sage
plant material derived from the dried, crushed leaves of the sage, salvia officinalis l., lamiaceae
 
Notes:
a genus in the mint family ( lamiaceae).
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Name: salvia officinalis l.
FDA internal no.: 977002-44-0 
Category: spices, other natural seasonings and flavorings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FEMA Number: 3000  sage
FDA Mainterm: SAGE (SALVIA OFFICINALIS L.)
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart B--Specific Food Labeling Requirements
Sec. 101.22 Foods; labeling of spices, flavorings, colorings and chemical preservatives.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.10 Spices and other natural seasonings and flavorings.
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium
 sage  
Odor Description:
at 100.00 %. 
sage
 sage  
Taste Description:
sage
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
skin protecting agents
tonic
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Suppliers:
American Natural & Organic Spices
Sage Whole, Ground or Rubbed, Available as 100% Certified Organic
Liberty Natural Products
SAGE LEAF POWDER ITALY
SupHerb Farms
Sage Medium
Fresh Frozen
SupHerb Farms
Sage Small
Fresh Frozen
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: spices, other natural seasonings and flavorings
Recommendation for sage usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -170.00000
beverages(nonalcoholic): -300.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -1500.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 salvia officinalis l.
Chemidplus: 0977002440
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References:
 salvia officinalis l.
Pubchem (sid): 135311475
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
FDA Listing of Food Additive Status: View
Wikipedia: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 sage
Search Trop  Picture
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Synonyms:
 plant material derived from the dried, crushed leaves of the sage, salvia officinalis l., lamiaceae
 sage
 sage bulgaria organic
 sage medium
 sage small
 sage whole, ground or rubbed, available as 100% certified organic
 salvia officinalis leaf
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Articles:
PubMed: Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: a randomized placebo. Controlled clinical trial.
PubMed: Kinetin applications alleviate salt stress and improve the antioxidant composition of leaf extracts in Salvia officinalis.
PubMed: Antihyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia: a randomized double-blind placebo-controlled clinical trial.
PubMed: Ecophysiological and antioxidant traits of Salvia officinalis under ozone stress.
PubMed: A simple and efficient DNA isolation method for Salvia officinalis.
PubMed: The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts.
PubMed: Seasonal variations of phenolic compounds and biological properties in sage (Salvia officinalis L.).
PubMed: Influence of ionic interactions on essential oil and phenolic diterpene composition of Dalmatian sage (Salvia officinalis L.).
PubMed: Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis).
PubMed: Laser ablation atmospheric pressure photoionization mass spectrometry imaging of phytochemicals from sage leaves.
PubMed: Antioxidant and inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant-induced lipid peroxidation in brain and liver in vitro.
PubMed: A direct liquid, non-equilibrium solid-phase micro-extraction application for analysing chemical variation of single peltate trichomes on leaves of Salvia officinalis.
PubMed: Catabolism of camphor in tissue cultures and leaf disks of common sage (Salvia officinalis).
PubMed: Relationship of Camphor Biosynthesis to Leaf Development in Sage (Salvia officinalis).
PubMed: Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery.
PubMed: [Quantitative change of terpenoids in germ-bud and leaf of Salvia officinalis L. under different conditions. 21. Contents of Salvia off. L].
PubMed: [Possibility of admittance of plant drugs Melissa officinalis, Mentha piperita and Salvia officinalis to the place of leaf drugs in the pharmacopeia].
PubMed: Application of non-linear models to predict inhibition effects of various plant hydrosols on Listeria monocytogenes inoculated on fresh-cut apples.
PubMed: Plant performance on Mediterranean green roofs: interaction of species-specific hydraulic strategies and substrate water relations.
PubMed: Dynamics of yield components and essential oil production in a commercial hybrid sage (Salvia officinalis x Salvia fruticosa cv. Newe Ya'ar no. 4).
PubMed: Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis).
PubMed: Metabolism of Monoterpenes : Metabolic Fate of (+)-Camphor in Sage (Salvia officinalis).
PubMed: Partial purification and characterization of two sesquiterpene cyclases from sage (Salvia officinalis) which catalyze the respective conversion of farnesyl pyrophosphate to humulene and caryophyllene.
PubMed: Metabolism of monoterpenes: demonstration of the hydroxylation of (+)-sabinene to (+)-cis-sabinol by an enzyme preparation from sage (Salvia officinalis) leaves.
PubMed: Isolation and structural elucidation of two new glycosides from sage (Salvia officinalis L.).
PubMed: Chemical composition of essential oil and leaf anatomy of Salvia bertolonii Vis. and Salvia pratensis L. (Sect. Plethiosphace, Lamiaceae).
PubMed: Antioxidant properties of biohybrids based on liposomes and sage silver nanoparticles.
PubMed: Specific leaf mass, fresh: dry weight ratio, sugar and protein contents in species of Lamiaceae from different light environments.
PubMed: Determination of water-soluble polyphenolic compounds in commercial herbal teas from Lamiaceae: peppermint, melissa, and sage.
PubMed: [Plant anatomical and phytochemical evaluation of Salvia species].
PubMed: Clomazone does not inhibit the conversion of isopentenyl pyrophosphate to geranyl, farnesyl, or geranylgeranyl pyrophosphate in vitro.
PubMed: Regulation of simultaneous synthesis of floral scent terpenoids by the 1,8-cineole synthase of Nicotiana suaveolens.
PubMed: Drought-induced changes in the redox state of alpha-tocopherol, ascorbate, and the diterpene carnosic acid in chloroplasts of Labiatae species differing in carnosic acid contents.
PubMed: Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor.
PubMed: Biosynthesis of monoterpenes: inhibition of (+)-pinene and (-)-pinene cyclases by thia and aza analogs of the 4R- and 4S-alpha-terpinyl carbocation.
PubMed: Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene.
PubMed: Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-bornyl pyrophosphate.
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