EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

glycerine
glyceol

Sponsors

Flavor Demo Formulas
Name:propane-1,2,3-triol
CAS Number: 56-81-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-289-5
FDA UNII:PDC6A3C0OX
Nikkaji Web:J1.916J
Beilstein Number:0635685
MDL:MFCD00004722
CoE Number:11894
XlogP3:-1.80 (est)
Molecular Weight:92.09436000
Formula:C3 H8 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:solvents/deluents for cosmetic, flavor and/or fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
1975 Glycerin and Glycerides View-review
EU SANCO Glycerol View-review
JECFA Food Additive: Glycerol
GSFA Codex: Glycerol (422)
DG SANTE Food Additives:glyceol
DG SANTE Food Contact Materials:glyceol
FEMA Number:2525 glycerine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: GLYCERIN
FDA Regulation:
FDA PART 169 -- FOOD DRESSINGS AND FLAVORINGS
Subpart B--Requirements for Specific Standardized Food Dressings and Flavorings
Sec. 169.175 Vanilla extract.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.811 Glyceryl tristearate.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.320 Resinous and polymeric coatings for polyolefin films.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1390 Laminate structures for use at temperatures of 250 deg. F and above.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2420 Polyester resins, cross-linked.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2800 Textiles and textile fibers.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3500 Glycerin, synthetic.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart B--Multiple Purpose GRAS Food Substances
Sec. 182.1320 Glycerin.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.90 Substances migrating to food from paper and paperboard products.
 
Physical Properties:
Appearance:colorless clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity:1.25700 to 1.27000 @ 25.00 °C.
Pounds per Gallon - (est).: 10.459 to 10.568
Refractive Index:1.46700 to 1.48100 @ 20.00 °C.
Melting Point: 17.00 to 20.00 °C. @ 760.00 mm Hg
Boiling Point: 181.00 to 182.00 °C. @ 20.00 mm Hg
Boiling Point: 290.00 to 291.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000168 mm/Hg @ 25.00 °C.
Vapor Density:3.1 ( Air = 1 )
Flash Point: 320.00 °F. TCC ( 160.00 °C. )
logP (o/w): -1.850 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, 1e+006 mg/L @ 25 °C (est)
 water, 1.00E+06 mg/L @ 25 °C (exp)
Insoluble in:
 paraffin oil
 
Organoleptic Properties:
Odor Type: odorless
Odor Strength:none
Odor Description:at 100.00 %. odorless
Flavor Type: sweet
sweet
Taste Description: sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: denaturants
humectants
perfuming agents
solvents
 
