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gynostemma pentaphyllum extract
extract of the whole plant gynostemma pentaphyllum, cucurbitaceae

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Category:astringent, skin conditioning
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: astringents
skin conditioning
AuNutra® Industries
Gynostemma P.E
Lipotec USA
Actigen® O2
O'Laughlin Industries
GYMNOSTEMMA, Jiao Gu Lan Extract
Qingdao Dacon Trading
Gynostemma Pentaphyllum Extract
Xi'an Greena Biotech
Gynostemma Extract
Odor: characteristic
Use: Gynostemma, gourd plants, herbaceous perennial vine. There are 13 species worldwide are known to pentaphyllum.In China,it also called“South Ginseng”or “Miracle Leaf”.Gynostemma is rich in gypenosides,polysaccharide,amino acids,flavones,multivitamin and other active substance.It is traditionally used to help support and maintain normal healthy respiratory, cardiovascular, digestive and liver functions.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
astringent, skin conditioning
Recommendation for gynostemma pentaphyllum extract usage levels up to:
 not for fragrance use.
Recommendation for gynostemma pentaphyllum extract flavor usage levels up to:
 not for flavor use.
Safety References:
None found
None found
Other Information:
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 gynostemma pentaphyllum
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 extract of the whole plant gynostemma pentaphyllum, cucurbitaceae
twisting-vine orchid extract
 vitis pentaphylla extract


PubMed:Metabolic profiling of Gynostemma pentaphyllum extract in rat serum, urine and faeces after oral administration.
PubMed:Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats.
PubMed:Determination by UPLC-MS of four dammarane-type saponins from heat-processed Gynostemma pentaphyllum.
PubMed:Gypenoside attenuates hepatic ischemia/reperfusion injury in mice via anti-oxidative and anti-apoptotic bioactivities.
PubMed:Protective effects of Gynostemma pentaphyllum polysaccharides on PC12 cells impaired by MPP(+).
PubMed:Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice.
PubMed:Anti-cancer effect and the underlying mechanisms of gypenosides on human colorectal cancer SW-480 cells.
PubMed:Effects of gypenosides on anxiety disorders in MPTP-lesioned mouse model of Parkinson's disease.
PubMed:The Effect of Gynostemma pentaphyllum Extract on Mouse Dermal Fibroblasts.
PubMed:Attenuation of Aβ25-35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways.
PubMed:Characterization of a novel alkali-soluble heteropolysaccharide from tetraploid Gynostemma pentaphyllum Makino and its potential anti-inflammatory and antioxidant properties.
PubMed:[Molecular diversity of arbuscular mycorrhizal fungi in wild and cultured Gynostemma pentaphyllum roots in Xishuangbanna, Southwest China].
PubMed:Cytotoxic activity of gypenosides and gynogenin against non-small cell lung carcinoma A549 cells.
PubMed:Two novel anti-inflammatory 21-nordammarane saponins from tetraploid Jiaogulan ( Gynostemma pentaphyllum ).
PubMed:Metabonomics study of the therapeutic mechanism of Gynostemma pentaphyllum and atorvastatin for hyperlipidemia in rats.
PubMed:Arthrobacter gyeryongensis sp. nov., isolated from soil of a Gynostemma pentaphyllum field.
PubMed:Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities.
PubMed:Herbal medicines for fatty liver diseases.
PubMed:Antiproliferation and anti-migration induced by gypenosides in human colon cancer SW620 and esophageal cancer Eca-109 cells.
PubMed:Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial.
PubMed:Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino.
PubMed:Characterization of a novel polysaccharide from tetraploid Gynostemma pentaphyllum makino.
PubMed:Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress.
PubMed:Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells.
PubMed:[Experimental research on prevention and treatment of fatty liver rats with Abrus cantoniensis].
PubMed:Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients.
PubMed:Characterization of a heteropolysaccharide isolated from diploid Gynostemma pentaphyllum Makino.
PubMed:Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery.
PubMed:Ombuin-3-O-β-D-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors α and δ/β.
PubMed:Chemical Composition of Three Polysaccharides From Gynostemma pentaphyllum and Their Antioxidant Activity in Skeletal Muscle of Exercised Mice.
