubMed:Effect of sulfite treatment on total antioxidant capacity, total oxidant status, lipid hydroperoxide, and total free sulfydryl groups contents in normal and sulfite oxidase-deficient rat plasma.
PubMed:Chlorhexidine with an anti discoloration system after periodontal flap surgery: a cross-over, randomized, triple-blind clinical trial.
PubMed:Effect of preservative agents on the respiration rate of minimally processed potato (Solanum tuberosum cv. Monalisa).
PubMed:Determination of free and reversibly-bound sulfite in selected foods by high-performance liquid chromatography with fluorometric detection.
PubMed:Sodium metabisulfite allergy is common but is it relevant?
PubMed:Effect of storage process on the sugars, polyphenols, color and microbiological changes in cracked Manzanilla-AloreƱa table olives.
PubMed:Media for the aerobic resuscitation of Campylobacter jejuni.
PubMed:Pineapple juice and its fractions in enzymatic browning inhibition of banana [Musa (AAA group) Gros Michel].
PubMed:The effect of sulfite and chronic restraint stress on brain lipid peroxidation and anti-oxidant enzyme activities.
PubMed:Investigation of Australian olive mill waste for recovery of biophenols.
PubMed:Food additive-induced chronic pruritus: further evidence.
PubMed:The effects of various antifungal additives on the fermentation and aerobic stability of corn silage.
PubMed:The prooxidant effect of sodium metabisulfite in rat liver and kidney.
PubMed:The effect of chronic restraint stress and sulfite on visual evoked potentials (VEPs): relation to lipid peroxidation.
PubMed:Effect of sulfite on red blood cell deformability ex vivo and in normal and sulfite oxidase-deficient rats in vivo.
PubMed:Effect of sulfite on macrophage functions of normal and sulfite oxidase-deficient rats.
PubMed:Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere.
PubMed:Effect of preparation conditions on protein secondary structure and biofilm formation of kafirin.
PubMed:Effects of sodium metabisulfite on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus.
PubMed:Gas chromatographic evaluation of pesticide residue contents in nectarines after non-toxic washing treatments.
PubMed:Sulfur-containing arsenical mistaken for dimethylarsinous acid [DMA(III)] and identified as a natural metabolite in urine: major implications for studies on arsenic metabolism and toxicity.
PubMed:Effect of sodium metabisulphite on germination, growth and yield of Vigna sinensis, Savi.
PubMed:Inactivation of Salmonella during drying and storage of apple slices treated with acidic or sodium metabisulfite solutions.
PubMed:Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food additives in chronic urticaria patients.
PubMed:Effect of endogenous triacylglycerol hydrolysates on the mechanical properties of Zein films from ground corn.
PubMed:Mycotoxins inactivation by extrusion cooking of corn flour.
PubMed:Carotenoid content, physicochemical, and sensory qualities of deep-fried carrot chips as affected by dehydration/rehydration, antioxidant, and fermentation.
PubMed:Chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with sodium metabisulfite, a food preservative.
PubMed:Absence of adverse effects of sodium metabisulphite in manufactured biscuits: results of subacute (28-days) and subchronic (85-days) feeding studies in rats.
PubMed:Contact dermatitis from sodium metabisulfite in a baker.
PubMed:An effective lacticin biopreservative in fresh pork sausage.
PubMed:Propofol containing sulfite-potential for injury.
PubMed:[Effect of cooking on protein digestibility of sorghum (Sorghum bicolor (L.) Moench)].
PubMed:Use and removal of sulfite by conversion to sulfate in the preservation of salt-free cucumbers.
PubMed:Effect of sodium metabisulfite on hydrogen peroxide production in light-exposed pediatric parenteral amino acid solutions.
PubMed:4-Hexylresorcinol as inhibitor of shrimp melanosis: efficacy and residues studies; evaluation of possible toxic effect in a human intestinal in vitro model (Caco-2); preliminary safety assessment.
PubMed:Utilization of the skin attachment model to determine the antibacterial efficacy of potential carcass treatments.
PubMed:[Clinical signs of food allergy].
PubMed:[Chemical and biological evaluation of ripe banana peel].
PubMed:[Prevalence of chronic urticaria following the ingestion of food additives in a third tier hospital].
PubMed:Assessment of food chemical intolerance in adult asthmatic subjects.
PubMed:Pickled onion-induced asthma: a model of sulfite-sensitive asthma?