Suppliers:
Acme-Hardesty
Glycerine 99.7%
Odor: characteristic
Use: Humectant, Intermediate, Excipient, Dispersant and Lubricant.
ADM
GLYCEROL
pharmaceutical grade glycerol 99.5 % acc. to EUR PH
Allan Chemical
Glycerine
American International Chemical, LLC.
GLYCERINE 99.7% USP KOSHER
BOC Sciences
For experimental / research use only.
Glycerol
Cargill, Inc.
Glycerin
Flavor: characteristic
Glycerin is a versatile compound that can come in both refined and crude form. Refined USP-grade glycerin can be used in many personal care, excipient, food, home care and industrial applications. USP glycerin offers moisturizing, emulsifying, and sweetening functionalities: it can be used to increase formulations’ density, viscosity and freezing point in a wide variety of applications.
Charkit Chemical
GLYCERINE USP 99.7%
Columbus Vegetable Oils
Glycerine Vegetable USP
Covalent Chemical
Glycerine USP Kosher
Croda
Pricerine™ 9091
Odor: bland
Use: Widely used humectant, dispersant, solvent and moisturiser.
Diffusions Aromatiques
GLYCERINE
ECSA Chemicals
Glycerol (86.5%, 99.5%)
Company Profile
EMD Millipore
For experimental / research use only.
Glycerol, Molecular Biology Grade
Foodchem International
Glycerol
Graham Chemical
Glycerine
Indenta Group
Glycerine
Kao Corporation
GLC99%
Kao Corporation
GLYCERIN(86%)(JP GRADE)
Odor: characteristic
Use: Cosmetics, pharmaceuticals, foods, tooth paste, tobaccos, paints, inks, paints, surface active agents, polyurethanes.
Kao Corporation
GLYCERIN(COSMETIC GRADE)
Odor: characteristic
Use: Cosmetics, pharmaceuticals, foods, tooth paste, tobaccos, paints, inks, paints, surface active agents, polyurethanes.
Kao Corporation
GLYCERIN(FOOD ADDITIVE)
Odor: characteristic
Use: Cosmetics, pharmaceuticals, foods, tooth paste, tobaccos, paints, inks, paints, surface active agents, polyurethanes.
Kao Corporation
GLYCERIN(JP GRADE)
Odor: characteristic
Use: Material for cosmetics, pharmaceuticals, foods, tooth pastes, paints, inks, pigments. Raw materials for surfactants, polyurethane resins.
Kao Corporation
REFINED GLYCERIN
Odor: characteristic
Use: Cosmetics, pharmaceuticals, foods, tooth paste, tobaccos, paints, inks, paints, surface active agents, polyurethanes.
Kingyoung Bio Technical
Glycerine
Kraft Chemical
Glycerine
Liberty Natural Products
GLYCERINE VEGETABLE MALAYSIA
Lluch Essence
GLYCERINE NATURAL 99,5% USP
Oleo Solutions
Glycerine
Odor: characteristic
Use: Flavours and Fragrances, Cosmetics and Personal Care, Cleaning and Detergents, Adhesives and Lubricants, Industrial, Inks and Coatings, Pharmaceutical and Veterinary
P&G Chemicals
Glycerine
Penta International
GLYCERINE FCC, Kosher
Penta International
GLYCERINE NATURAL USP/EP/BP/JP GRADE, Kosher
Penta International
GLYCERINE REGULAR GRADE, Kosher
Penta International
GLYCERINE U.S.P., Kosher
Penta International
GLYCERINE, NATURAL, Kosher
Prinova
Glycerine
Santa Cruz Biotechnology
For experimental / research use only.
Glycerol ≥99.5%
Sigma-Aldrich
Glycerol, >99%, FCC, FG
Certified Food Grade Products
Silver Fern Chemical
Glycerine / USP Glycerin
Silver Fern Chemical
Glycerine USP/K
Odor: characteristic
Use: Glycerine USP Kosher is used in a variety of personal care and pharmaceutical applications, as well as food and beverage products.
Soapers Choice
GLYCERINE 99.7% USP-95636SC
Odor: characteristic
Use: Vegetable Glycerine, or Glycerol, is USP grade with verified purity. It is a clear, odorless liquid exclusively produced from the hydrolysis of vegetable oils. Vegetable Glycerine has a number of valuable applications that include cosmetic products, foods, and herbal tinctures. This product is sourced and manufactured in Malaysia. Vegetable Glycerine is considered Vegan, Lactose Free, Gluten Free, Glutamate Free, BSE Free, No Hydrogenated or Partially Hydrogenated Oils, No Preservatives. this material is not from the biodiesel process.
Soapers Choice
GLYCERINE SOAP BASE - CLEAR-96025SC
Odor: characteristic
Use: Glycerin Soap Base Clear is a clear and natural soap base that contains no detergents, no surfactants, no sulfates, no alcohol, and no sugar solutions. Coconut oil, known as an excellent skin moisturizer, is the main ingredient in this base. This base, because of it's clarity is fun and can produce brightly colored soaps. It is great for colorants and fragrance oils that are safe for soaps and skin products.
Soapers Choice
GLYCERINE SOAP BASE - WHITE-96125SC
Odor: characteristic
Use: Glycerin Soap Base White is terrific for creating your own soap without the wait involved with Cold Process. Melt and pour soapmaking also allows for a wide range of creativity. This is opaque (white) - you cannot see through it and has the same high quality as our other melt and pour bases. This is an excellent skin moisturizer.
Soapers Choice
GLYCERINE SOAP BASE GOATS MILK-96224SC
Odor: characteristic
Use: Glycerine Soap Base Goats Milk contains real goat milk, which is thought to be moisturizing to the skin. The color is light ivory, and they are low sweat soap bases.
Soapers Choice
GLYCERINE SOAP BASE SHEA-96824SC
Odor: characteristic
Use: Soap Base Shea is a white soap base with added shea butter. It gives off a creamy lather while promoting moisture and softening.
Soapers Choice
GLYCERINE USP 99.7%-95610SC
Odor: characteristic
Use: Vegetable Glycerine, or Glycerol, is USP grade with verified purity. It is a clear, odorless liquid exclusively produced from the hydrolysis of vegetable oils. Vegetable Glycerine has a number of valuable applications that include cosmetic products, foods, and herbal tinctures. This product is sourced and manufactured in Malaysia. Vegetable Glycerine is considered Vegan, Lactose Free, Gluten Free, Glutamate Free, BSE Free, No Hydrogenated or Partially Hydrogenated Oils, No Preservatives. this material is not from the biodiesel process.
TCI AMERICA
For experimental / research use only.
Glycerol [Matrix for FABMS and liquid SIMS] >99.0%(GC)
The Perfumers Apprentice
Vegetable Glycerin (VG)
Vigon International
Glycerine Natural 99.5%
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36 - Irritating to eyes.
S 02 - Keep out of the reach of children.
S 25 - Avoid contact with eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/39 - Wear suitable clothing and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 12600 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC LIVER: OTHER CHANGES BEHAVIORAL: MUSCLE WEAKNESS
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.

