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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.05579 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for arjunolic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for arjunolic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :73641 |
| National Institute of Allergy and Infectious Diseases:Data |
| (4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
| Chemidplus:0000465009 |
References:
| | (4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 73641 |
| Pubchem (cas): | 465-00-9 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11- | dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | | | olean-12-en-28-oic acid, 2,3,23-trihydroxy-, (2alpha,3beta,4alpha)- | | 2,3,23- | trihydroxyolean-12-en-28-oic acid |
Articles:
| PubMed:Flavonoids and triterpenes from Combretum fragrans with anti-inflammatory, antioxidant and antidiabetic potential. |
| PubMed:Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum (Combretaceae) leaf extracts. |
| PubMed:Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. |
| PubMed:Arjunolic Acid Improves the Serum Level of Vitamin B12and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress. |
| PubMed:Self-assembly of Renewable Nano-sized Triterpenoids. |
| PubMed:The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. |
| PubMed:Biological activities of triterpenoids from Poraqueiba sericea stems. |
| PubMed:A Novel Trihybrid Material Based on Renewables: An Efficient Recyclable Heterogeneous Catalyst for C-C Coupling and Reduction Reactions. |
| PubMed:Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-β type 1 receptor. |
| PubMed:Evaluation of herb-drug interaction of a polyherbal Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay. |
| PubMed:[Chemical Constituents from Semiliquidambar cathayensis Roots]. |
| PubMed:Antidiabetic activity of the chemical constituents of Combretum dolichopetalum root in mice. |
| PubMed:Discovery of arjunolic acid as a novel non-zinc binding carbonic anhydrase II inhibitor. |
| PubMed:Screening of Panamanian Plant Extracts for Pesticidal Properties and HPLC-Based Identification of Active Compounds. |
| PubMed:The effect of 3β, 6β, 16β-trihydroxylup-20(29)-ene lupane compound isolated from Combretum leprosum Mart. on peripheral blood mononuclear cells. |
| PubMed:Arjunolic acid protects against DNCB-induced atopic dermatitis-like symptoms in mice by restoring a normal cytokine balance. |
| PubMed:Renal protective effects of arjunolic acid in a cisplatin-induced nephrotoxicity model. |
| PubMed:Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leave in hyperlipidemic mice. |
| PubMed:A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena. |
| PubMed:Arjunolic acid, a pentacyclic triterpenoidal saponin of Terminalia arjuna bark protects neurons from oxidative stress associated damage in focal cerebral ischemia and reperfusion. |
| PubMed:Arjunolic acid ameliorates reactive oxygen species via inhibition of p47(phox)-serine phosphorylation and mitochondrial dysfunction. |
| PubMed:A New Aromatic Compound from the Stem Bark of Terminalia catappa. |
| PubMed:[Chemical constituents of Osmanthus fragrans]. |
| PubMed:Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae--Evidence for a metabolic partnership. |
| PubMed:Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. |
| PubMed:[Anthraquinones and triterpenoids from roots of Knoxia roxburghii]. |
| PubMed:Protective effect of arjunolic acid against atorvastatin induced hepatic and renal pathophysiology via MAPK, mitochondria and ER dependent pathways. |
| PubMed:Chemical constituents of Tilia taquetii leaves and their inhibition of MMP-1 expression and elastase activities. |
| PubMed:Amelioration of cisplatin-induced nephrotoxicity in rats by triterpenoid saponin of Terminalia arjuna. |
| PubMed:Disruption of glucose tolerance caused by glucocorticoid excess in rats is partially prevented, but not attenuated, by arjunolic acid. |
| PubMed:Anti-inflammatory activity of constituents isolated from Terminalia chebula. |
| PubMed:Antibacterial oleanane-type triterpenoids from pericarps of Akebia trifoliata. |
| PubMed:Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid. |
| PubMed:Protective effects of arjunolic acid against cardiac toxicity induced by oral sodium nitrite: effects on cytokine balance and apoptosis. |
| PubMed:Terminalia arjuna in coronary artery disease: ethnopharmacology, pre-clinical, clinical & safety evaluation. |
| PubMed:Counteraction of Bothrops snake venoms by Combretum leprosum root extract and arjunolic acid. |
| PubMed:Modes of action of arjunolic acid and derivatives on Trypanosoma cruzi cells. |
| PubMed:An update on oxidative stress-mediated organ pathophysiology. |
| PubMed:Triterpenoids and flavonoids fromCecropia schreberianaMiq. (Urticaceae). |
| PubMed:Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine. |
| PubMed:Self-assembly of ketals of arjunolic acid into vesicles and fibers yielding gel-like dispersions. |
