iron-depleted form of Lactoferrin
None found
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Category: antioxidant, emollients, hair conditioning
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
hair conditioning
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 None found
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidant, emollients, hair conditioning
Recommendation for apo-lactoferrin usage levels up to:
 not for fragrance use.
Recommendation for apo-lactoferrin flavor usage levels up to:
 not for flavor use.
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Safety References:
None found
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None found
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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 iron-depleted form of Lactoferrin
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PubMed: Potential of lactoferrin to prevent antibiotic-induced Clostridium difficile infection.
PubMed: Combined effects of lactoferrin and lysozyme on Streptococcus pneumoniae killing.
PubMed: Antiviral activities of whey proteins.
PubMed: Lactoferrin-loaded contact lenses: eye protection against oxidative stress.
PubMed: A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors.
PubMed: The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences.
PubMed: Identification of unprecedented anticancer properties of high molecular weight biomacromolecular complex containing bovine lactoferrin (HMW-bLf).
PubMed: Effect of bovine apo-lactoferrin on the growth and virulence of Actinobacillus pleuropneumoniae.
PubMed: Structure of the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut.
PubMed: Lactoferrin directly scavenges hydroxyl radicals and undergoes oxidative self-degradation: a possible role in protection against oxidative DNA damage.
PubMed: Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles.
PubMed: A high-throughput method for the quantification of iron saturation in lactoferrin preparations.
PubMed: Selenium compound protects corneal epithelium against oxidative stress.
PubMed: Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha.
PubMed: The transfer of iron between ceruloplasmin and transferrins.
PubMed: Apo- and holo-lactoferrin stimulate proliferation of mouse crypt cells but through different cellular signaling pathways.
PubMed: Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells.
PubMed: Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events.
PubMed: Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin.
PubMed: Effect of apolactoferrin on experimental pneumococcal otitis media.
PubMed: Effect of bovine lactoferrin addition to milk in yogurt manufacturing.
PubMed: Use and endocytosis of iron-containing proteins by Entamoeba histolytica trophozoites.
PubMed: 28-Day repeated dose oral toxicity of recombinant human apo-lactoferrin or recombinant human lysozyme in rats.
PubMed: IsdA protects Staphylococcus aureus against the bactericidal protease activity of apolactoferrin.
PubMed: Thiophilic interaction chromatography of mammalian and avian transferrins.
PubMed: Apolactoferrin inhibits the catalytic domain of matrix metalloproteinase-2 by zinc chelation.
PubMed: Amoebicidal activity of milk, apo-lactoferrin, sIgA and lysozyme.
PubMed: Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae.
PubMed: Human hololactoferrin: endocytosis and use as an iron source by the parasite Entamoeba histolytica.
PubMed: PspA protects Streptococcus pneumoniae from killing by apolactoferrin, and antibody to PspA enhances killing of pneumococci by apolactoferrin [corrected].
PubMed: Growth-promoting effects of lactoferrin on L. acidophilus and Bifidobacterium spp.
PubMed: Lactoferrin and iron: structural and dynamic aspects of binding and release.
PubMed: Human apo-lactoferrin enhances angiogenesis mediated by vascular endothelial growth factor A in vivo.
PubMed: In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice.
PubMed: Tertiary structural changes associated with iron binding and release in hen serum transferrin: a crystallographic and spectroscopic study.
PubMed: In vitro growth responses of bifidobacteria and enteropathogens to bovine and human lactoferrin.
PubMed: In vitro characterization of lactoferrin aggregation and amyloid formation.
PubMed: Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products.
PubMed: Lactoferrin iron levels affect attachment of Actinobacillus actinomycetemcomitans to buccal epithelial cells.
PubMed: Crystal structure of equine apolactoferrin at 303 K providing further evidence of closed conformations of N and C lobes.
PubMed: Involvement of bovine lactoferrin metal saturation, sialic acid and protein fragments in the inhibition of rotavirus infection.
PubMed: Protein intermediate trapped by the simultaneous crystallization process. Crystal structure of an iron-saturated intermediate in the Fe3+ binding pathway of camel lactoferrin at 2.7 a resolution.
PubMed: Camel lactoferrin, a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2.6 A resolution and structural basis of its dual role.
PubMed: Inhibitory effect of lactoferrin on the adhesion of Prevotella nigrescens ATCC 25261 to hydroxyapatite.
PubMed: Transferrins: iron release from lactoferrin.