intravenous-rat LD50 5566 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.

intraperitoneal-rat LD50 4420 mg/kg
CARDIAC: OTHER CHANGES BEHAVIORAL: TOXIC PSYCHOSIS KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Research Communications in Chemical Pathology and Pharmacology. Vol. 56, Pg. 125, 1987.

oral-rabbit LD50 27000 mg/kg
Delaware State Medical Journal. Vol. 31, Pg. 276, 1959.

intravenous-rabbit LD50 53000 mg/kg
Drugs in Japan Vol. 6, Pg. 215, 1982.

oral-mouse LD50 4090 mg/kg
Farmatsevtichnii Zhurnal Vol. (6), Pg. 56, 1977.

intravenous-mouse LD50 4250 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 583, 1950.

intraperitoneal-mouse LD50 8700 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1579, 1978.

oral-guinea pig LD50 7750 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

oral-human LDLo 1428 mg/kg
BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 288, 1969.

Dermal Toxicity:
skin-rabbit LD50 > 10000 mg/kg
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 9-4/1970

subcutaneous-rat LD50 100 mg/kg
Drugs in Japan Vol. 6, Pg. 215, 1982.

subcutaneous-mouse LD50 91 mg/kg
Drugs in Japan Vol. 6, Pg. 215, 1982.

Inhalation Toxicity:
inhalation-rat LC50 > 570 mg/m3/1H
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 9-4/1970

 
Safety in Use Information:
Category: solvents/deluents for cosmetic, flavor and/or fragrance agents
Recommendation for glycerine usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -1300.00000
beverages(nonalcoholic): -570.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 17.000006000.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -500.00000
fruit ices: -500.00000
gelatins / puddings: -360.00000
granulated sugar: --
gravies: --
hard candy: -980.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -40.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of glycerol (E 422) as a food additive
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):56-81-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :753
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
propane-1,2,3-triol
Chemidplus:0000056815
EPA/NOAA CAMEO:hazardous materials
RTECS:56-81-5
 
References:
 propane-1,2,3-triol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:56-81-5
Pubchem (cid):753
Pubchem (sid):134972920
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00116
HMDB (The Human Metabolome Database):HMDB00131
FooDB:FDB000756
YMDB (Yeast Metabolome Database):YMDB00283
Export Tariff Code:2905.45.0000
Haz-Map:View
Household Products:Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 denaturants
 humectants
 solvents
 
Occurrence (nature, food, other):note
 anise
Search Trop Picture
 avocado fruit
Search Trop Picture
 cacao plant
Search Trop Picture
 corn plant
Search Trop Picture
 dandelion latex
Search Trop Picture
 pomegranate twig
Search Trop Picture
 wheat seed
Search Trop Picture
 
Synonyms:
 bulbold
 cristal
 glyceol
 glycerin
 glycerin organic
 glycerine 99.5 USP
 glycerine 99.7 USP
 glycerine FCC
 glycerine natural USP/EP/BP/JP grade
 glycerine regular grade
 glycerine U.S.P.
 glycerine, natural
 glycerol
3H-glycerol
 glycyl alcohol
 mackstat H 66
 pricerine 9091
 propan-1,2,3-triol
1,2,3-propane triol
 propane-1,2,3-triol
1,2,3-propanetriol
 trihydroxypropane
1,2,3-trihydroxypropane
 tryhydroxypropane
 zilgel Oil
 zilgel SM
 zilgel VV
 

