ethylene oxide/propylene oxide copolymer
poloxamer

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  Product(s):
  106392-12-5 Poloxamer

CAS Number: 106392-12-5 3D/inchi Other(deleted CASRN): 11104-97-5 FDA UNII: Search Molecular Weight: 102.13310000 Formula: C5 H10 O2 NMR Predictor: Predict (works with chrome, Edge or firefox) Category:indirect food additives: adhesives and components of coatings   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search FDA Mainterm (SATF): 9003-11-6 ; ETHYLENE OXIDE/PROPYLENE OXIDE COPOLYMER FDA Mainterm (IAUFC): 9003-11-6 ; POLY(ETHYLENE OXIDE-CO-PROPYLENE OXIDE), BLOCK   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Poloxamer   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intraperitoneal-mouse LD50 420 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. intravenous-mouse LD50 129 mg/kg Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 569, 1993. intravenous-mouse LD50 1000 mg/kg Microvascular Research. Vol. 8, Pg. 320, 1974. intravenous-mouse LD50 3000 mg/kg Drugs in Japan Vol. 6, Pg. 797, 1982. oral-mouse LD50 > 30300 ug/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981. oral-mouse LD50 1830 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. oral-mouse LD50 15000 mg/kg Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962. unreported-mouse LD50 400 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 530 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 750 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 830 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 1250 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 1400 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 2250 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 2700 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 3000 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 3750 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 4200 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 > 5000 mg/kg United States Patent Document. Vol. #4043344 intraperitoneal-rat LD50 320 mg/kg LIVER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA National Technical Information Service. Vol. OTS0540972 intraperitoneal-rat LD50 1140 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. intravenous-rat LD50 7500 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981. oral-rat LD50 > 30300 ug/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981. oral-rat LD50 2300 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. oral-rat LD50 5000 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION Wyandotte Chemicals Corporation Reports. oral-rat LD50 9380 mg/kg "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 297, 1972. oral-rat LD50 22400 mg/kg Union Carbide Data Sheet. Vol. 7/14/1965 Dermal Toxicity: subcutaneous-mouse LD50 5500 mg/kg Drugs in Japan Vol. 6, Pg. 797, 1982. skin-rabbit LD50 > 5000 mg/kg Union Carbide Data Sheet. Vol. 7/14/1965 subcutaneous-rat LD50 6900 mg/kg Drugs in Japan Vol. 6, Pg. 797, 1982. Inhalation Toxicity: Not determined   Safety in Use Information: Category: indirect food additives: adhesives and components of coatings Recommendation for ethylene oxide/propylene oxide copolymer usage levels up to:   not for fragrance use.   Recommendation for ethylene oxide/propylene oxide copolymer flavor usage levels up to:   not for flavor use.   Safety References: ClinicalTrials.gov:search Daily Med:search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :24751 National Institute of Allergy and Infectious Diseases:Data 2-methyloxirane;oxirane Chemidplus:0106392125   References:   2-methyloxirane;oxirane NIST Chemistry WebBook: Search Inchi Pubchem (cid): 24751 Pubchem (cas): 106392-12-5   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements FDA Indirect Additives used in Food Contact Substances: View CHEBI: View KEGG (GenomeNet): D01941 HMDB (The Human Metabolome Database): HMDB32263 FooDB: FDB009380 ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms:   methyloxirane polymer with oxirane block 2- methyloxirane;oxirane   poloxalene   poloxamer   polyoxyethylene - polyoxypropylene block copolymer   propylene oxide ethylene oxide block polymer   Articles:   None found yet. 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Notes: None found