EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

potassium metabisulfite
disulfurous acid, potassium salt (1:2)

Supplier Sponsors

CAS Number: 16731-55-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:240-795-3
Nikkaji Web:J43.952E
Molecular Weight:222.32260000
Formula:K2 O5 S2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antibrowning agents, antioxidants, preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
182.3637 Potassium metabisulfite View - review
EU SANCO Potassium metabisulphite View - review
JECFA Food Additive: Potassium Metabisulfite
GSFA Codex: Potassium metabisulfite (224)
DG SANTE Food Additives:potassium metabisulphite
FDA Regulation:
Subpart D--Chemical Preservatives
Sec. 182.3637 Potassium metabisulfite.
Physical Properties:
Appearance:colorless crystalline powder (est)
Assay: 90.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair fixing agents
hair waving agents
reducing agents
American Elements
Potassium Metabisulfite 99%
Odor: characteristic
Use: Potassium Metabisulfite is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
BOC Sciences
For experimental / research use only.
Potassium metabisulfite Purity >95%
Charkit Chemical
Glentham Life Sciences
Potassium metabisulfite, 98%
Glentham Life Sciences
Potassium metabisulfite
Indis NV
For experimental / research use only.
Potassium Metabisulfite
Kraft Chemical
Potassium Metabisulfite
Penta International
Penta International
Potassium Metabisulfite
For experimental / research use only.
Potassium Metabisulfite ≥98%
Wedor Corporation
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
antibrowning agents, antioxidants, preservatives
Recommendation for potassium metabisulfite usage levels up to:
 not for fragrance use.
Recommendation for potassium metabisulfite flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228) as food additives
View page or View pdf

Safety assessment of the active substance potassium metabisulfite, for use in active food contact materials
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):16731-55-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :28019
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
EPA/NOAA CAMEO:hazardous materials
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:16731-55-8
Pubchem (cid):28019
Pubchem (sid):135231029
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):D05581
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2832.20.0000
FDA Listing of Food Additive Status:View
•article of commerce contains approx 95% k2s2o5. •grades: technical; reagent; fcc.
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 dipotassium disulfite
 dipotassium disulphite
 dipotassium metabisulfite
 dipotassium oxidosulfanesulfonate oxide
 disulfurous acid potassium salt (1:2)
 disulfurous acid, dipotassium salt
 disulfurous acid, potassium salt (1:2)
 potassium disulfite
 potassium disulfite (K2S2O5)
 potassium metabisulphite
 potassium pyrosulfite
 pyrosulfurous acid dipotassium salt


