EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

2-propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester

Supplier Sponsors

CAS Number: 5466-77-3Picture of molecule3D/inchi
Other(deleted CASRN):155867-04-2
ECHA EINECS - REACH Pre-Reg:226-775-7
Nikkaji Web:J210.537C
Beilstein Number:5946632
XlogP3-AA:5.30 (est)
Molecular Weight:290.40282000
Formula:C18 H26 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:colorless to yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 405.00 to 406.00 °C. @ 760.00 mm Hg (est)
Flash Point: 341.00 °F. TCC ( 171.60 °C. ) (est)
logP (o/w): 5.921 (est)
Soluble in:
 water, 0.1548 mg/L @ 25 °C (est)
Insoluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: uv absorbers
uv filters
American International Chemical, LLC.
Octinoxate USP
BOC Sciences
For experimental / research use only.
Octinoxate ≥95%
Odor: characteristic
Use: Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms used in sunscreens and other cosmetics
ECSA Chemicals
Frinton Laboratories
For experimental / research use only.
Octyl p-Methoxycinnamate
Galaxy Surfactants
Galaxy 2932
Jiangyin Healthway
Octyl Methoxy Cinnamate (OMC)
New functional food ingredients
Lluch Essence
Odor: aromatic, balsamic
Penta International
Penta International
For experimental / research use only.
2-Ethylhexyl 4-methoxycinnamate analytical standard
Neo Heliopan® AV
Life Essentials - UV Protection
Odor: characteristic
Use: Neo Heliopan® AV is a highly effective oil-soluble UVB absorber with a specific extinction (E 1% / 1cm) of min. 830 at 308nm in methanol and has additional absorption in the short-wave UVA spectrum.
For experimental / research use only.
2-Ethylhexyl 4-methoxycinnamate >97.0%(GC)
TRI-K Industries
GalSorb OMC
Odor: characteristic
Use: A high purity, oil-soluble UVB absorber for premium sun care preparations. Functional and effective, it is the most popular UV-filter and one of the best available for use in the US sun care market.
Vigon International
Neo Heliopan AV (Ethyl Hexyl Para Methoxy Cinnamate)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic UV absorber
Recommendation for octinoxate usage levels up to:
 not for fragrance use.
Recommendation for octinoxate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):5466-77-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5355130
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate
EPA/NOAA CAMEO:hazardous materials
RTECS:UD3392732 for cas# 5466-77-3
 2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:5466-77-3
Pubchem (cid):5355130
Pubchem (sid):134986084
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D05225
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.99.4700
•uvinul mc 80: stabilized with 0.07+-0.02% bht and uvinul mc 80 n: unstabilized •shade uvaguard: avobenzone 3%, octinoxate 7.5%, oxybenzone 3% over the counter sunscreen topical lotion
Potential Blenders and core components note
None Found
Potential Uses:
 u.v. absorbers
Occurrence (nature, food, other):note
 not found in nature
 cinnamic acid, 4-methoxy-, 2-ethylhexyl ester
 escalol 557
2-ethyl hexyl 4-methoxycinnamate
2-ethyl hexyl-para-methoxycinnamate
2-ethylhexyl (2E)-3-(4-methoxyphenyl)-2-propenoate
2-ethylhexyl (2E)-3-(4-methoxyphenyl)acrylate
2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate
2-ethylhexyl 4-Methoxycinnamate
2-ethylhexyl p-methoxycinnamate
2-ethylhexyl trans-4-methoxycinnamate
 eusolex 2292
4-methoxycinnamic acid 2-ethylhexyl ester
3-(4-methoxyphenyl)-2-propenoic acid 2-ethylhexyl ester
3-(4-methoxyphenyl)-2-propenoic acid, 2-ethylhexyl ester
 neo heliopan (Symrise)
 neo heliopan AV (Symrise)
2-neo heliopan AV
 octinoxate USP (octyl methoxycinnamate)
 octyl 4-methoxycinnamate
 octyl methoxycinnamate
 octyl p-Methoxycinnamate
 octyl para-methoxycinnamate
 octyl-p-methoxy cinnamate USP
 OMC cinnamate
 parsol MCX
 parsol MOX
2-propenoic acid, 3- (4-methoxyphenyl)-, 2-ethylhexyl ester
2-propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester
2-propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester, (2E)-
 sunscreen AV
 uvinul 3088
 uvinul MC 80