PubMed:Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.
PubMed:Chemical differentiation of two taste variants of Gynostemma pentaphyllum by using UPLC-Q-TOF-MS and HPLC-ELSD.
PubMed:Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients.
PubMed:Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells.
PubMed:Two new triterpene saponins from Gynostemma pentaphyllum.
PubMed:Chemical composition of three polysaccharides from Gynostemma pentaphyllum and their antioxidant activity in skeletal muscle of exercised mice.
PubMed:Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats.
PubMed:Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis.
PubMed:Dammarane glycosides from the root of Machilus yaoshansis.
PubMed:Isolation and antitumor activities of acidic polysaccharide from Gynostemma pentaphyllum Makino.
PubMed:Restoration of electric footshock-induced immunosuppression in mice by Gynostemma pentaphyllum components.
PubMed:Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide.
PubMed:[Determination of arsenic, mercury and selenium in Gynostemma pentaphyllum and rhizospheric soil samples collected from different regions by hydride generation atomic fluorescence spectrometry].
PubMed:Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase.
PubMed:Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract--stimulation of anti-oxidative enzyme expression.
PubMed:Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract.
PubMed:Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum.
PubMed:New dammarane-type glycosides from the roots of Gynostemma pentaphyllum.
PubMed:[Study of xiaozhang recipe combined with lamivudine in treatment of 84 chronic viral hepatitis B patients with compensated liver cirrhosis].
PubMed:A new triterpenoid saponin from Gynostemma pentaphyllum.
PubMed:New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum.
PubMed:Antiproliferation effect and apoptosis mechanism of prostate cancer cell PC-3 by flavonoids and saponins prepared from Gynostemma pentaphyllum.
PubMed:Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation.
PubMed:Transcriptome profiling and insilico analysis of Gynostemma pentaphyllum using a next generation sequencer.
PubMed:Antimicrobial activity of Gynostemma pentaphyllum extracts against fungi producing aflatoxin and fumonisin and bacteria causing diarrheal disease.
PubMed:Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways.
PubMed:Herbal extract of gynostemma pentaphyllum decreases hepatic glucose output in type 2 diabetic goto-kakizaki rats.
PubMed:Microsatellite markers in the traditional Chinese medicinal herb Gynostemma pentaphyllum (Cucurbitaceae).
PubMed:Dammarane-type saponins from Gynostemma pentaphyllum.
PubMed:Chromatographic fingerprint analysis and rutin and quercetin compositions in the leaf and whole-plant samples of di- and tetraploid Gynostemma pentaphyllum.
PubMed:Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice.
PubMed:Triterpenoid saponins from Gynostemma pentaphyllum.
PubMed:Taxonomic significance of trichomes micromorphology in cucurbits.
PubMed:Preparative chromatography of flavonoids and saponins in Gynostemma pentaphyllum and their antiproliferation effect on hepatoma cell.
PubMed:Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome.
PubMed:Preparation of carotenoids and chlorophylls from Gynostemma pentaphyllum (Thunb.) Makino and their antiproliferation effect on hepatoma cell.
PubMed:Chemical composition of five commercial Gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties.
PubMed:An experimental study on the antileukemia effects of gypenosides in vitro and in vivo.
PubMed:Gypenosides protects dopaminergic neurons in primary culture against MPP(+)-induced oxidative injury.
PubMed:Long-term oral administration of Gynostemma pentaphyllum extract attenuates airway inflammation and Th2 cell activities in ovalbumin-sensitized mice.
PubMed:Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.
PubMed:Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways.
PubMed:Dammarane saponins from Gynostemma pentaphyllum.
PubMed:Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.
PubMed:Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
PubMed:Dammarane-type saponins from Gynostemma pentaphyllum.
PubMed:Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients.
PubMed:Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation.
PubMed:Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract.
PubMed:Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells.
PubMed:Gypenoside LXXIV ameliorates scopolamine-induced learning deficit in mice.
PubMed:Gynostemosides A-E, megastigmane glycosides from Gynostemma pentaphyllum.
PubMed:The inhibitory effect of Gynostemma pentaphyllum on MCP-1 and type I procollagen expression in rat hepatic stellate cells.