Articles:

PubMed:Assessment of the physical, mechanical, and moisture-retention properties of pullulan-based ternary co-blended films.
PubMed:Effect of temperature on Chinese rice wine brewing with high concentration presteamed whole sticky rice.
PubMed:Innovations in the brewing industry: light beer.
PubMed:Development of shelf-stable, ready-to-eat (RTE) shrimps ( Litopenaeus vannamei ) using water activity lowering agent by response surface methodology.
PubMed:An NMR-based metabolomics study of pork from different crossbreeds and relation to sensory perception.
PubMed:Osmotic stress response in the wine yeast Dekkera bruxellensis.
PubMed:Pharmaceutical optimization of lipid-based dosage forms for the improvement of taste-masking, chemical stability and solubilizing capacity of phenobarbital.
PubMed:Glycerol, an underestimated flavor precursor in the Maillard reaction.
PubMed:Polymer characterization and optimization of conditions for the enhanced bioproduction of benzaldehyde by Pichia pastoris in a two-phase partitioning bioreactor.
PubMed:Evaluation of gene modification strategies for the development of low-alcohol-wine yeasts.
PubMed:Construction of self-cloning, indigenous wine strains of Saccharomyces cerevisiae with enhanced glycerol and glutathione production.
PubMed:Metabolomics-based component profiling of hard and semi-hard natural cheeses with gas chromatography/time-of-flight-mass spectrometry, and its application to sensory predictive modeling.
PubMed:Wine flavor and aroma.
PubMed:Assessment of palatability of two sublingual diluents in allergic patients: a prospective pilot study.
PubMed:Effect of antifungal hydroxypropyl methylcellulose-lipid edible composite coatings on Penicillium decay development and postharvest quality of cold-stored "Ortanique" mandarins.
PubMed:Characterization of Chinese liquor starter, "Daqu", by flavor type with 1H NMR-based nontargeted analysis.
PubMed:Engineering of 2,3-butanediol dehydrogenase to reduce acetoin formation by glycerol-overproducing, low-alcohol Saccharomyces cerevisiae.
PubMed:Volatile and color composition of young and model-aged Shiraz wines as affected by diammonium phosphate supplementation before alcoholic fermentation.
PubMed:The aroma side of the Maillard reaction.
PubMed:Enological characterization of natural hybrids from Saccharomyces cerevisiae and S. kudriavzevii.
PubMed:Toxicological evaluation of glycerin as a cigarette ingredient.
PubMed:Gas chromatographic/mass spectrometric determination of 3-methoxy-1,2-propanediol and cyclic diglycerols, by-products of technical glycerol, in wine: interlaboratory study.
PubMed:Determination of esterolytic and lipolytic activities of lactic acid bacteria.
PubMed:Carcass, sensory, and adipose tissue traits of Brangus steers fed casein-formaldehyde-protected starch and/or canola lipid.
PubMed:Production, purification, characterization, and applications of lipases.
PubMed:Microencapsulation of water-soluble isoflavone and physico-chemical property in milk.
PubMed:Heterocyclic acetals from glycerol and acetaldehyde in Port wines: evolution with aging.
PubMed:Effect of threonine, cystathionine, and the branched-chain amino acids on the metabolism of Zygosaccharomyces rouxii*
PubMed:Kinetic analysis of yeast inactivation by high pressure treatment at low temperatures.
PubMed:A critical evaluation of the glycerol test in Ménière's disease.
PubMed:[Intermediate moisture foods: polysaccharide and protein gels].
 
Notes:
a trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. it is used as a solvent, emollient, pharmaceutical agent, and sweetening agent. Found extensively in esterified form in animal and plant glycerides. Humectant, emollient and solvent in foods Glycerol (or glycerin, glycerine) is a simple polyol compound. It is a colorless, odorless, viscous liquid that is widely used in pharmaceutical formulations. The glycerol backbone is central to all lipids known as triglycerides. Glycerol is sweet-tasting and of low toxicity. (Wikipedia)
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