EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ethyl nitrite
nitrous acid, ethyl ester

Supplier Sponsors

Name:ethyl nitrite
CAS Number: 109-95-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-722-6
FDA UNII:8C7CJ279RV
Nikkaji Web:J47.917I
Beilstein Number:1699562
MDL:MFCD00010257
CoE Number:11869
XlogP3-AA:0.40 (est)
Molecular Weight:75.06725000
Formula:C2 H5 N O2
NMR Predictor:Predict (works with chrome or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FEMA Number:2446-VOID ethyl nitrite
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):109-95-5 ; ETHYL NITRITE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.90090 @ 25.00 °C.
Boiling Point: 17.40 to 18.00 °C. @ 760.00 mm Hg
Vapor Pressure:905.966980 mmHg @ 25.00 °C. (est)
Flash Point: 59.00 °F. TCC ( 15.00 °C. )
logP (o/w): 0.712 (est)
Soluble in:
 alcohol
 water, 8968 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: ethereal
ethereal sweet rummy fruity
Odor Description:at 1.00 % in propylene glycol. ethereal sweet rummy fruity
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Ethyl Nitrite
Penta International
NITROUS ETHER 15% IN ETHANOL
Sigma-Aldrich: Aldrich
For experimental / research use only.
Ethyl nitrite solution 10-20 wt. % in ethanol
Synerzine
Ethyl Nitrite (15% in ethanol)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-rat LC50 160 ppm/4H
BEHAVIORAL: EXCITEMENT BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Fundamental and Applied Toxicology. Vol. 8, Pg. 101, 1987.

inhalation-cat LC > 200 mg/m3/1
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(1), Pg. 62, 1983.

inhalation-mouse LC > 200 mg/m3/1
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(1), Pg. 62, 1983.

 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for ethyl nitrite usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -0.10000
beverages(nonalcoholic): -3.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -3.90000
condiments / relishes: --
confectionery froastings: -13.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -4.50000
fruit ices: -4.50000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 0.100008.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):109-95-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8026
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1194
WGK Germany:1
ethyl nitrite
Chemidplus:0000109955
EPA/NOAA CAMEO:hazardous materials
 
References:
 ethyl nitrite
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:109-95-5
Pubchem (cid):8026
Pubchem (sid):134974013
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB31239
FooDB:FDB003266
Export Tariff Code:2920.90.5000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
article of commerce contains 90-95% ethyl nitrite, remainder is chiefly alcohol as preservative.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ethyl nitrite 15% in ethanol
 ethyl nitrite solution
 ethylnitrite
 hyponitrous ether
 nitrosyl ethoxide
 nitrous acid ethyl ester
 nitrous acid, ethyl ester
 nitrous ether
 nitrous ether 15% in ethanol
 nitrous ethyl ether
 spirit of nitrous ether
 sweet spirit of nitre
 

Articles:

PubMed:Chirped-Pulse millimeter-Wave spectroscopy for dynamics and kinetics studies of pyrolysis reactions.
PubMed:S-nitrosylation therapy to improve oxygen delivery of banked blood.
PubMed:Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death.
PubMed:A comparison of organic and inorganic nitrates/nitrites.
PubMed:Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage.
PubMed:Inclusion of a nitric oxide congener in the insufflation gas repletes S-nitrosohemoglobin and stabilizes physiologic status during prolonged carbon dioxide pneumoperitoneum.
PubMed:Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium.
PubMed:Formation of nitric oxide, ethyl nitrite and an oxathiolone derivative of caffeic acid in a mixture of saliva and white wine.
PubMed:Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols.
PubMed:[Effect of ethyl nitrite versus inhaled nitric oxide in a rat model of acute pulmonary hypertension].
PubMed:The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions.
PubMed:Transformation of ethyl alcohol to ethyl nitrite in acidified saliva: possibility of its occurrence in the stomach.
PubMed:Isomeric recognition by ion/molecule reactions: the ionized phenol-cyclohexadienone case.
PubMed:Ab initio, density functional theory, and continuum solvation model prediction of the product ratio in the S(N)2 reaction of NO2(-) with CH3CH2Cl and CH3CH2Br in DMSO solution.
PubMed:Efficacy of ethyl nitrite in reversing surgical vasospasm.
PubMed:Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats.
PubMed:Inclusion of an S-nitrosylating agent in the insufflating gas does not alter gastric activity in rats following pneumoperitoneum.
PubMed:A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
PubMed:Formation of ethyl nitrite in vivo after ethanol administration.
PubMed:A method to attenuate pneumoperitoneum-induced reductions in splanchnic blood flow.
PubMed:Fourier transform infrared-probed O(3P) microreactor: demonstration with ethylene reactions in argon matrix.
PubMed:The combined solid/solution-phase synthesis of nitrosamines: the evolution of the "libraries from libraries" concept.
PubMed:Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infants.
PubMed:Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn.
PubMed:Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics.
PubMed:Preparation and properties of S-nitroso-L-cysteine ethyl ester, an intracellular nitrosating agent.
PubMed:Synthesis, characterization, solid-state molecular structures, and deprotonation reactions of cationic alcohol complexes of osmium nitrosyl porphyrins.
PubMed:[A gas chromatographic method for detecting nitrites in the blood and stomach contents].
PubMed:Direct demonstration of NO formation in vivo from organic nitrites and nitrates, and correlation to effects on blood pressure and to in vitro effects.
PubMed:Oxidation of deoxyhemerythrin to semi-methemerythrin by nitrite.
PubMed:Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests.
PubMed:Oxidation of hemoglobin and myoglobin by alkyl nitrites inhibition by oxygen.
PubMed:Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
PubMed:Ethyl nitrite. The in vivo synthesis of a mutagenic substance from tobacco smoke and ethanol.
PubMed:Sudden death in an infant from methemoglobinemia after administration of "sweet spirits of nitre".
PubMed:[Acute poisoning due to inhalation of ethyl nitrite vapors].
 
Notes:
Flavouring ingredient The chemical compound ethyl nitrite is an alkyl nitrite. It may be prepared from ethanol:
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