PubMed:Screening of the hypoglycemic effect of eight Vietnamese herbal drugs.
PubMed:[Fingerprints identification of Gynostemma pentaphyllum by RAPD and cloning and analysis of its specific DNA fragment].
PubMed:Effect of Gynostemma Pentaphyllum polysaccharide on boar spermatozoa quality following freezing-thawing.
PubMed:Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extract.
PubMed:Protein tyrosine phosphatase 1B inhibitory by dammaranes from Vietnamese Giao-Co-Lam tea.
PubMed:Polyploid origins in Gynostemma pentaphyllum (Cucurbitaceae) inferred from multiple gene sequences.
PubMed:Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db mice.
PubMed:Immunomodulatory effects of cadmium and Gynostemma pentaphyllum herbal tea on rat splenocyte proliferation.
PubMed:Determination of flavonoids and saponins in Gynostemma pentaphyllum (Thunb.) Makino by liquid chromatography-mass spectrometry.
PubMed:Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells.
PubMed:Isolation and characterization of immunostimulatory polysaccharide from an herb tea, Gynostemma pentaphyllum Makino.
PubMed:Determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino by liquid chromatography-mass spectrometry.
PubMed:Gynostemma pentaphyllum decreases allergic reactions in a murine asthmatic model.
PubMed:Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9.
PubMed:Gypenosides induced G0/G1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and -9 in human lung cancer A-549 cells.
PubMed:[The effect of Gynostemma pentaphyllum (GP) on plasma lipoprotein metabolism and lipoperoxidation lipoprotein in the experimental hyperglycemia rats].
PubMed:The molecular mechanism of gypenosides-induced G1 growth arrest of rat hepatic stellate cells.
PubMed:Method development for gypenosides fingerprint by high performance liquid chromatography with diode-array detection and the addition of internal standard.
PubMed:[Influence of FPS on the expression of LDL-R mRNA in the liver tissues of hyperlipidemic rats].
PubMed:[Studies on the HPLC fingerprint spectrum of flavonoids in Gynostemma pentaphyllum].
PubMed:Specific reversal of multidrug resistance to colchicine in CEM/VLB(100) cells by Gynostemma pentaphyllum extract.
PubMed:Determination of the three-dimensional structure of Gynoside A in solution using NMR and molecular modeling.
PubMed:Gypenosides inhibited N-acetylation of 2-aminofluorene, N-acetyltransferase gene expression and DNA adduct formation in human cervix epithelioid carcinoma cells (HeLa).
PubMed:Extract of Gynostemma pentaphyllum enhanced the production of antibodies and cytokines in mice.
PubMed:Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells.
PubMed:Phytopreventative effects of Gynostemma pentaphyllum against acute Indomethacin-induced gastrointestinal and renal toxicity in rats.
PubMed:The possible mechanisms by which phanoside stimulates insulin secretion from rat islets.
PubMed:Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat.
PubMed:Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3.
PubMed:Nine new dammarane saponins from Gynostemma pentaphyllum.
PubMed:Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.
PubMed:[Simultaneous determination of total flavone and total saponin in Gynostemma pentaphyllum by signal multiplier spectrophotometry].
PubMed:[The extraction, purification and assaying of Gynostemma pentaphyllum polysaccharides].
PubMed:Determination of trace elements in herbal tea products and their infusions consumed in Thailand.
PubMed:Management of SAH with traditional Chinese medicine in China.
PubMed:The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.
PubMed:Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway.
PubMed:Phytopreventative anti-hyperlipidemic effects of gynostemma pentaphyllum in rats.
PubMed:Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice.
PubMed:Three dammarane-type saponins from Gynostemma pentaphyllum.
PubMed:Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino.
PubMed:Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract.
PubMed:Hairy root cultures of Gynostemma pentaphyllum (Thunb.) Makino: a promising approach for the production of gypenosides as an alternative of ginseng saponins.
PubMed:A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum.
PubMed:Bronchodilatory effects of the aqueous extract of Gynostemma pentaphyllum and gypenosides III and VIII in anaesthetized guinea-pigs.