PubMed:Crystal structure of potassium (1R)-d-ribit-1-yl-sulfonate.
PubMed:Occupational allergic contact dermatitis from potassium metabisulfite.
PubMed:Prevalence of sensitivity to food and drug additives in patients with chronic idiopathic urticaria.
PubMed:Clonal mast cell activation syndrome with anaphylaxis to sulfites.
PubMed:Laetiporus sulphureus, edible mushroom from Serbia: investigation on volatile compounds, in vitro antimicrobial activity and in situ control of Aspergillus flavus in tomato paste.
PubMed:Role of non-Saccharomyces yeasts in Korean wines produced from Campbell Early grapes: potential use of Hanseniaspora uvarum as a starter culture.
PubMed:Growth inhibitory effect of grape phenolics against wine spoilage yeasts and acetic acid bacteria.
PubMed:A novel method for controlling multicolored Asian lady beetle (Coleoptera: Coccinellidae) in vineyards.
PubMed:A palladium-catalyzed reaction of aryl halides, potassium metabisulfite, and hydrazines.
PubMed:Yeast ecology of vineyards within Marsala wine area (western Sicily) in two consecutive vintages and selection of autochthonous Saccharomyces cerevisiae strains.
PubMed:Sulfite species enhance carbon monoxide release from CO-releasing molecules: implications for the deoxymyoglobin assay of activity.
PubMed:Selective removal of the violet color produced by anthocyanins in procyanidin-rich unfermented cocoa extracts.
PubMed:The crystal structure of potassium (1S)-D-galactit-1-ylsulfonate.
PubMed:The concentration of ethyl carbamate in commercial ume (Prunus mume) liqueur products and a method of reducing it.
PubMed:Occupational airborne allergic contact dermatitis from potassium metabisulfite.
PubMed:The genotoxic effect of potassium metabisulfite using chromosome aberration, sister chromatid exchange, micronucleus tests in human lymphocytes and chromosome aberration test in bone marrow cells of rats.
PubMed:Evaluation of the inhibitory effect of dimethyl dicarbonate (DMDC) against wine microorganisms.
PubMed:Toxicity of corticosteroids and catecholamines for mice neuronal cell cultures: Role of preservatives.
PubMed:Antimicrobial activity of nisin against Oenococcus oeni and other wine bacteria.
PubMed:In Vivo PCR-DGGE analysis of Lactobacillus plantarum and Oenococcus oeni populations in red wine.
PubMed:Final report on the safety assessment of sodium sulfite, potassium sulfite, ammonium sulfite, sodium bisulfite, ammonium bisulfite, sodium metabisulfite and potassium metabisulfite.
PubMed:Effects of Drying Pretreatments on the Cell Wall Composition of Grape Tissues.
PubMed:Preservative-mediated changes of the surface properties of Escherichia coli.
PubMed:[Clinical aspects and diagnosis of sulfite intolerance. Apropos of 9 patients].
PubMed:Sulfite contact allergy.
PubMed:Sulfite-induced urticaria.
PubMed:Aflatoxin in betel nut and its control by use of food preservatives.
PubMed:Studies of neutrophil chemotactic factor of anaphylaxis in metabisulfite sensitivity.
PubMed:Prevalence of sensitivity to sulfiting agents in asthmatic patients.
PubMed:Positive skin tests and Prausnitz-K├╝stner reactions in metabisulfite-sensitive subjects.
PubMed:Effects of ethanol, potassium metabisulfite, formaldehyde and hydrogen peroxide on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine.
PubMed:The effect of white wine upon pulmonary function of asthmatic subjects.
PubMed:Adverse reactions to sulfites.
PubMed:Enhancing effects of dietary salt on both initiation and promotion stages of rat gastric carcinogenesis.
PubMed:Precipitating factors in asthma. Aspirin, sulfites, and other drugs and chemicals.
PubMed:Bronchospastic responses to aerosolized metabisulfite in asthmatic subjects: potential mechanisms and clinical implications.
PubMed:[Cysteine stability in aqueous amino acid solutions].
PubMed:[Use of alcian green in morphological and histochemical problems].
PubMed:Sulfite suppresses the mutagenic property of coffee.
PubMed:Sulfur balances in intravenously fed infants: effects of cysteine supplementation.
PubMed:The Microaerophile SPirillum volutans: Cultivation on Complex Liquid and Solid Media.
PubMed:Sensitivity to ingested metabisulfites in asthmatic subjects.
PubMed:Propionic acid-metabisulphite-Schiff reagent for quick Feulgen staining.
PubMed:[Digestive and metabolic utilization of dietary nitrogen in rats receiving tannic acid, sulfite and ethanol, administrated singly or in combination].
PubMed:Carcinogenicity test of potassium metabisulfite in mice.
PubMed:Improved Nissl method to stain formaldehyde or glutaraldehyde-fixed material.
PubMed:[Liver concentrations of water-soluble vitamins in rats treated, alone or in combination, with potassium metabisulfite, tannic acid, and ethanol].
PubMed:An improved acriflavine-Feulgen reagent for quantitative DNA cytofluorometry.
PubMed:[Methods for the demonstration of the basal membrane of the glomerular capillaries].
PubMed:[Various metabolic or toxic effects which can result from short term ingestion of sulfurous acid by the rat].
PubMed:[Intestinal and renal excretion of phosphorus and calcium in rats receiving potassium metabisulfite, tannic acid and ethanol, alone or in combination].
PubMed:[Effect of separated or simultaneous ingestion of tannic acid, potassium metabisulfite and ethanol on reproduction in rats].
PubMed:[Food additives and their possible genetic toxicity; microbiological determination].
PubMed:[Effects of tannic acid and potassium metabisulfite in combination with ethanol on some enzymatic detoxication activities of rat liver microsomes].
PubMed:[Effect of prolonged ingestion of tannic acid, potassium metabisulfite and ethanol, administered alone or in combination, on the liver vitamin A concentration in the rat].
PubMed:[Comparative effects of potassium metabisulfite and sodium metabisulfite on the dental caries in the rat].
PubMed:[Effect of potassium metabisulfite administration on hepatic storage of vitamin A in rats eating a vitamin A deficient diet].
PubMed:Allergic contact dermatitis caused by potassium metabisulfite.
PubMed:[Combination of potassium pyrosulfite and ethyl alcohol in drinking experiments in rats].
Food additive; preservative. Not permitted for meats, food sources of vitamin B1 or fresh fruit or vegetables
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