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Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1.559e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic ingredient for skin conditioning |
| Recommendation for rhododendrol usage levels up to: | | | not for fragrance use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzenepropanol, 4-hydroxy-alpha-methyl- | | 4-(3- | hydroxybutyl)phenol | | 4-(p- | hydroxyphenyl)-2-butanol | | 4-(p- | hydroxyphenyl)butan-2-ol | | | raspberry ketone alcohol |
Articles:
| PubMed:Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol. |
| PubMed:The effect of rhododendrol inhibition of NF-κB on melanocytes in the presence of tyrosinase. |
| PubMed:The spectrophotometrical analysis of rhododendrol-induced leucoderma using a novel multispectral camera. |
| PubMed:Biochemical effects of the flavanol-rich lychee fruit extract on the melanin biosynthesis and reactive oxygen species. |
| PubMed:Rhododenol and raspberry ketone impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45. |
| PubMed:NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol. |
| PubMed:[Leukoderma caused by chemicals: mechanisms underlying 4-alkyl/aryl-substituted phenols- and rhododendrol-induced melanocyte loss]. |
| PubMed:T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma. |
| PubMed:Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin. |
| PubMed:Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes. |
| PubMed:Rhododendrol glycosides as stereospecific tyrosinase inhibitors. |
| PubMed:Effects of rhododendrol and its metabolic products on melanocytic cell growth. |
| PubMed:A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols. |
| PubMed:Rhododendrol-induced leukoderma accompanied by allergic contact dermatitis caused by a non-rhododendrol skin-lightening agent, 5,5'-dipropylbiphenyl-2,2'-diol. |
| PubMed:The mechanism of melanocytes-specific cytotoxicity induced by phenol compounds having a prooxidant effect, relating to the appearance of leukoderma. |
| PubMed:Possible involvement of CCR4+ CD8+ T cells and elevated plasma CCL22 and CCL17 in patients with rhododenol-induced leukoderma. |
| PubMed:Biochemical, cytological, and immunological mechanisms of rhododendrol-induced leukoderma. |
| PubMed:Melanocyte-specific cytotoxic T lymphocytes in patients with rhododendrol-induced leukoderma. |
| PubMed:Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins. |
| PubMed:4-(4-hydroroxyphenyl)-2-butanol (rhododendrol) activates the autophagy-lysosome pathway in melanocytes: insights into the mechanisms of rhododendrol-induced leukoderma. |
| PubMed:An immune pathological and ultrastructural skin analysis for rhododenol-induced leukoderma patients. |
| PubMed:[Phenolic compounds from Rhododendron phaeochrysum var. agglutinatum]. |
| PubMed:Human tyrosinase is able to oxidize both enantiomers of rhododendrol. |
| PubMed:Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold. |
| PubMed:Tyrosinase-catalyzed oxidation of rhododendrol produces 2-methylchromane-6,7-dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity. |
| PubMed:Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. |
| PubMed:Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides. |
| PubMed:Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum. |
| PubMed:Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense. |
| PubMed:Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense. |
| PubMed:(+)-rhododendrol and epi-rhododendrin suppress the NO production by activated macrophages in vivo. |
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3D/inchi