|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 34.05 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for (+)-aspidospermidine usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for (+)-aspidospermidine flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
Articles:
| PubMed:Directed Fischer Indolization as an Approach to the Total Syntheses of (+)-Aspidospermidine and (-)-Tabersonine. |
| PubMed:Efficient syntheses of (-)-crinine and (-)-aspidospermidine, and the formal synthesis of (-)-minfiensine by enantioselective intramolecular dearomative cyclization. |
| PubMed:Total Synthesis of (-)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution. |
| PubMed:Divergent Asymmetric Total Synthesis of (+)-Vincadifformine, (-)-Quebrachamine, (+)-Aspidospermidine, (-)-Aspidospermine, (-)-Pyrifolidine, and Related Natural Products. |
| PubMed:Development and Scope of the Arene-Fused Domino Michael/Mannich Reaction: Application to the Total Syntheses of Aspidosperma Alkaloids (-)-Aspidospermidine, (-)-Tabersonine, and (-)-Vincadifformine. |
| PubMed:Enantioselective Pd-Catalyzed Allylic Alkylation Reactions of Dihydropyrido[1,2-a]indolone Substrates: Efficient Syntheses of (-)-Goniomitine, (+)-Aspidospermidine, and (-)-Quebrachamine. |
| PubMed:Efficient Strategy for the Construction of Both Enantiomers of the Octahydropyrroloquinolinone Ring System: Total Synthesis of (+)-Aspidospermidine. |
| PubMed:Preparation of the Core Structure of Aspidosperma and Strychnos Alkaloids from Aryl Azides by a Cascade Radical Cyclization. |
| PubMed:Aqueous Titanium Trichloride Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine. |
| PubMed:Concise total synthesis of (±)-aspidospermidine. |
| PubMed:Unified strategy to monoterpene indole alkaloids: total syntheses of (±)-goniomitine, (±)-1,2-dehydroaspidospermidine, (±)-aspidospermidine, (±)-vincadifformine, and (±)-kopsihainanine A. |
| PubMed:Pd(II)-catalyzed one-step construction of cycloalkane-fused indoles and its application in formal synthesis of (±)-aspidospermidine. |
| PubMed:Domino Michael/Mannich/N-alkylation route to the tetrahydrocarbazole framework of aspidosperma alkaloids: concise total syntheses of (-)-aspidospermidine, (-)-tabersonine, and (-)-vincadifformine. |
| PubMed:Enantioselective palladium-catalyzed decarboxylative allylation of carbazolones: total synthesis of (-)-aspidospermidine and (+)-kopsihainanine A. |
| PubMed:Regioselective inter- and intramolecular formal [4+2] cycloaddition of cyclobutanones with indoles and total synthesis of (±)-aspidospermidine. |
| PubMed:Chemical synthesis of Aspidosperma alkaloids inspired by the reverse of the biosynthesis of the rhazinilam family of natural products. |
| PubMed:Pd(II)-catalyzed regioselective 2-alkylation of indoles via a norbornene-mediated C-H activation: mechanism and applications. |
| PubMed:Indole alkaloids synthesis via a selective cyclization of aminocyclopropanes. |
| PubMed:Cyclopropanes and hypervalent iodine reagents: high energy compounds for applications in synthesis and catalysis. |
| PubMed:Synthetic studies on amaryllidaceae and other terrestrially derived alkaloids. |
| PubMed:Collective synthesis of natural products by means of organocascade catalysis. |
| PubMed:Catalytic selective cyclizations of aminocyclopropanes: formal synthesis of aspidospermidine and total synthesis of goniomitine. |
| PubMed:Evidence for a role of 5-HT(1A) receptor on antinociceptive action from Geissospermum vellosii. |
| PubMed:Concise total synthesis of (+/-)-aspidospermidine via an oxidative Hosomi-Sakurai process. |
| PubMed:Asymmetric construction of quaternary carbon centers by sequential conjugate addition of lithium amide and in situ alkylation: utility in the synthesis of (-)-aspidospermidine. |
| PubMed:Stereoselective formation of fused tricyclic amines from acyclic aldehydes by a cascade process involving condensation, cyclization, and dipolar cycloaddition. |
| PubMed:Domino double Michael-Claisen cyclizations: a powerful general tool for introducing quaternary stereocenters at C4 of cyclohexane-1,3-diones and total synthesis of diverse families of sterically congested alkaloids. |
| PubMed:Highly efficient synthesis of tricyclic amines by a cyclization/cycloaddition cascade: total syntheses of aspidospermine, aspidospermidine, and quebrachamine. |
| PubMed:Formal synthesis of aspidosperma alkaloids via the intramolecular [3 + 2] cycloaddition of 2-azapentdienyllithiums. |
| PubMed:A short total synthesis of (+/-)-aspidospermidine. |
| PubMed:Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine. |
| PubMed:A study of vinyl radical cyclization using N-alkenyl-7-bromo-substituted hexahydroindolinones. |
| PubMed:Exploiting the palladium[0]-catalysed Ullmann cross-coupling reaction in natural products chemistry: application to a total synthesis of the alkaloid (+/-)-aspidospermidine. |
| PubMed:Total synthesis of (+)-aspidospermidine: a new strategy for the enantiospecific synthesis of aspidosperma alkaloids. |
| PubMed:Antiplasmodial activity of aspidosperma indole alkaloids. |
| PubMed:An efficient approach to Aspidosperma alkaloids via [4 + 2] cycloadditions of aminosiloxydienes: stereocontrolled total synthesis of (+/-)-tabersonine. Gram-scale catalytic asymmetric syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric syntheses of (+)-aspidospermidine and (-)-quebrachamine. |
| PubMed:Tandem radical cyclizations with iodoaryl azides: formal total synthesis of (+/-)-aspidospermidine. |
| PubMed:Regiocontrol in an intramolecular Schmidt reaction: total synthesis of (+)-aspidospermidine. |
| PubMed:Novel [1,5] sigmatropic rearrangements of cyclohexadienones generated from Fischer carbene complexes. A new strategy for installing the C-20 angular ethyl group in Aspidospermidine alkaloids. |
| PubMed:Total synthesis of (+/-)-aspidospermidine. |
| PubMed:Synthetic Applications of 2-(1,3-Dithian-2-yl)indoles. 7. Synthesis of Aspidospermidine. |
| PubMed:Alkaloids from Aspidosperma species from Bolivia. |
| PubMed:Total synthesis of indole and dihydroindole alkaloids. V. The total synthesis of dl-quebrachamine and dl-aspidospermidine. A general entry into the aspidosperma alkaloids. |
| PubMed:Cyclization in the cleavamine series: x-ray analysis of N(a)-acetyl-7-ethyl-5-desethyl-aspidospermidine N(b)-methiodide. |
|
3D/inchi