PubMed:[Histochemical localization of ginsenosides in Gynostemma pentaphyllum and the content changes of total gypenosides].
PubMed:[Study on spectral properties of Chinese herbal medicines additives in cosmetic].
PubMed:[The analysis of Gynostemma pentaphyllum (Thunb) Makino for Chinese crude drug by FTIR and FT-Raman].
PubMed:[Photosynthetic characteristics of Gynostemma pentaphyllum under shade].
PubMed:[Composition analysis and dominance test of three kinds of raw variety of Gynostemma pentaphyllum].
PubMed:Novel dammarane-type glycosides from Gynostemma pentaphyllum.
PubMed:[Studies on sex identification and variation of endogenous hormones in female and male plants of Gynostemma pentaphyllum].
PubMed:Chronic toxicity of Gynostemma pentaphyllum.
PubMed:[Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism].
PubMed:The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino.
PubMed:Five new Ocotillone-type saponins from Gynostemma pentaphyllum.
PubMed:A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum.
PubMed:Dammarane-type glycosides from Gynostemma pentaphyllum.
PubMed:[Determination of six nutritional elements in Chinese herbal medicines by graphite furnace atomic absorption spectrometry].
PubMed:[Light environment characteristics of forest gap in deciduous broad-leaved forest and its effects on growth features of Gynostemma pentaphyllum in Jianghuai watershed].
PubMed:Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression.
PubMed:[Comparison of total saponin content in three wild species of Gynostemma on Mount Emei].
PubMed:[Scavenging effects of Astragalus and Gynostemma pentaphyllum with its product on O2-. and .OH].
PubMed:Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells.
PubMed:[Dynamic features of some biochemical constituents in Gynostemma pentaphyllum under different environments].
PubMed:Inhibitory effects of gynostemma pentaphyllum on the UV induction of bacteriophage lambda in lysogenic Escherichia coli.
PubMed:Effect of gynostemma pentaphyllum mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study.
PubMed:Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats.
PubMed:Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum.
PubMed:Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells.
PubMed:The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum.
PubMed:Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species.
PubMed:[Determination on the glycosyl sequence of gypenoside A by TLC-FABMS].
PubMed:[The study of influencing cellular dynamics of gynostemma pentaphyllum on golden hamster cheek pouch premalignancy]
PubMed:New triterpenoid saponins from Gynostemma pentaphyllum.
PubMed:[The effect of Gynostemma pentaphyllum mak (GP) on carcinogenesis of the golden hamster cheek pouch induced by DMBA].
PubMed:[Observation of the effectiveness of compound Gynostemma Pentaphyllum Mak in golden hamster cheek pouch's premalignancy]
PubMed:Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice.
PubMed:[A preliminary observation of preventive and blocking effect of Gynostemma pentaphyllum (Thunb) Makino on esophageal cancer in rats].
PubMed:New dammarane-type glycosides from Gynostemma pentaphyllum.
PubMed:[Effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell].
PubMed:Protoplast culture and plant regeneration from the suspension cells of Gynostemma pentaphyllum (Thumb) Mak.
PubMed:[Systematic concept and development model for the production base of Gynostemma pentaphyllum (Thunb.) Madino].
PubMed:[Agronomic standardization of Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:[Intercropping techniques for Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:[Semi-culture techniques for Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:[Antithrombotic effect of Gynostemma pentaphyllum].
PubMed:Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
PubMed:Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes.
PubMed:[Introduction and cultivation of Gynostemma pentaphyllum Mark. in Beijing].
PubMed:Effects of gynostemma pentaphyllum makino on the immunological function of cancer patients.
PubMed:[Spectrophotometric determination of micro-amounts of zinc in Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:[Isolation and identification of flavonoids and organic acids from Gynostemma pentaphyllum Makino].
PubMed:[Clonal propagation of Gynostemma pentaphyllum (Thumb.) Makino in test tubes].
PubMed:[A comparative identification of four Gynostemma spp. herbs and their various species from Guangxi].
PubMed:[Rapid propagation of Gynostemma pentaphyllum Makino via tissue culture].
PubMed:A new platelet aggregation factor from Gynostemma pentaphyllum Makino.
None found
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