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disodium 5'-inosinate
disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate

Supplier Sponsors

Name:disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate
CAS Number: 4691-65-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:225-146-4
FDA UNII:T2ZYA7KC05
MDL:MFCD00150372
CoE Number:11895
Molecular Weight:392.17257056
Formula:C10 H11 N4 Na2 O8 P
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Additive: Disodium 5'-Inosinate
GSFA Codex: Disodium 5'-inosinate (631)
DG SANTE Food Additives:disodium inosinate
FEMA Number:3669 disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):4691-65-0 ; DISODIUM INOSINATE
FDA Regulation:
FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.120 Canned green beans and canned wax beans.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.130 Canned corn.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.170 Canned peas.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.200 Certain other canned vegetables.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.201 Canned mushrooms.


FDA PART 170 -- FOOD ADDITIVES
Subpart C--Specific Administrative Rulings and Decisions
Sec. 170.60 Nitrites and/or nitrates in curing premixes.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.535 Disodium inosinate.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 851.40 °C. @ 760.00 mm Hg (est)
Flash Point: 876.00 °F. TCC ( 468.70 °C. ) (est)
logP (o/w): -1.023 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, slightly
Insoluble in:
 ether
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: emollients
humectants
skin conditioning
 
Suppliers:
Ajinomoto USA
Ajitide™ Nucleotides
Flavor: characteristic
A premium line of nucleotides with the Ajinomoto touch which unlocks the taste characteristics of foods synergy with glutamates and other flavor enhancers nucleotides have.
BOC Sciences
For experimental / research use only.
Disodium 5'-inosinate
Carbosynth
For experimental / research use only.
Inosine 5'-monophosphate disodium salt hydrate
Kraft Chemical
I + G
Penta International
DISODIUM-5-INOSINATE
Prinova
Disodium Inosinate
Santa Cruz Biotechnology
For experimental / research use only.
Inosine 5'-monophosphate disodium salt hydrate
Sigma-Aldrich: Sigma
For experimental / research use only.
Inosine 5'-monophosphate disodium salt from muscle, Sigma Grade, 99-100%
Sinofi Food Ingredients
Disodium Inosinate (E631 Flavor Enhancer)
Flavor: characteristic
Flavour Enhancer, Instant Noodle, Pizza, Cheese, Snack Foods, Potato Chip, Crackers, Sauces, Fast Food, Baking Food, Ice Cream, Canned Food, Meats, Poultry, Sauces, Soups, Soft Candy, Puddings, Condiments, Snack Food, Fish, Seasonings.
TCI AMERICA
For experimental / research use only.
Inosine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)(E)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
R 02 - Risk of explosion by shock, friction, fire or other sources of ignition.
R 23/24 - Toxic by inhalation and in contact with skin.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 4850 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

oral-mouse LD50 12000 mg/kg
Tokyo Ika Daigaku Zasshi. Journal of Tokyo Medical College. Vol. 24, Pg. 553, 1966.

intravenous-mouse LD50 3300 mg/kg
Tokyo Ika Daigaku Zasshi. Journal of Tokyo Medical College. Vol. 24, Pg. 553, 1966.

intraperitoneal-mouse LD50 5400 mg/kg
Tokyo Ika Daigaku Zasshi. Journal of Tokyo Medical College. Vol. 24, Pg. 553, 1966.

intravenous-rat LD50 2730 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

oral-rat LD50 15900 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

Dermal Toxicity:
subcutaneous-mouse LD50 5480 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

subcutaneous-rat LD50 3900 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor enhancers
Recommendation for disodium 5'-inosinate usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
 average usual ppmaverage maximum ppm
baked goods: -141.00000
beverages(nonalcoholic): -220.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: -0.40000
chewing gum: --
condiments / relishes: -3200.00000
confectionery froastings: --
egg products: --
fats / oils: -2000.00000
fish products: -10.00000
frozen dairy: -3000.00000
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -660.00000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -314.00000
milk products: -46.00000
nut products: --
other grains: -240.00000
poultry: -200.00000
processed fruits: --
processed vegetables: -220.00000
reconstituted vegetables: -50.00000
seasonings / flavors: -1000.00000
snack foods: -50.00000
soft candy: -3000.00000
soups: -660.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the safety and efficacy of disodium 5'-ribonucleotides, disodium 5'-guanylate, disodium 5'-inosinate for all animal species and categories
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):4691-65-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :20819
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate
Chemidplus:0004691650
RTECS:NM7519500 for cas# 4691-65-0
 
References:
 disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:4691-65-0
Pubchem (cid):20819
Pubchem (sid):134984663
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
FooDB:FDB019972
Export Tariff Code:2934.99.9000
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emollients
 humectants
 skin conditioning
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ajitide nucleotides
 disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate
 disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methyl phosphate
 disodium 5'-O-phosphonatoinosine
 disodium 5'-ribonucleotide
 disodium 9-(5-O-phosphonato-b-D-ribofuranosyl)-9H-purin-6-ol
 disodium inosinate
 disodium inosine 5'-monophosphate
 disodium inosine 5'-phosphate
 disodium inosine-5'-monophosphate
 disodium-5-inosinate
 disodium-5'-inosinate
 IMP disodium salt
5'-imp disodium salt
 IMP sodium salt
5'-IMP-Na2
 Inosin-5'-monophosphate disodium
 inosine 5'-monophosphate disodium
 inosine 5'-monophosphate disodium salt
 inosine 5'-monophosphate disodium salt hydrate
 inosine 5'-monphosphate disodium salt
 inosine-5'-monophosphate disodium
5'-inosinic acid, sodium salt (1:2)
9H-purin-6-ol, 9-(5-O-phosphono-b-D-ribofuranosyl)-, sodium salt (1:2)
 sodium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)-tetrahydrofuran-2-yl)methyl phosphate
 sodium 5'-inosinate
 
 
Notes:
Flavour enhancer As it is a fairly expensive additive, it usually is not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.; Disodium inosinate (E631), chemical formula C10H11N2Na2O8P, is the disodium salt of inosinic acid. It is a food additive often found in instant noodles, potato chips, and a variety of other snacks. It is used as a flavor enhancer, in synergy with monosodium glutamate (also known as MSG; the sodium salt of glutamic acid) to provide the umami taste. It is mainly found in animals like pigs and fish.
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