PubMed: Metal complexes of lactoferrin and their effect on the intracellular multiplication of Legionella pneumophila.
PubMed: Structure of mare apolactoferrin: the N and C lobes are in the closed form.
PubMed: Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change. addendum
PubMed: Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change.
PubMed: Growth responses of coliform bacteria to purified immunoglobulin G from cows immunized with ferric enterobactin receptor FepA.
PubMed: Antiviral effect of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection.
PubMed: Bovine lactoferrin and Lactoferricin inhibit tumor metastasis in mice.
PubMed: Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin.
PubMed: Synergic antistaphylococcal properties of lactoferrin and lysozyme.
PubMed: Transferrins--a mechanism for iron uptake by lactoferrin.
PubMed: The pH-induced release of iron from transferrin investigated with a continuum electrostatic model.
PubMed: Inhibition of in vitro growth of coliform bacteria by a monoclonal antibody directed against ferric enterobactin receptor FepA.
PubMed: Antirotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29.
PubMed: The antifungal effect of lactoferrin and lysozyme on Candida krusei and Candida albicans.
PubMed: An estrogen inducible 104 kDa chaperone glycoprotein binds ferric iron containing proteins: a possible role in intracellular iron trafficking.
PubMed: Human lactoferrin receptor activity in non-encapsulated Haemophilus influenzae.
PubMed: Transferrin--interactions of lactoferrin with hydrogen carbonate.
PubMed: Augmented inhibition of growth of Candida albicans by neutrophils in the presence of lactoferrin.
PubMed: Relationship between antibacterial activity and cell surface binding of lactoferrin in species of genus Micrococcus.
PubMed: Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice.
PubMed: Lactoferrin as a suppressor of cell migration of gastrointestinal cell lines.
PubMed: Compact growth of Staphylococcus haemolyticus in soft agar is not due to hydrophobic interaction between the cocci.
PubMed: Antibacterial activity of peptides homologous to a loop region in human lactoferrin.
PubMed: Immobilized metal ion affinity chromatography.
PubMed: Growth inhibitory effects of bovine lactoferrin to Toxoplasma gondii parasites in murine somatic cells.
PubMed: Preparation of apolactoferrin with a very low iron saturation.
PubMed: Modulation of the anti-Candida activity of apo-lactoferrin by dietary sucrose and tunicamycin in vitro.
PubMed: The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin.
PubMed: Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi.
PubMed: Iron-induced conformational change in human lactoferrin: demonstration by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and analysis of effects of iron binding to the N and C lobes of the molecule.
PubMed: Protein-binding Properties of two Antitumour Ru(III) Complexes to Human Apotransferrin and Apolactoferrin.
PubMed: Kinetic parameters for the heat denaturation of bovine lactoferrin in milk, and its effect on interaction with monocytes.
PubMed: A comparison of the three-dimensional structures of human lactoferrin in its iron free and iron saturated forms.
PubMed: Antimicrobial peptides of lactoferrin.
PubMed: Three-dimensional structure of lactoferrin in various functional states.
PubMed: Proposed mechanisms for the involvement of lactoferrin in the hydrolysis of nucleic acids.
PubMed: The fungicidal effect of human lactoferrin on Candida albicans and Candida krusei.
PubMed: Thermal behavior of bovine lactoferrin in water and its relation to bacterial interaction and antibacterial activity.
PubMed: Iron binding to human lactoferrin alters reactivity of the protein with plant lectins.
PubMed: Forms of lactoferrin: their antibacterial effect on enterotoxigenic Escherichia coli.
PubMed: Effect of heat treatment and other milk proteins on the interaction of lactoferrin with monocytes.
PubMed: Influence of lactoferrin on the entry process of Escherichia coli HB101 (pRI203) in HeLa cells.
PubMed: Agglutination of Streptococcus mutans serotype C cells but inhibition of Porphyromonas gingivalis autoaggregation by human lactoferrin.
PubMed: Nitric oxide interaction with lactoferrin and its production by macrophage cells studied by EPR and spin trapping.
PubMed: Preliminary crystallographic studies of the amino terminal half of human lactoferrin in its iron-saturated and iron-free forms.
PubMed: Interaction of lactoferrin and lipopolysaccharide (LPS): effects on the antioxidant property of lactoferrin and the ability of LPS to prime human neutrophils for enhanced superoxide formation.