PubMed:Microbiological evaluation of dressing procedures for crocodile carcases in Queensland.
PubMed:The control of polyphenol oxidase activity in fruits and vegetables. A study of the interactions between the chemical compounds used and heat treatment.
PubMed:[Allergy and professional exposure to sulfur compounds: questions posed].
PubMed:[Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives].
PubMed:Comparison of sulphur dioxide and metabisulphite airway reactivity in subjects with asthma.
PubMed:Effect of sulfite intake on intestinal enzyme activity in rats.
PubMed:Sodium metabisulfite and SO2 release: an under-recognized hazard among shrimp fishermen.
PubMed:Evaluation of phototoxic properties of some food additives: sulfites exhibit prominent phototoxicity.
PubMed:Effect of sample pretreatments on the storability of ground melon 'egusi'-Colocynthis citrillus L.
PubMed:Disulfite-induced acute intermittent urticaria with vasculitis.
PubMed:Toxicology of sulphiting agents. I: Animal studies.
PubMed:Precipitation of asthma attacks in Melanesian adults by sodium metabisulphite.
PubMed:Mechanisms of metabisulfite-induced bronchoconstriction: evidence for bradykinin B2-receptor stimulation.
PubMed:Intolerance to sodium metabisulfite in children with steroid-dependent asthma.
PubMed:Effects of heating time and sodium metabisulfite on the nutritional value of full-fat soybeans for chicks.
PubMed:Processing and quality evaluation of sweet potato chips.
PubMed:Effects of sodium metabisulphite, hydrogen peroxide and heat on aflatoxin B1 in lafun and gari--two cassava products.
PubMed:Effect of inhaled preservatives on asthmatic subjects. I. Sodium metabisulfite.
PubMed:Viability of Salmonella in bone meal.
PubMed:Food and food additives in severe atopic dermatitis.
PubMed:[Asthma due to disulfites].
PubMed:Aspirin-like effects of selected food additives and industrial sensitizing agents.
PubMed:The structural identification of a secondary dye produced from the reaction between sunset yellow and sodium metabisulphite.
PubMed:A double-blind assessment of additive intolerance in children using a 12 day challenge period at home.
PubMed:[Frequency of urticaria and angioedema induced by food additives].
PubMed:Oral challenge test with sodium metabisulfite in steroid-dependent asthmatic patients.
PubMed:Peroral challenge tests with food additives in urticaria and atopic dermatitis.
PubMed:Allergic reaction to sulfiting agents.
PubMed:Provocative testing for sulfite sensitivity in clinical allergy.
PubMed:[Adverse reactions to food preservatives].
PubMed:Adverse reactions to sulfites.
PubMed:Ophthalmic medications that contain sulfites.
PubMed:Metabisulfite challenge in patients with idiopathic anaphylaxis.
PubMed:Selected enrichment broths for recovery of Campylobacter jejuni from foods.
PubMed:Role of acetyl salicylic acid and sodium metabisulfite in chronic childhood asthma.
PubMed:Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method.
PubMed:Anaphylaxis to a component of isoetharine (sodium bisulfite).
PubMed:Alcohol-induced bronchospasm.
PubMed:Bronchospasm induced by metabisulphite-containing foods and drugs.
PubMed:Antibotulinal efficacy of sulfur dioxide in meat.
PubMed:Viability of Salmonella typhimurium in metabisulphite-treated bone meal: effect of inocula and moisture variation on the lethal potency of metabisulphite.
PubMed:A comparative study of the lethal effect of metabisulphite on the viability of three bacterial species in bone meal and gelatin.
PubMed:Sodium metabisulfite as a preservative for silage produced from maize plants.
PubMed:[Toxicity of sodium metabisulfite for sheep].
PubMed:New quantitative, qualitative, and confirmatory media for rapid analysis of food for Clostridium perfringens.
PubMed:Status of iodine in milk preserved with sodium metabisulfite and formaldehyde.
request from searcher. Food preservative; sanitising agent for food containers and fermentation equipment Sodium metabisulfite or sodium pyrosulfite (IUPAC spelling; Br. E. sodium metabisulphite or sodium pyrosulphite) is an inorganic compound of chemical formula Na2S2O5. The substance is sometimes referred to as disodium (metabisulfite). It is used as a disinfectant, antioxidant and preservative agent. (Wikipedia)
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