EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

tributyl citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, tributyl ester

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Name:tributyl 2-hydroxypropane-1,2,3-tricarboxylate
CAS Number: 77-94-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-071-2
Nikkaji Web:J4.216A
Beilstein Number:1806072
XlogP3-AA:2.70 (est)
Molecular Weight:360.44744000
Formula:C18 H32 O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.03704 to 1.04700 @ 25.00 °C.
Pounds per Gallon - (est).: 8.629 to 8.712
Refractive Index:1.44300 @ 25.00 °C.
Melting Point: -20.00 °C. @ 760.00 mm Hg
Boiling Point: 170.00 °C. @ 1.00 mm Hg
Vapor Pressure:1.000000 mmHg @ 170.00 °C.
Vapor Density:12.4 ( Air = 1 )
Flash Point: 285.00 °F. TCC ( 140.56 °C. )
logP (o/w): 4.324 (est)
Soluble in:
 water, 27.37 mg/L @ 25 °C (est)
Insoluble in:
 will not support fungous grouth in resins
Organoleptic Properties:
Odor Strength:low
Substantivity:400 Hour(s)
Odor Description:at 100.00 %. herbal plastic
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: film formers
BOC Sciences
For experimental / research use only.
Tributyl citrate BP 233-234deg/17mm
Covalent Chemical
Tributyl Citrate
EMD Millipore
For experimental / research use only.
Tributyl Citrate
Jungbunzlauer Suisse
Odor: bland
Use: Citric acid esters have been available more than 40 years used in various applications. Initially, they found utility as plasticiser in polymers such as polyvinyl chloride (PVC) and cellulose derivates. In the meantime, their usefulness has grown into multiple applications with a growing demand as the trends for more environmentally friendly materials continues. Citrates offer an excellent alternative for those products under scrutiny. They demonstrate equal plasticiser performance to replace phthalates and adipates in many applications such as cosmetics, pharmaceutical coatings, food contact films and in plastic articles. Due to their high boiling point, plasticisers are hardly volatile, thus the losses from the polymers are insignificant. Their solvent power ensures compatibility with the resin. CITROFOL® BI is one of these plasticisers.
Sigma-Aldrich: Aldrich
For experimental / research use only.
Tributyl Citrate ≥97.0%
For experimental / research use only.
Tributyl Citrate >98.0%(GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 2900 mg/kg
Journal of Pharmaceutical Sciences. Vol. 53, Pg. 774, 1964.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for tributyl citrate usage levels up to:
 not for fragrance use.
Recommendation for tributyl citrate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
EPA Substance Registry Services (TSCA):77-94-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6507
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
tributyl 2-hydroxypropane-1,2,3-tricarboxylate
RTECS:TZ8608000 for cas# 77-94-1
 tributyl 2-hydroxypropane-1,2,3-tricarboxylate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6507
Pubchem (sid):134972807
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.15.5000
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 citric acid tri-N-butyl ester
 citric acid, tributyl ester
 citroflex 4
 dibutyl 3-(butoxycarbonyl)-3-hydroxypentane-1,5-dioate
2-hydroxy-1,2,3-propanetricarboxylate de tributyle
2-hydroxy-1,2,3-propanetricarboxylic acid, tributyl ester
1,2,3-propanetricarboxylic acid, 2-hydroxy-, tributyl ester
 tri-N-butyl citrate
 tributyl 2-hydroxy-1,2,3-propanetricarboxylate
 tributyl 2-hydroxypropane-1,2,3-tricarboxylate
1,2,3-tributyl 2-hydroxypropane-1,2,3-tricarboxylate


PubMed:Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites.
PubMed:Local demixion in plasticized polylactide probed by electron spin resonance.
PubMed:The effect of plasticizers on the erosion and mechanical properties of polymeric films.
PubMed:Optimization of focused ultrasonic extraction of propellant components determined by gas chromatography/mass spectrometry.
PubMed:Improved mechanical property and water resistance of zein films by plasticization with tributyl citrate.
PubMed:[Survey of plasticizers in polyvinyl chloride toys].
PubMed:Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion.
PubMed:Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor.
PubMed:Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan.
PubMed:Effect of ionising radiation treatment on the specific migration characteristics of packaging-food simulant combinations: effect of type and dose of radiation.
PubMed:Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods.
PubMed:Migration and hydrolysis of hydrophobic polylactide plasticizer.
PubMed:Occurrence of extractable ink residuals in packaging materials used in the Czech Republic.
PubMed:Guided tissue regeneration with bioabsorbable barriers III 10-year results in infrabony defects.
PubMed:Design and characterization of an adhesive matrix based on a poly(ethyl acrylate, methyl methacrylate).
PubMed:Fabrication and characterization of poly(lactic acid)/acetyl tributyl citrate/carbon black as conductive polymer composites.
PubMed:Determination of diethylhexyladipate and acetyltributylcitrate in aqueous extracts after cloud point extraction coupled with microwave assisted back extraction and gas chromatographic separation.
PubMed:Temporary restorative resins using non-phthalate ester plasticizers.
PubMed:Molecular biomarkers and adaptation to environmental stress in moon jelly (Aurelia spp.).
PubMed:Preparation and properties of plasticized poly(lactic acid) films.
PubMed:Controlled release of atenolol from the ethylene-vinyl acetate matrix.
PubMed:[Examination of sex-hormonal activity of some additives for PVDC film].
PubMed:Enhanced bioavailability of atenolol by transdermal administration of the ethylene-vinyl acetate matrix in rabbits.
PubMed:[Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products].
PubMed:Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan.
PubMed:[Contents of plasticizers in cap-sealing for bottled food and their migration into food].
PubMed:Polymerized rosin: novel film forming polymer for drug delivery.
PubMed:Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate.
PubMed:Cytocompatibility of new phthalate ester-free tissue conditioners in vitro.
PubMed:Self-adhesive thin films for topical delivery of 5-aminolevulinic acid.
PubMed:Influence of curing on the adhesive and thermomechanical properties of an applied acrylic polymer.
PubMed:Organic esters of plasticizers affecting the water absorption, adhesive property, glass transition temperature and plasticizer permanence of eudragit acrylic films.
PubMed:Guided tissue regeneration with bioabsorbable barriers: intrabony defects and class II furcations.
PubMed:The effects of plasticizers on the release of metoprolol tartrate from granules coated with a polymethacrylate film.
PubMed:Influence of surfactants in aqueous-based polymeric dispersions on the thermomechanical and adhesive properties of acrylic films.
PubMed:Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles.
PubMed:Tackiness of acrylic and cellulosic polymer films used in the coating of solid dosage forms.
PubMed:Effect of high-dose electron beam irradiation on the migration of DOA and ATBC plasticizers from food-grade PVC and PVDC/PVC films, respectively, into olive oil.
PubMed:Calculation of the dimensions of drug-polymer devices based on diffusion parameters.
PubMed:Acetyl tributyl citrate and dibutyl sebacate inhibit the growth of cultured mammalian cells.
PubMed:Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate/methacrylate copolymer latexes.
PubMed:Processing considerations for an EC latex coating system: influence of curing time and temperature.
PubMed:Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging.
PubMed:[Control of drug release from coated parenteral matrix-retard tablets using softening agents].
PubMed:In vitro release of therapeutically active ingredients from polymer matrixes.
PubMed:Pharmacological properties of the plasticizer, acetyl N-tributyl citrate, and its extraction from poly(vinyl chloride) tubing.
PubMed:Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate.
None found
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