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enzyme produced by the fermentation of serratia marcescens

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CAS Number: 37312-62-2
ECHA EC Number:253-457-5
FDA UNII: Search
Category:emollients, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data2
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
skin conditioning - emollient
BOC Sciences
For experimental / research use only.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 15200 ug/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

intravenous-mouse LD50 14230 ug/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

oral-mouse LD50 > 2500 mg/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

intraperitoneal-rat LD50 34620 ug/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

intravenous-rat LD50 6950 ug/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

oral-rat LD50 > 2500 mg/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

Dermal Toxicity:
subcutaneous-mouse LD50 44 mg/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

subcutaneous-rat LD50 89 mg/kg
Drugs in Japan Vol. 6, Pg. 415, 1982.

Inhalation Toxicity:
Not determined
Safety in Use Information:
emollients, skin conditioning
Recommendation for serralysin usage levels up to:
 not for fragrance use.
Recommendation for serralysin flavor usage levels up to:
 not for flavor use.
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
Pubchem (sid):135331284
Other Information:
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 serratia marcescens
Search Trop Picture
 enzyme produced by the fermentation of serratia marcescens
 serratia marcescens ferment


PubMed:Pathogenicity of Isolates of Serratia Marcescens towards Larvae of the Scarab Phyllophaga Blanchardi (Coleoptera).
J-Stage:Regulation of Chitinase Production by the 5'-Untranslated Region of the ybfM in Serratia marcescens 2170
PubMed:Identification of SlpB, a Cytotoxic Protease from Serratia marcescens.
PubMed:Virulence factors contributing to invasive activities of Serratia grimesii and Serratia proteamaculans.
PubMed:Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors.
PubMed:Molecular detection and analysis of a novel metalloprotease gene of entomopathogenic Serratia marcescens strains in infected Galleria mellonella.
PubMed:Assessing the exoproteome of marine bacteria, lesson from a RTX-toxin abundantly secreted by Phaeobacter strain DSM 17395.
PubMed:Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori.
PubMed:Serratia marcescens suppresses host cellular immunity via the production of an adhesion-inhibitory factor against immunosurveillance cells.
PubMed:A fibrinolytic, alkaline and thermostable metalloprotease from the newly isolated Serratia sp RSPB11.
PubMed:In vivo monitoring of Yersinia ruckeri in fish tissues: progression and virulence gene expression.
PubMed:Phylogeny of bacteria isolated from Rhabditis sp. (Nematoda) and identification of novel entomopathogenic Serratia marcescens strains.
PubMed:Mutation of crp mediates Serratia marcescens serralysin and global secreted protein production.
PubMed:Comparison of the binding specificity of two bacterial metalloproteases, LasB of Pseudomonas aeruginosa and ZapA of Proteus mirabilis, using N-alpha mercaptoamide template-based inhibitor analogues.
PubMed:Enzymatic characterization of a serralysin-like metalloprotease from the entomopathogen bacterium, Xenorhabdus.
PubMed:A subset of metzincins and related genes constitutes a marker of human solid organ fibrosis.
PubMed:Proteolytic enzyme production by strains of the insect pathogen xenorhabdus and characterization of an early-log-phase-secreted protease as a potential virulence factor.
PubMed:Cloning, expression, and identification of a novel extracellular cold-adapted alkaline protease gene of the marine bacterium strain YS-80-122.
PubMed:Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site.
PubMed:Identification of natural target proteins indicates functions of a serralysin-type metalloprotease, PrtA, in anti-immune mechanisms.
PubMed:A novel serralysin metalloprotease from Deinococcus radiodurans.
PubMed:A novel secreted protease from Pseudomonas aeruginosa activates NF-kappaB through protease-activated receptors.
PubMed:Bioconversion of squid pen by Lactobacillus paracasei subsp paracasei TKU010 for the production of proteases and lettuce growth enhancing biofertilizers.
PubMed:Biochemical and genetic characterization of arazyme, an extracellular metalloprotease produced from Serratia proteamaculans HY-3.
PubMed:Characterization and role of a metalloprotease induced by chitin in Serratia sp. KCK.