| PubMed:Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice. |
| PubMed:Microwave extraction and rapid isolation of arjunic acid from Terminalia arjuna (Roxb. ex DC.) stem bark and quantification of arjunic acid and arjunolic acid using HPLC-PDA technique. |
| PubMed:Cytotoxicity of semisynthetic acetal triterpenes from one-pot vicinal diol cleavage following by lactolization: reaction promoted by NaIO4/SiO2 gel in THF. |
| PubMed:Arjunolic acid: beneficial role in type 1 diabetes and its associated organ pathophysiology. |
| PubMed:Unusual isomeric corniculatolides from mangrove, Aegiceras corniculatum. |
| PubMed:Impaired redox signaling and mitochondrial uncoupling contributes vascular inflammation and cardiac dysfunction in type 1 diabetes: Protective role of arjunolic acid. |
| PubMed:Isolation, characterisation and cytotoxicity study of arjunolic acid from Terminalia arjuna. |
| PubMed:Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models. |
| PubMed:The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis. |
| PubMed:Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro. |
| PubMed:Triterpenoid saponins from Symplocos lancifolia. |
| PubMed:Arjunolic acid: a novel phytomedicine with multifunctional therapeutic applications. |
| PubMed:In vivo antifungal effect of Combretum and Terminalia species extracts on cutaneous wound healing in immunosuppressed rats. |
| PubMed:Biorefinery: a design tool for molecular gelators. |
| PubMed:Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. |
| PubMed:A new triterpenoid saponin from the stem of Akebia trifoliata var. australis. |
| PubMed:Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: protective role of arjunolic acid. |
| PubMed:Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection. |
| PubMed:Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: therapeutic potential of arjunolic acid. |
| PubMed:Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: activation of polyol pathway and oxidative stress responsive signaling cascades. |
| PubMed:[Triterpenoids from leaves of Ilex cornuta]. |
| PubMed:[Chemical constituents from roots of Phlomis umbrosa]. |
| PubMed:Induction of neuronal differentiation in neurosphere stem cells by ellagic acid derivatives. |
| PubMed:Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. |
| PubMed:Self-assembly of esters of arjunolic acid into fibrous networks and the properties of their organogels. |
| PubMed:Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. |
| PubMed:Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors. |
| PubMed:Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity. |
| PubMed:A simple route for renewable nano-sized arjunolic and asiatic acids and self-assembly of arjuna-bromolactone. |
| PubMed:Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. |
| PubMed:Biological activity of two related triterpenes isolated from Combretum nelsonii (Combretaceae) leaves. |
| PubMed:Urease inhibitor from Datisca cannabina linn. |
| PubMed:Arjunolic acid attenuates arsenic-induced nephrotoxicity. |
| PubMed:Protection of arsenic-induced testicular oxidative stress by arjunolic acid. |
| PubMed:Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. |
| PubMed:Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid. |
| PubMed:Protection of arsenic-induced hepatic disorder by arjunolic acid. |
| PubMed:Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes. |
| PubMed:Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa. |
| PubMed:Triterpenes and flavonol glucuronides from Oenothera cheiranthifolia. |
| PubMed:Donor-acceptor interaction promoted gelation: visual observation of color change. |
| PubMed:Secondary metabolites from the wood bark of Durio zibethinus and Durio kutejensis. |
| PubMed:New triterpenoids isolated from the root bark of Ulmus pumila L. |
| PubMed:Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors. |
| PubMed:Antibacterial triterpenes from Syzygium guineense (Myrtaceae). |
| PubMed:Antileishmanial activity of isolated triterpenoids from Pourouma guianensis. |
| PubMed:A new triterpene from Leandra chaetodon. |
| PubMed:Flavanone glycosides from Miconia trailii. |
| PubMed:Quantitative determination of oleane derivatives in Terminalia arjuna by high performance thin layer chromatography. |
| PubMed:RP-LC determination of oleane derivatives in Terminalia arjuna. |
| PubMed:Insect growth inhibitor activity of arjunolic acid isolated from Cornus capitata. |
| PubMed:Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. |
| PubMed:Terminalia arjuna. |
| PubMed:[Studies on the chemical components from leaves of Luffa cylinderica Roem]. |
| PubMed:Studies on inhibitors of skin-tumor promotion. Inhibitory effects of triterpenes from Cochlospermum tinctorium on Epstein-Barr virus activation. |
| PubMed:[Hormonal action of the "corticosteroid type" of 2 triterpenes: arjunolic acid and asiatic acid]. |
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3D/inchi