disodium 5'-guanylate
disodium guanylate
 
Notes:
guanosine 5'-monophosphate. a guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. Flavour enhancer As it is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. It is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides.; Disodium guanylate (E627), also known as sodium 5'-guanylate and disodium 5'-guanylate, is the disodium salt of the flavor enhancer guanosine monophosphate (GMP). Disodium guanylate is a food additive and is commonly used in conjunction with glutamic acid (monosodium glutamate, MSG).
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      04-85700 DISODIUM-5-GUANYLATE, Kosher
       
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      Product(s):
      G0172 Guanosine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)(N)
       
Synonyms   Articles   Notes   Search
disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate (Click)
CAS Number: 5550-12-9Picture of molecule
ECHA EINECS - REACH Pre-Reg: 226-914-1
FDA UNII: B768T44Q8V
Beilstein Number: 3586801
MDL: MFCD00070575
CoE Number: 11772
Molecular Weight: 407.18754056
Formula: C10 H12 N5 Na2 O8 P
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Additive: Disodium 5'-Guanylate
GSFA Codex: Disodium 5'-guanylate (627)
DG SANTE Food Additives: disodium guanylate
FEMA Number: 3668  disodium 5'-guanylate
FDA Mainterm: DISODIUM GUANYLATE
FDA Regulation:
FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.120 Canned green beans and canned wax beans.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.130 Canned corn.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.170 Canned peas.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.200 Certain other canned vegetables.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.201 Canned mushrooms.


FDA PART 170 -- FOOD ADDITIVES
Subpart C--Specific Administrative Rulings and Decisions
Sec. 170.60 Nitrites and/or nitrates in curing premixes.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.530 Disodium guanylate.
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 890.20 °C. @ 760.00 mm Hg (est)
Flash Point: 918.00 °F. TCC ( 492.20 °C. ) (est)
logP (o/w): -0.423 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 ether
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
odorless
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: emollients
humectants
skin conditioning
Synonyms   Articles   Notes   Search   Top
Suppliers:
Ajinomoto USA
Ajitide™ Nucleotides
Flavor: characteristic
A premium line of nucleotides with the Ajinomoto touch which unlocks the taste characteristics of foods synergy with glutamates and other flavor enhancers nucleotides have.
Carbosynth
For experimental / research use only.
Guanosine 5'-monophosphate disodium salt
Changzhou Longo Chemical
Guanosine 5'-monophosphate disodium salt
Penta International
DISODIUM-5-GUANYLATE, Kosher
Prinova
GMP
Santa Cruz Biotechnology
For experimental / research use only.
Guanosine 5'-monophosphate disodium salt hydrate
Sigma-Aldrich: Sigma
For experimental / research use only.
Guanosine 5'-monophosphate disodium salt hydrate from yeast, ≥99%
Sinofi Ingredients
Disodium Guanylate (E627 Flavour Enhancer)
Flavor: characteristic
Flavour Enhancer, Instant Noodle, Pizza, Cheese, Snack Foods, Potato Chip, Crackers, Sauces, Fast Food, Baking Food, Ice Cream, Canned Food, Meats, Poultry, Sauces, Soups, Soft Candy, Puddings, Condiments, Seasonings.
TCI AMERICA
For experimental / research use only.
Guanosine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)(N)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50  3880 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

oral-mouse LD50  15000 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

intravenous-mouse LD50  3580 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

intraperitoneal-mouse LD50  5010 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

intravenous-rat LD50  2720 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

oral-rat LD50  > 17300 mg/kg
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

Dermal Toxicity:
subcutaneous-mouse LD50 5050 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

subcutaneous-rat LD50 3400 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Ajinomoto Co., Inc. Vol. -, Pg. -, 1973.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor enhancers
Recommendation for disodium 5'-guanylate usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
Click here to view publication 13
 average usual ppmaverage maximum ppm
baked goods: -143.00000
beverages(nonalcoholic): -2000.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: -0.40000
chewing gum: --
condiments / relishes: -3200.00000
confectionery froastings: --
egg products: --
fats / oils: -2000.00000
fish products: -10.00000
frozen dairy: -3000.00000
fruit ices: --
gelatins / puddings: -2000.00000
granulated sugar: --
gravies: -240.00000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -200.00000
milk products: -46.00000
nut products: --
other grains: -240.00000
poultry: -200.00000
processed fruits: --
processed vegetables: -140.00000
reconstituted vegetables: -150.00000
seasonings / flavors: -1000.00000
snack foods: -50.00000
soft candy: -3000.00000
soups: -720.00000
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety and efficacy of disodium 5'-ribonucleotides, disodium 5'-guanylate, disodium 5'-inosinate for all animal species and categories
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 5550-12-9
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 21712
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
Chemidplus: 0005550129
RTECS: MF9290000 for cas# 5550-12-9
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References:
 disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 5550-12-9
Pubchem (cid): 21712
Pubchem (sid): 134987267
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB001167
Export Tariff Code: 2934.99.9000
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 emollients 
 humectants 
 skin conditioning 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 ajitide nucleotides (guanylate)
 disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-imino-6-oxo-2,3,6,9-tetrahydro-1H-purin-9-yl)oxolan-2-yl]methyl phosphate
 disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
 disodium 2-amino-9-(5-O-phosphonato-b-D-ribofuranosyl)-9H-purin-6-ol
 disodium 5'-GMP
 disodium 5'-O-phosphonatoguanosine
 disodium GMP
 disodium guanosine 5'-monophosphate
 disodium guanosine-5'-monophosphate
 disodium guanylate
 disodium-5-guanylate
 disodium-5'-guanylate
 GMP
 GMP disodium salt
5'-GMP disodium salt
 GMP sodium salt
 guanosine 5'-(disodium phosphate)
 guanosine 5'-monophosphate disodium salt
 guanosine 5'-monophosphate disodium salt hydrate
 guanosine 5'-monophosphate, disodium salt
 guanosine 5'-phosphate disodium salt
 guanosine 5'MP, disodium salt
 guanosine5'-monophosphatedisodiumsalt
5-guanylic acid disodium salt
 guanylic acid sodium salt
5'-guanylic acid, sodium salt (1:2)
9H-purin-6-ol, 2-amino-9-(5-O-phosphono-β-D-ribofuranosyl)-, sodium salt (1:2)
 ribotide
 sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
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