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sanguinaria canadensis rhizome/root extract
extract of the rhizomes and roots of the blood root, sanguinaria canadensis l., papaveraceae

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Name:sanguinaria canadensis rhizome/root extract
CAS Number: 84929-48-6
ECHA EC Number:284-532-0
FDA UNII: Search
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: cleansing agents
refreshing agents
skin conditioning
BOC Sciences
For experimental / research use only.
Sanguinaria canadensis, ext. 95%
blood root extract
Grau Aromatics
SRS Aromatics
Vege Tech
sanguinaria extract
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for sanguinaria canadensis rhizome/root extract usage levels up to:
 not for fragrance use.
Recommendation for sanguinaria canadensis rhizome/root extract flavor usage levels up to:
 not for flavor use.
Safety References:
Daily Med:search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
sanguinaria canadensis rhizome/root extract
 sanguinaria canadensis rhizome/root extract
Pubchem (sid):135326333
Other Information:
Export Tariff Code:1302.19.0000
Potential Blenders and core components note
None Found
Potential Uses:
 cleansing agents
 refreshing agents
 skin conditioning
Occurrence (nature, food, other):note
 sanguinaria canadensis
Search Trop Picture
 blood rhizome/root extract
 bloodroot rhizome/root extract
 extract of the rhizomes and roots of the blood root, sanguinaria canadensis l., papaveraceae
red-puccoon rhizome/root extract
 sanguinaria australis rhizome/root extract
 sanguinaria canadensis var. rotundifolia rhizome/root extract
 sanguinaria dilleniana rhizome/root extract
 sanguinaria rhizome/root extract


PubMed:Bloodroot associated eschar.
PubMed:In vitro screening of forty medicinal plant extracts from the United States Northern Great Plains for anthelmintic activity against Haemonchus contortus.
PubMed:A review of topical corrosive black salve.
PubMed:Hybrid poplar plantations are suitable habitat for reintroduced forest herbs with conservation status.
PubMed:Signals can trump rewards in attracting seed-dispersing ants.
PubMed:Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
PubMed:Efficacy of a non-hormonal treatment, BRN-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial.
PubMed:Rise and fall of oral health products with Canadian bloodroot extract.
PubMed:Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway.
PubMed:Consequences of intratumoral injection of a herbal preparation containing blood root (Sanguinaria canadensis) extract in two dogs.
PubMed:The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus.
PubMed:An Internet misadventure: bloodroot salve toxicity.
PubMed:Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model.
PubMed:Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3.
PubMed:Human blood mononuclear cell in vitro cytokine response before and after two different strenuous exercise bouts in the presence of bloodroot and Echinacea extracts.
PubMed:In vitro screening for the tumoricidal properties of international medicinal herbs.
PubMed:Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation.
PubMed:Histopathologic findings and diagnostic difficulties posed with use of escharotic agents for treatment of skin lesions: a case report and review of the literature.
PubMed:Treating hot flushes in menopausal women with homeopathic treatment--results of an observational study.
PubMed:Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL.
PubMed:Effects of aqueous extracts from five species of the family Papaveraceae on selected aquatic organisms.
PubMed:Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.
PubMed:Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix.
PubMed:Sanguinarine inhibits VEGF-induced Akt phosphorylation.
PubMed:HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae.
PubMed:The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis.
PubMed:Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).
PubMed:Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization.
PubMed:Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production.
PubMed:Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
PubMed:Suppression of angiogenesis by the plant alkaloid, sanguinarine.
PubMed:Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability.
PubMed:Forest edges and fire ants alter the seed shadow of an ant-dispersed plant.
PubMed:Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes.
PubMed:In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.
PubMed:Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer.
PubMed:Capillary electrophoresis of phytochemical substances.
PubMed:The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.
PubMed:Environmental and genotypic influences on isoquinoline alkaloid content in Sanguinaria canadensis.
PubMed:Elevational trends in defense chemistry, vegetation, and reproduction in Sanguinaria canadensis.
PubMed:Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps.
PubMed:Involvement of protein kinase and G proteins in the signal transduction of benzophenanthridine alkaloid biosynthesis.
PubMed:Immunoblot analyses of the elicited Sanguinaria canadensis enzyme, dihydrobenzophenanthridine oxidase: evidence for resolution from a polyphenol oxidase isozyme.
PubMed:Elicitation of dihydrobenzophenanthridine oxidase in Sanguinaria canadensis cell cultures.
PubMed:Quercetin-induced benzophenanthridine alkaloid production in suspension cell cultures of Sanguinaria canadensis.
PubMed:Isolation and Characterization of S-Adenosyl-L-Methionine:Tetrahydroberberine-cis-N-Methyltransferase from Suspension Cultures of Sanguinaria canadensis L.
PubMed:Differential enhancement of benzophenanthridine alkaloid content in cell suspension cultures of Sanguinaria canadensis under conditions of combined hormonal deprivation and fungal elicitation.
PubMed:Purification and characterization of dihydrobenzophenanthridine oxidase from elicited Sanguinaria canadensis cell cultures.
PubMed:Growth characteristics of Sanguinaria canadensis L. cell suspensions and immobilized cultures for production of benzophenanthridine alkaloids.
PubMed:Characterization of Sanguinaria canadensis L. fluid extract by FAB mass spectrometry.
PubMed:The history, chemistry and pharmacokinetics of Sanguinaria extract.
PubMed:Antimicrobial action of sanguinarine.
PubMed:Short-term toxicity studies of sanguinarine and of two alkaloid extracts of Sanguinaria canadensis L.
PubMed:Plant tyrosine decarboxylase can be strongly inhibited by L-α-aminooxy-β-phenylpropionate.
PubMed:Sanguinarine: a positive inotropic alkaloid which inhibits cardiac Na+,K+-ATPase.
PubMed:Biological and phytochemical evaluation of plants. 8. Isolation of a new alkaloid from Sanguinaria canadensis.
PubMed:[Separation of sanguinarine and chelerythrine and additional plant bases of Sanguinaria canadensis].
None found
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