PubMed:Cleavage site analysis of a serralysin-like protease, PrtA, from an insect pathogen Photorhabdus luminescens and development of a highly sensitive and specific substrate.
PubMed:Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2.
PubMed:Complex regulation of AprA metalloprotease in Pseudomonas fluorescens M114: evidence for the involvement of iron, the ECF sigma factor, PbrA and pseudobactin M114 siderophore.
PubMed:Contribution of a single-turn alpha-helix to the conformational stability and activity of the alkaline proteinase inhibitor of Pseudomonas aeruginosa.
PubMed:Proteus mirabilis ZapA metalloprotease degrades a broad spectrum of substrates, including antimicrobial peptides.
PubMed:In vitro and in vivo studies of the Yrp1 protease from Yersinia ruckeri and its role in protective immunity against enteric red mouth disease of salmonids.
PubMed:Self-assembly of proteins into designed networks.
PubMed:Alkaline proteinase inhibitor of Pseudomonas aeruginosa: a mutational and molecular dynamics study of the role of N-terminal residues in the inhibition of Pseudomonas alkaline proteinase.
PubMed:The Cu(II) acetate complex of the heteroscorpionate ligand (2-hydroxy-3-t-butyl-methylphenyl)bis(3,5-dimethylpyrazolyl)methane: a structural model for copper-substituted serralysin and astacin.
PubMed:Elastase-producing Pseudomonas aeruginosa degrade plasma proteins and extracellular products of human skin and fibroblasts, and inhibit fibroblast growth.
PubMed:Typing of Pseudomonas aeruginosa strains in Turkish cystic fibrosis patients.
PubMed:Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteases.
PubMed:Bacterial division: the fellowship of the ring.
PubMed:Isolation and analysis of a protease gene with an ABC transport system in the fish pathogen Yersinia ruckeri: insertional mutagenesis and involvement in virulence.
PubMed:Mechanistic studies of the astacin-like Serratia metalloendopeptidase serralysin: highly active (>2000%) Co(II) and Cu(II) derivatives for further corroboration of a "metallotriad" mechanism.
PubMed:Arylamidase activity of neutral proteinase from Saccharomonospora canescens. Comparison with other Zn-proteinases that exhibit the same activity.
PubMed:Differential proteinase expression by Pseudomonas aeruginosa derived from chronic leg ulcers.
PubMed:The conformations of polypeptide chains where the main-chain parts of successive residues are enantiomeric. Their occurrence in cation and anion-binding regions of proteins.
PubMed:Protease C of Erwinia chrysanthemi: the crystal structure and role of amino acids Y228 and E189.
PubMed:Crystal structure of a complex between Pseudomonas aeruginosa alkaline protease and its cognate inhibitor: inhibition by a zinc-NH2 coordinative bond.
PubMed:Pathogenesis of Proteus mirabilis urinary tract infection.
PubMed:Development of an operational substrate for ZapA, a metalloprotease secreted by the bacterium Proteus mirabilis.
PubMed:[Serralysin Zn-metalloproteinases--structure, function, secretion pathway, and pathogenicity].
PubMed:Use of a 49-peptide library for a qualitative and quantitative determination of pseudomonal serralysin specificity.
PubMed:Comparative cleavage sites within the reactive-site loop of native and oxidized alpha1-proteinase inhibitor by selected bacterial proteinases.
PubMed:Use of liquid chromatography-mass spectrometry coupling for monitoring the serralysin-catalyzed hydrolysis of a peptide library.
PubMed:Identification of a member of the serralysin family isolated from a psychrotrophic bacterium, Pseudomonas fluorescens 114.
PubMed:ZapA, the IgA-degrading metalloprotease of Proteus mirabilis, is a virulence factor expressed specifically in swarmer cells.
PubMed:Specificity of Pseudomonas aeruginosa serralysin revisited, using biologically active peptides as substrates.
PubMed:Quantitation and enzymatic activity of the alkaline protease from Pseudomonas aeruginosa in culture supernatants from clinical strains.
PubMed:Kinetic characterization of the serralysins: a divergent catalytic mechanism pertaining to astacin-type metalloproteases.
PubMed:Activation of human matrix metalloproteinases by various bacterial proteinases.
PubMed:Purification and characterization of an extracellular metalloprotease from Pseudomonas fluorescens.
PubMed:Differentiation of thermolysins and serralysins by monoclonal antibodies.
PubMed:X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.
PubMed:Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.
PubMed:Molecular analysis of a metalloprotease from Proteus mirabilis.
PubMed:Serralysin and related bacterial proteinases.
PubMed:Families of zinc metalloproteases.
proteolytic enzyme preparation used concomitantly with an antibiotic in osteoarticular infections.
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