US Patents:5,457,226 - Process for the manufacture of cinnamic acid derivatives
PubMed:Interaction mechanisms between organic UV filters and bovine serum albumin as determined by comprehensive spectroscopy exploration and molecular docking.
PubMed:Ecotoxicological evaluation of four UV filters using marine organisms from different trophic levels Isochrysis galbana, Mytilus galloprovincialis, Paracentrotus lividus, and Siriella armata.
PubMed:Triplet-triplet energy transfer from a UV-A absorber butylmethoxydibenzoylmethane to UV-B absorbers.
PubMed:Effects of four commonly used UV filters on the growth, cell viability and oxidative stress responses of the Tetrahymena thermophila.
PubMed:Effects of in vivo exposure to UV filters (4-MBC, OMC, BP-3, 4-HB, OC, OD-PABA) on endocrine signaling genes in the insect Chironomus riparius.
PubMed:Cosmetics as a potential source of environmental contamination in the UK.
PubMed:Simultaneous analysis and monitoring of 16 UV filters in cosmetics by high-performance liquid chromatography.
PubMed:Analysis of UV filters in tap water and other clean waters in Spain.
PubMed:Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin.
PubMed:Synthesis and evaluation of novel tetrapropoxycalix[4]arene enones and cinnamates for protection from ultraviolet radiation.
PubMed:Ionic liquid-based single-drop microextraction followed by liquid chromatography-ultraviolet spectrophotometry detection to determine typical UV filters in surface water samples.
PubMed:Field evaluation of three botanical repellents against Psorophora ferox, Aedes atlanticus, and Aedes mitchellae.
PubMed:Chronic actinic dermatitis: clinical cases, diagnostic workup, and therapeutic management.
PubMed:Polarographic determination of sunscreen agents in cosmetic products in micellar media.
PubMed:Uric acid photo-oxidation assay: in vitro comparison of sunscreening agents.
PubMed:Eco-friendly methodologies for the synthesis of some aromatic esters, well-known cosmetic ingredients.
PubMed:UV-screening chitosan nanocontainers: increasing the photostability of encapsulated materials and controlled release.
PubMed:Assessing retinol stability in a hydroquinone 4%/retinol 0.3% cream in the presence of antioxidants and sunscreen under simulated-use conditions: a pilot study.
PubMed:Simultaneous electrochemical determination of three sunscreens using cetyltrimethylammonium bromide.
PubMed:Transdermal penetration of UV filters.
PubMed:Monitoring 2-ethylhexyl-4-methoxycinnamate photoisomerization on skin using attenuated total reflection fourier transform infrared spectroscopy.
PubMed:Interactions between different solar UVB/UVA filters contained in commercial suncreams and consequent loss of UV protection.
PubMed:Sun protection strength of a hydroquinone 4%/retinol 0.3% preparation containing sunscreens.
PubMed:Synthesis and application of a novel sunscreen-antioxidant.
PubMed:Changes in ultraviolet absorbance and hence in protective efficacy against lipid peroxidation of organic sunscreens after UVA irradiation.
PubMed:Sunscreen penetration of human skin and related keratinocyte toxicity after topical application.
PubMed:Unexpected photolysis of the sunscreen octinoxate in the presence of the sunscreen avobenzone.
PubMed:Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.
PubMed:TiO2-promoted mineralization of organic sunscreens in water suspension and sodium dodecyl sulfate micelles.
PubMed:[Determination of 4 antiseptics and 6 sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography].
PubMed:The effect of UV absorbing sunscreens on the reflectance and the consequent protection of skin.
PubMed:Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation.
PubMed:Sunscreen allergy in Singapore.
PubMed:Sunscreens offer the same UVB protection factors for inflammation and immunosuppression in the mouse.
PubMed:Skin penetration and sun protection factor of ultra-violet filters from two vehicles.
PubMed:Relationship between the ability of sunscreens containing 2-ethylhexyl-4'-methoxycinnamate to protect against UVR-induced inflammation, depletion of epidermal Langerhans (Ia+) cells and suppression of alloactivating capacity of murine skin in vivo.
a sunscreen used for prevention of dna photodamage.
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