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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 7.712e-005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for annonacin A usage levels up to: | | | not for fragrance use.
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| Recommendation for annonacin A flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-methyl-4-[2,8,13-trihydroxy-13-[5-(1-hydroxytridecyl)oxolan-2-yl]tridecyl]-2H-furan-5-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 179866 |
| Pubchem (cas): | 130853-76-8 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | methyl-4-[2,8,13-trihydroxy-13-[5-(1-hydroxytridecyl)oxolan-2-yl]tridecyl]-2H-furan-5-one |
Articles:
| PubMed:Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. |
| PubMed:The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway. |
| PubMed:Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I. |
| PubMed:Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. |
| PubMed:Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. |
| PubMed:Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. |
| PubMed:Murihexol, a linear acetogenin from Annona muricata. |
| PubMed:Cytotoxicity and antileishmanial activity of Annona muricata pericarp. |
| PubMed:The localisations in liposomal membranes of the tetrahydrofuran ring moieties of the annonaceous acetogenins, annonacin and sylvaticin, as determined by 1H NMR spectroscopy. |
| PubMed:Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea. |
| PubMed:In vitro antitumor activities of new synthetic bistetrahydrofuran derivatives as analogs of Annonaceous acetogenins. |
| PubMed:[Studies on the chemical constituents of Annona muricata]. |
| PubMed:Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba. |
| PubMed:Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata. |
| PubMed:Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata. |
| PubMed:Biologically active acetogenins from stem bark of Asimina triloba. |
| PubMed:[Annonacins and Annonastatin from Annona squamosa]. |
| PubMed:Annonacin, a novel, biologically active polyketide from Annona densicoma. |
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3D/inchi