EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

1-amino-2-propanol
2-hydroxypropyl amine

Sponsors

Name:1-aminopropan-2-ol
CAS Number: 78-96-6Picture of molecule3D/inchi
Other:1674-56-2
ECHA EINECS - REACH Pre-Reg:201-162-7
FDA UNII:UE40BY1BZW
Nikkaji Web:J1.961E
Beilstein Number:0605275
MDL:MFCD00008139
XlogP3:-1.00 (est)
Molecular Weight:75.11093000
Formula:C3 H9 N O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food-contact surface of paper and paperboard
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1591 1-amino-2-propanol
FEMA Number:3965 1-amino-2-propanol
FDA Mainterm: 1-AMINO-2-PROPANOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00 sum of isomers
Food Chemicals Codex Listed: No
Specific Gravity:0.97000 to 0.97600 @ 25.00 °C.
Pounds per Gallon - (est).: 8.071 to 8.121
Refractive Index:1.44500 to 1.45100 @ 20.00 °C.
Melting Point: 24.00 to 26.00 °C. @ 760.00 mm Hg
Boiling Point: 160.00 to 161.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.470000 mm/Hg @ 25.00 °C.
Vapor Density:2.6 ( Air = 1 )
Flash Point: 165.00 °F. TCC ( 73.89 °C. )
logP (o/w): -0.960
Soluble in:
 alcohol
 water, 1.00E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: fishy
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
fishy
Odor Description:at 0.10 % in propylene glycol. fishy
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: buffering agents
 
Suppliers:
BASF
Monoisopropanolamine
BOC Sciences
For experimental / research use only.
DL-1-Amino-2-propanol Purity >98%
Connect Chemicals
Monoisopropanolamine (MIPA)
Dow Chemical
DOW Specialty Amines - Isopropanolamines
Penta International
1-AMINO-2-PROPANOL, Kosher
Sigma-Aldrich
DL-1-Amino-2-propanol, ≥90%
Certified Food Grade Products
TCI AMERICA
For experimental / research use only.
DL-1-Amino-2-propanol >98.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 23 - Do not breath vapour.
S 36 - Wear suitable protective clothing.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1715 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(7), Pg. 46, 1986.

intraperitoneal-mouse LDLo 250 mg/kg
BEHAVIORAL: EXCITEMENT
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 4, Pg. 232, 1952.

Dermal Toxicity:
skin-rabbit LD50 1640 ul/kg
Union Carbide Data Sheet. Vol. 5/21/1971

skin-mammal (species unspecified) LD50 > 1000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(7), Pg. 46, 1986.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: food-contact surface of paper and paperboard
Recommendation for 1-amino-2-propanol usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 20
 average usual ppmaverage maximum ppm
baked goods: 0.010000.10000
beverages(nonalcoholic): 0.030000.10000
beverages(alcoholic): 0.030000.10000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: 0.020000.20000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.020000.20000
fruit ices: --
gelatins / puddings: 0.020000.20000
granulated sugar: --
gravies: --
hard candy: 0.020000.20000
imitation dairy: --
instant coffee / tea: 0.005000.01000
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):78-96-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :4
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WISER:UN 2735
WGK Germany:1
1-aminopropan-2-ol
Chemidplus:0000078966
EPA/NOAA CAMEO:hazardous materials
RTECS:78-96-6
 
References:
 1-aminopropan-2-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:78-96-6
Pubchem (cid):4
Pubchem (sid):134971235
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C05771
HMDB (The Human Metabolome Database):HMDB12136
FooDB:FDB008936
Export Tariff Code:2922.19.5000
FDA Listing of Food Additive Status:View
Haz-Map:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 buffering agents
 
Occurrence (nature, food, other):note
 potato chip
Search PMC Picture
 
Synonyms:
(RS)-1-amino-2-hydroxypropane
1-amino-2-hydroxypropane
(±)-1-amino-2-propanol
(RS)-1-amino-2-propanol
1-amino-2-propanol
dextro,laevo-1-amino-2-propanol
DL-1-amino-2-propanol
1-amino-2-propanol tech. grade
alpha-aminoisopropyl alcohol
1-aminopropan-2-ol
2-hydroxy-1-propyl amine
2-hydroxy-1-propylamine
2-hydroxypropanamine
2-hydroxypropyl amine
1-methyl-2-aminoethanol
isopropanol amine
mono-isopropanol amine
2-propanol, 1-amino-
(±)-isopropanolamine
 threamine
 
 
Notes:
possible industrial pollutant. 1-Amino-2-propanol is a secondary amino alcohol. It can be prepared by the addition of aqueous ammonia to propylene oxide. It is an intermediate in the synthesis of a variety of pharmaceutical drugs and is the very basic building block of the opioid, methadone. It can be synthesized via Eschweiler-Clarke.(Wiki)
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