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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.0003012 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for cyclolinopeptide A usage levels up to: | | | not for fragrance use.
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| Recommendation for cyclolinopeptide A flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :182122 |
| National Institute of Allergy and Infectious Diseases:Data |
| cyclo[L-isoleucyl-L-leucyl-L-leucyl-DL-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-valyl] |
| Chemidplus:0033302555 |
References:
| | cyclo[L-isoleucyl-L-leucyl-L-leucyl-DL-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-valyl] |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 182122 |
| Pubchem (cas): | 33302-55-5 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cyclo[L-isoleucyl-L-leucyl-L-leucyl-DL-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-valyl] |
Articles:
| PubMed:Synthesis and biological activity of cyclolinopeptide A analogues modified with γ4-bis(homo-phenylalanine). |
| PubMed:Synthesis and biological activity of cyclolinopeptide A analogues modified with γ(3)-bis(homophenylalanine). |
| PubMed:The structure of cyclolinopeptide A in chloroform refined by RDC measurements. |
| PubMed:Effect of cyclolinopeptides on the oxidative stability of flaxseed oil. |
| PubMed:Identification and quantification of cyclolinopeptides in five flaxseed cultivars. |
| PubMed:Cyclolinopeptide derivatives modify methotrexate-induced suppression of the humoral immune response in mice. |
| PubMed:Biomolecular interaction study of Cyclolinopeptide A with human serum albumin. |
| PubMed:Synthesis and immunosuppressive activity of cyclolinopeptide A analogues containing homophenylalanine. |
| PubMed:Synthesis, conformational analysis and immunological activity of beta3Phe-substituted Cyclolinopeptide A analogues. |
| PubMed:Synthesis and immunosuppressive activity of new cyclolinopeptide A analogs modified with beta-prolines. |
| PubMed:Cyclopeptides of Linum usitatissimum. |
| PubMed:Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins. |
| PubMed:Cyclolinopeptide A: inhibitor, immunosuppressor or other? |
| PubMed:Analogues of cyclolinopeptide A containing alpha-hydroxymethyl amino acid residues. |
| PubMed:Synthesis, conformation, and immunosuppressive activity of CLX and its analogues. |
| PubMed:Tetrazole analogues of cyclolinopeptide A: synthesis, conformation, and biology. |
| PubMed:Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides. |
| PubMed:Antimalarial activity of cyclolinopeptide A and its analogues. |
| PubMed:Cyclolinopeptide: a novel immunosuppressive agent with potential anti-lipemic activity. |
| PubMed:Solid state structural analysis of the cyclooctapeptide cyclo- (Pro1-Pro-Phe-Phe-Ac6c-Ile-D-Ala-Val8). |
| PubMed:Cyclolinopeptides and their analogs--a new family of peptide immunosuppressants affecting the calcineurin system. |
| PubMed:Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide A. |
| PubMed:Cyclolinopeptide A (CLA) mediates its immunosuppressive activity through cyclophilin-dependent calcineurin inactivation. |
| PubMed:Binding proteins for cyclic and linear oligopeptides in plasma membranes and the cytosol of rat hepatocytes. |
| PubMed:Sulfonated analogues of cyclolinopeptide A. Synthesis, immunosuppressive activity and CD studies. |
| PubMed:Autoradiographic distribution of bombesin/gastrin-releasing peptide receptors in fetal cortex transplants. |
| PubMed:Effects of cyclolinopeptide A on T lymphocyte activation and peptidyl prolyl isomerase activity. |
| PubMed:Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes. |
| PubMed:Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide A. |
| PubMed:Conformational behaviour of a cyclolinopeptide A analogue: two-dimensional NMR study of cyclo(Pro1-Pro-Phe-Phe-Ac6c-Ile-ala-Val8). |
| PubMed:Specific interaction between cyclophilin and cyclic peptides. |
| PubMed:[Aib5,6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture. |
| PubMed:Does the edge-to-face interaction between aromatic rings occur in cyclolinopeptide A analogues? |
| PubMed:Bioactive peptides: solid state, solution and molecular dynamics studies of a cyclolinopeptide A-related cystinyl cyclopentapeptide. |
| PubMed:Synthesis and biological studies on analogs of cyclolinopeptide A with a shortened peptide chain. |
| PubMed:Immunosuppressive activity in the series of cycloamanide peptides from mushrooms. |
| PubMed:Immunosuppressive activity of alanine analogs of cyclolinopeptide A. |
| PubMed:Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A. |
| PubMed:Immunosuppressive activity of antamanide and some of its analogues. |
| PubMed:Molecular dynamics simulation in vacuo and in solution of [Aib5,6-D-Ala8] cyclolinopeptide A: a conformational and comparative study. |
| PubMed:Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A. |
| PubMed:Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A. |
| PubMed:Immunosuppressive activity of cyclolinopeptide A. |
| PubMed:Molecular dynamics simulation in vacuo and in solution of cyclolinopeptide A: a conformational study. |
| PubMed:Ion binding of cyclolinopeptide A: an NMR and CD conformational study. |
| PubMed:Conformational study of cyclolinopeptide A. A distance geometry and molecular dynamics approach. |
| PubMed:Conformation of cyclolinopeptide dihydrate: an antamanide analogue. |
| PubMed:Conformational analysis of cyclolinopeptide A, a cyclic nonapeptide: nuclear Overhauser effect and energy minimization studies. |
| PubMed:Comparison of the conformations of cyclolinopeptide A in the solid state and in solution. |
| PubMed:Ala analogues of the cyclolinopeptide A. |
| PubMed:Conformations of bioactive peptides: cyclolinopeptide A. |
| PubMed:Approximate treatment of the conformational characteristics of a cyclic nonapeptide, cyclolinopeptide a. |
| PubMed:Conformation of cyclolinopeptide a observed by nuclear magnetic resonance spectroscopy. |
| PubMed:Conformation of cyclolinopeptide a observed by circular dichroism. |
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3D/inchi