bullatacin, 123123-32-0

Articles:

PubMed:The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis.

PubMed:[Structure activity relationship of annonaceous acetogenins against multidrug resistant human lung cancer cell line A549/Taxol in vitro].

PubMed:Reduction of Synthetic Ubiquinone QT Catalyzed by Bovine Mitochondrial Complex I Is Decoupled from Proton Translocation.

PubMed:Acetogenins as Potential Anticancer Agents.

PubMed:Amilorides bind to the quinone binding pocket of bovine mitochondrial complex I.

PubMed:Pinpoint chemical modification of Asp160 in the 49 kDa subunit of bovine mitochondrial complex I via a combination of ligand-directed tosyl chemistry and click chemistry.

PubMed:Site-specific chemical labeling of mitochondrial respiratory complex I through ligand-directed tosylate chemistry.

PubMed:Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins.

PubMed:Antitumor activity and toxicity relationship of annonaceous acetogenins.

PubMed:Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds.

PubMed:Determination of bullatacin in rat plasma by liquid chromatography-mass spectrometry.

PubMed:Forskolin and derivatives as tools for studying the role of cAMP.

PubMed:Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa.

PubMed:Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase.

PubMed:In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis: trematocidal plant alcoholic extracts.

PubMed:The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I.

PubMed:Susceptibility of complete bacteria and spheroplasts of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi to rolliniastatin-2.

PubMed:Exploring the binding site of delta(lac)-acetogenin in bovine heart mitochondrial NADH-ubiquinone oxidoreductase.

PubMed:The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor.

PubMed:Identification of annonaceous acetogenins in the ripe fruit of the North American pawpaw ( Asimina triloba ).

PubMed:Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway.

PubMed:Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species.

PubMed:Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia.

PubMed:Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.

PubMed:Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I.

PubMed:Advances in Lewis acid controlled carbon-carbon bond-forming reactions enable a concise and convergent total synthesis of bullatacin.

PubMed:An outside-in approach to adjacent bistetrahydrofuran annonaceous acetogenins with C2 core symmetry. Total synthesis of asimicin and a C32 analogue.

PubMed:Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I.

PubMed:Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane.

PubMed:Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes.

PubMed:Stereoselective syntheses of rolliniastatin 1, rollimembrin, and membranacin.

PubMed:Synthesis and inhibition mechanism of Delta lac-acetogenins, a novel type of inhibitor of bovine heart mitochondrial complex I.

PubMed:Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I.

PubMed:In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I.

PubMed:New adjacent Bis-tetrahydrofuran Annonaceous acetogenins from Annona muricata.

PubMed:A modular synthesis of annonaceous acetogenins.

PubMed:[Inhibition of oxygen consumption by annonaceous acetogenins in liver cell respiration and their structure-activity relationship].

PubMed:Selective action of acetogenin mitochondrial complex I inhibitors.

PubMed:Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells.

PubMed:[Antitumor effect of anuoning].

PubMed:[Classification and NMR characteristics of the gamma-lactone and THF rings of antitumor bioactive Annonaceous acetogenins].

PubMed:Mimicry of annonaceous acetogenins: enantioselective synthesis of a (4R)-hydroxy analogue having potent antitumor activity.

PubMed:Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction.

PubMed:Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.

PubMed:Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I.

PubMed:Total synthesis of asimicin and bullatacin.

PubMed:Circumvention of tumor multidrug resistance by a new annonaceous acetogenin: atemoyacin-B.

PubMed:Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics.

PubMed:New annonaceous acetogenins from Rollinia mucosa.

PubMed:Tryptamine derived amides and acetogenins from the seeds of Rollinia mucosa.

PubMed:Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins.

PubMed:Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells.

PubMed:NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.

PubMed:Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy.

PubMed:Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).

PubMed:Annonaceous acetogenins as natural pesticides: potent toxicity against insecticide-susceptible and -resistant German cockroaches (Dictyoptera: Blattellidae).

PubMed:Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea.

PubMed:Acetogenins from seeds of Annona reticulata.

PubMed:Membrane conformations and their relation to cytotoxicity of asimicin and its analogues.

PubMed:Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I).

PubMed:Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent.

PubMed:Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.

PubMed:Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype.

PubMed:The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells.

PubMed:Measurement of the membrane potential generated by complex I in submitochondrial particles.

PubMed:Genetic evidence for the existence of two quinone related inhibitor binding sites in NADH-CoQ reductase.

PubMed:Longimicins A-D: novel bioactive acetogenins from Asimina longifolia (annonaceae) and structure-activity relationships of asimicin type of annonaceous acetogenins.

PubMed:Squamotacin: an annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3).

PubMed:SARs of annonaceous acetogenins in rat liver mitochondria.

PubMed:The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba.

PubMed:Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes.

PubMed:Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).

PubMed:Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba.

PubMed:Bullatacin--in vivo and in vitro experience in an ovarian cancer model.

PubMed:Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin.

PubMed:Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba.

PubMed:Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa.

PubMed:Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata.

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