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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 4.105e-006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for euphol usage levels up to: | | | not for fragrance use.
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| Recommendation for euphol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :441678 |
| National Institute of Allergy and Infectious Diseases:Data |
| (3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Chemidplus:0000514476 |
References:
| | (3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 441678 |
| Pubchem (cas): | 514-47-6 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | eupha-8,24-dienol | | 13-alpha,14-beta,17-beta-H- | lanosta-8,24-dien-3-beta-ol (7CI,8CI) | | (3S,5R,10S,13S,14S,17S)-4,4,10,13,14- | pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol |
Articles:
| PubMed:Comparative Transcriptome Analysis Identifies Putative Genes Involved in Steroid Biosynthesis in Euphorbia tirucalli. |
| PubMed:[Acute toxicity of Euphorbiae Pekinensis Radix and vinegar-processing Euphorbiae Pekinensis Radix on zebrafish embryo]. |
| PubMed:Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research. |
| PubMed:Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities. |
| PubMed:Antibacterial activities of the methanol extract, fractions and compounds from Elaeophorbia drupifera (Thonn.) Stapf. (Euphorbiaceae). |
| PubMed:Cytotoxic biomonitored study of Euphorbia umbellata (Pax) Bruyns. |
| PubMed:Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. |
| PubMed:The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε. |
| PubMed:Chemical Constituents from the Leaves of Euphorbia ammak Growing in Saudi Arabia. |
| PubMed:[Chemical constituents from Euphorbia lunulata]. |
| PubMed:Quantitative determination of euphol in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. |
| PubMed:Chemical and pharmacological investigation of the stem bark of Synadenium grantii. |
| PubMed:Minor ent-abietane diterpenoids from Euphorbia guyoniana. |
| PubMed:Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex. |
| PubMed:Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. |
| PubMed:Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae). |
| PubMed:Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. |
| PubMed:The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. |
| PubMed:[Optimization of vinegar processing technique of Euphorbia pekinensis by multi-index orthogonal test]. |
| PubMed:Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. |
| PubMed:Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. |
| PubMed:Euphol prevents experimental autoimmune encephalomyelitis in mice: evidence for the underlying mechanisms. |
| PubMed:Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. |
| PubMed:Antileishmanial and antitrypanosomal activity of triterpene derivatives from latex of two Euphorbia species. |
| PubMed:[Anti-HBV constituents from Euphorbia fischeriana]. |
| PubMed:Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae). |
| PubMed:Discovery of potent and reversible monoacylglycerol lipase inhibitors. |
| PubMed:Bioactive triterpene derivatives from latex of two Euphorbia species. |
| PubMed:[Study on chemical constituents of Euphorbia hylonoma hand. -Mazz]. |
| PubMed:[Studies on constituents from roots of Euphorbia hylonoma]. |
| PubMed:[Studies on chemical constitutes of green alga Chaetomorpha basiretorsa and their bioactivity]. |
| PubMed:Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase. |
| PubMed:A new tetracyclic triterpene from the latex of Euphorbia nerifolia. |
| PubMed:Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus. |
| PubMed:Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation. |
| PubMed:Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. |
| PubMed:Triterpene alcohols from camellia and sasanqua oils and their anti-inflammatory effects. |
| PubMed:[Triterpene constituents from Euphorbia nematocypha Hand-Mazz]. |
| PubMed:Analysis of a thread used in the Kshara Sutra treatment in the Ayurvedic medicinal system. |
| PubMed:Hypotensive activity of 8,24-euphadien-3 beta-ol (euphol). |
| PubMed:Studies in the Chemical Constituents of Azadirachta indica Part II: Isolation and Structure of the New Triterpenoid Azadirachtol. |
| PubMed:Rotational isomerism about the 17(20)-bond of steroids and euphoids as shown by the crystal structures of euphol and tirucallol. |
| PubMed:[Studies on the constituents of Chinese drug "kanzui." 8. KMnO4 oxidation of euphol, tirucallol and beta-euphorbol]. |
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3D/inchi