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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 45.29 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 2,3-dehydrosilybin usage levels up to: | | | not for fragrance use.
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| Recommendation for 2,3-dehydrosilybin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :10696082 |
| National Institute of Allergy and Infectious Diseases:Data |
| 3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one |
References:
| | 3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10696082 |
| Pubchem (cas): | 25166-14-7 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3,5,7- | trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one |
Articles:
| PubMed:Metabolism of flavonolignans in human hepatocytes. |
| PubMed:5- or/and 20-O-alkyl-2,3-dehydrosilybins: Synthesis and biological profiles on prostate cancer cell models. |
| PubMed:Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral Study. |
| PubMed:Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry. |
| PubMed:Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells. |
| PubMed:Galloylation of polyphenols alters their biological activity. |
| PubMed:2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. |
| PubMed:Silychristin: Skeletal Alterations and Biological Activities. |
| PubMed:Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells. |
| PubMed:Phototoxic potential of silymarin and its bioactive components. |
| PubMed:Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart. |
| PubMed:Silybin and 2,3-Dehydrosilybin Flavonolignans as Free Radical Scavengers. |
| PubMed:Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress. |
| PubMed:Induction of apoptosis by 2,3-dehydrosilybin via a caspase-dependent pathway in human HeLa cells. |
| PubMed:Chemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers. |
| PubMed:Media effects on the mechanism of antioxidant action of silybin and 2,3-dehydrosilybin: role of the enol group. |
| PubMed:A rapid and simple chromatographic separation of diastereomers of silibinin and their oxidation to produce 2,3-dehydrosilybin enantiomers in an optically pure form. |
| PubMed:Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship. |
| PubMed:Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats. |
| PubMed:Bioconversion of silybin to phase I and II microbial metabolites with retained antioxidant activity. |
| PubMed:Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II). |
| PubMed:New C-23 modified of silybin and 2,3-dehydrosilybin: synthesis and preliminary evaluation of antioxidant properties. |
| PubMed:Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger. |
| PubMed:Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives. |
| PubMed:Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity--role of individual hydroxyl groups. |
| PubMed:2,3-dehydrosilybin is a better DNA topoisomerase I inhibitor than its parental silybin. |
| PubMed:Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin. |
| PubMed:Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: a joint experimental and theoretical study. |
| PubMed:Potent direct or TNF-alpha-promoted anticancer effects of 2,3-dehydrosilybin: comparison study with silybin. |
| PubMed:Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage to HaCaT keratinocytes. |
| PubMed:New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity. |
| PubMed:Oxidised derivatives of silybin and their antiradical and antioxidant activity. |
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