PubMed: High-performance liquid chromatographic separation of human apolactoferrin and monoferric and diferric lactoferrins.
PubMed: Different profiles of induced cotton effects of human and bovine lactoferrin by cibacron blue F3GA binding.
PubMed: Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes.
PubMed: Apotransferrins from several species promote thyroid hormone-dependent rat pituitary tumor cell growth in iron-restricted serum-free defined culture.
PubMed: Fungicidal effect of human lactoferrin against Candida albicans.
PubMed: Uptake of lactoferrin by mononuclear phagocytes inhibits their ability to form hydroxyl radical and protects them from membrane autoperoxidation.
PubMed: Binding and endocytosis of apo- and holo-lactoferrin by isolated rat hepatocytes.
PubMed: Molecular replacement solution of the structure of apolactoferrin, a protein displaying large-scale conformational change.
PubMed: Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila.
PubMed: Pseudomonas and neutrophil products modify transferrin and lactoferrin to create conditions that favor hydroxyl radical formation.
PubMed: Structure, function and flexibility of human lactoferrin.
PubMed: Metal ligand-induced alterations in the surface structures of lactoferrin and transferrin probed by interaction with immobilized copper(II) ions.
PubMed: Prooxidant activity of transferrin and lactoferrin.
PubMed: Iron is not required in the lactoferrin stimulation of thymidine incorporation into the DNA of rat crypt enterocytes.
PubMed: Apolactoferrin structure demonstrates ligand-induced conformational change in transferrins.
PubMed: Differential interaction of peptides and protein surface structures with free metal ions and surface-immobilized metal ions.
PubMed: Growth of gram-negative bacteria in dry cow secretion.
PubMed: Interaction of lactoferrin with Escherichia coli cells and correlation with antibacterial activity.
PubMed: Rapid purification of porcine colostral whey lactoferrin by affinity chromatography on single-stranded DNA-agarose. Characterization, amino acid composition and N-terminal amino acid sequence.
PubMed: Interaction of human lactoferrin with DNA: one-step purification by affinity chromatography on single-stranded DNA-agarose.
PubMed: Preliminary crystallographic studies on human apo-lactoferrin in its native and deglycosylated forms.
PubMed: Growth and adsorption of Streptococcus mutans 6715-13 to hydroxyapatite in the presence of lactoferrin.
PubMed: The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin.
PubMed: Characterization of the human transferrin and lactoferrin receptors in Haemophilus influenzae.
PubMed: Identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis.
PubMed: Susceptibilities of lactoferrin and transferrin to myeloperoxidase-dependent loss of iron-binding capacity.
PubMed: Iron metabolism in BeWo chorion carcinoma cells. Transferrin-mediated uptake and release of iron.
PubMed: Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?
PubMed: Bactericidal effect of lactoferrin on Legionella pneumophila.
PubMed: In vitro growth of mastitis-associated streptococci in bovine mammary secretions.
PubMed: Effect of iron chelators on the transferrin receptor in K562 cells.
PubMed: Evidence for a role of hydroxyl radical in immune-complex-induced vasculitis.
PubMed: Inhibition of mastitic bacteria by bovine milk apo-lactoferrin evaluated by in vitro microassay of bacterial growth.
PubMed: Kinetic effect of human lactoferrin on the growth of Escherichia coli 0111.
PubMed: Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron.
PubMed: The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum. Unusual resistance of human apolactoferrin to proteolytic digestion.
PubMed: Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.
PubMed: Suppression of mouse myelopoiesis by administration of human lactoferrin in vivo and the comparative action of human transferrin.
PubMed: Spectroscopic studies on copper (II) complexes of human lactoferrin.
PubMed: Transferrin receptors of human fibroblasts. Analysis of receptor properties and regulation.
PubMed: Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation.
PubMed: Studies on human lactoferrin by electron paramagnetic resonance, fluorescence, and resonance Raman spectroscopy.
PubMed: Lactoferrin turnover in man.
PubMed: A bactericidal effect for human lactoferrin.
PubMed: In vitro growth inhibition of mastitis-causing coliform bacteria by bovine apo-lactoferrin and reversal of inhibition by citrate and high concentrations of apo-lactoferin.
PubMed: The effect of trypsin on bovine transferrin and lactoferrin.
PubMed: The involvement of lactoferrin in the hyposideremia of acute inflammation.
PubMed: Association of lactoferrin with other proteins, as demonstrated by changes in electrophoretic mobility.
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