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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 10.17 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for zapotin usage levels up to: | | | not for fragrance use.
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| Recommendation for zapotin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2-(2,6- | dimethoxyphenyl)-5,6-dimethoxychromen-4-one | | 5,6,2',6'- | tetramethoxyflavone |
Articles:
| PubMed:Antidepressant-like effect of Casimiroa pubescens root extracts. |
| PubMed:Zapotin (5,6,2',6'-tetramethoxyflavone) Modulates the Crosstalk Between Autophagy and Apoptosis Pathways in Cancer Cells with Overexpressed Constitutively Active PKCϵ. |
| PubMed:The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. |
| PubMed:Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms. |
| PubMed:Zapotin prevents mouse skin tumorigenesis during the stages of initiation and promotion. |
| PubMed:Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis. |
| PubMed:Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. |
| PubMed:Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. |
| PubMed:Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells. |
| PubMed:Plant antitumor agents, 21. Flavones, coumarins, and an alkaloid from Sargentia greggii. |
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