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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 4.369 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for nectandrin-B usage levels up to: | | | not for fragrance use.
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| Recommendation for nectandrin-B flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 4-[(2R,3R,4S,5S)-5-(4-hydroxy-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 156517 |
| Pubchem (cas): | 74683-16-2 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | calophyllin | | 4-[(2R,3R,4S,5S)-5-(4- | hydroxy-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenol | | | malabaricanol | | | nectandrin B | | | phenol, 4,4'-((2R,3R,4S,5S)-tetrahydro-3,4-dimethyl-2,5-furandiyl)bis(2-methoxy-, rel- |
Articles:
| PubMed:Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. |
| PubMed:Bioactivity-Guided Investigation of the Anti-Inflammatory Activity of Hippophae rhamnoides Fruits. |
| PubMed:Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes. |
| PubMed:Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β. |
| PubMed:Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3. |
| PubMed:The Blood-Brain Barrier Permeability of Lignans and Malabaricones from the Seeds of Myristica fragrans in the MDCK-pHaMDR Cell Monolayer Model. |
| PubMed:Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-α-induced hepatic lipogenesis through AMP-activated protein kinase activation. |
| PubMed:Nectandrin B suppresses the expression of adhesion molecules in endothelial cells: Role of AMP-activated protein kinase activation. |
| PubMed:[Lignans from Machilus robusta]. |
| PubMed:Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans. |
| PubMed:Glycosides from the bark of Machilus robusta. |
| PubMed:Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation. |
| PubMed:[Chemical constituents from roots of Machilus yaoshansis]. |
| PubMed:Nectandrin B activates endothelial nitric-oxide synthase phosphorylation in endothelial cells: role of the AMP-activated protein kinase/estrogen receptor α/phosphatidylinositol 3-kinase/Akt pathway. |
| PubMed:Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells. |
| PubMed:AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. |
| PubMed:Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis. |
| PubMed:Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation. |
| PubMed:In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae). |
| PubMed:Protective effect of lignans against sepsis from the roots of Saururus chinensis. |
| PubMed:Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi. |
| PubMed:Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum. |
| PubMed:Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans. |
| PubMed:Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells. |
| PubMed:Lignans from the bark of Machilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity. |
| PubMed:Melanin biosynthesis inhibitors from the bark of Machilus thunbergii. |
| PubMed:Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities. |
| PubMed:Antiproliferative, anti-aromatase, anti-17beta-HSD and antioxidant activities of lignans isolated from Myristica argentea. |
| PubMed:Chemical constituents of two Chinese Magnoliaceae plants, Tsoongiodendron odorum and Manglietiastrum sinicum, and their inhibition of platelet aggregation. |
| PubMed:O-demethylation of 7,7'-epoxylignans by Aspergillus niger. |
| PubMed:Antitumor plants. X. Constituents of Nectandra rigida. |
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3D/inchi