EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

4-hydroxyphenyl a-D-glucopyranoside

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CAS Number: 84380-01-8Picture of molecule3D/inchi
Nikkaji Web:J593.405B
Beilstein Number:89675
XlogP3-AA:-0.70 (est)
Molecular Weight:272.25392000
Formula:C12 H16 O7
NMR Predictor:Predict (works with chrome or firefox)
Category:antioxidant, bleaching, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 9.591e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
skin conditioning
Alfa Biotechnology
For experimental / research use only.
a-Arbutin 98%
BOC Sciences
For experimental / research use only.
ECSA Chemicals
Glentham Life Sciences
Jiangyin Healthway
New functional food ingredients
For experimental / research use only.
Alpha-arbutin 99%
Shaanxi Y-Herb Biotechnology
Pure Alpha Arbutin 99% Bearberry Extract Powder For Skin Whiting CAS 84380-01-8
For experimental / research use only.
a-Arbutin analytical standard
Spec-Chem Industry
SpecWhite ® 03(A-arbutin)
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
antioxidant, bleaching, skin conditioning
Recommendation for alpha-arbutin usage levels up to:
 not for fragrance use.
Recommendation for alpha-arbutin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :158637
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):158637
Pubchem (sid):135114345
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C12079
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
a-D-glucopyranoside, 4-hydroxyphenyl
4-hydroxyphenyl a-D-glucopyranoside


PubMed:Assessment of a Novel Anti-Aging Hand Cream.
PubMed:Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of α-arbutin in cosmetic products.
PubMed:Comparative studies on the chemical and enzymatic stability of alpha- and beta-arbutin.
PubMed:Quantitative Determination of α-Arbutin, β-Arbutin, Kojic Acid, Nicotinamide, Hydroquinone, Resorcinol, 4-Methoxyphenol, 4-Ethoxyphenol, and Ascorbic Acid from Skin Whitening Products by HPLC-UV.
PubMed:Dual effects of alpha-arbutin on monophenolase and diphenolase activities of mushroom tyrosinase.
PubMed:Penetration depth, concentration and efficiency of transdermal α-arbutin delivery after ultrasound treatment with albumin-shelled microbubbles in mice.
PubMed:Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells.
PubMed:Feeding strategies for the enhanced production of α-arbutin in the fed-batch fermentation of Xanthomonas maltophilia BT-112.
PubMed:[Properties of sucrose phosphorylase from recombinant Escherichia coli and enzymatic synthesis of alpha-arbutin].
PubMed:Isolation of α-arbutin from Xanthomonas CGMCC 1243 fermentation broth by macroporous resin adsorption chromatography.
PubMed:Screening of high α-arbutin producing strains and production of α-arbutin by fermentation.
PubMed:Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivatives.
PubMed:High-yield enzymatic bioconversion of hydroquinone to α-arbutin, a powerful skin lightening agent, by amylosucrase.
PubMed:Sucrose isomerase and its mutants from Erwinia rhapontici can synthesise α-arbutin.
PubMed:Experimental study on cross-reactivity of alpha-arbutin toward p-phenylenediamine and hydroquinone in guinea pigs.
PubMed:Treatment of refractory melasma with the MedLite C6 Q-switched Nd:YAG laser and alpha arbutin: a prospective study.
PubMed:[Determination of alpha-arbutin, beta-arbutin and niacinamide in cosmetics by high performance liquid chromatography].
PubMed:Treatment of refractory dermal melasma with the MedLite C6 Q-switched Nd:YAG laser: two case reports.
PubMed:High cell density cultivation of Escherichia coli with surface anchored transglucosidase for use as whole-cell biocatalyst for alpha-arbutin synthesis.
PubMed:Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products.
PubMed:Surface display of transglucosidase on Escherichia coli by using the ice nucleation protein of Xanthomonas campestris and its application in glucosylation of hydroquinone.
PubMed:A new synthesis of alpha-arbutin via Lewis acid catalyzed selective glycosylation of tetra-O-benzyl-alpha-D-glucopyranosyl trichloroacetimidate with hydroquinone.
PubMed:Syntheses of alpha-arbutin-alpha-glycosides and their inhibitory effects on human tyrosinase.
PubMed:Enzymatic synthesis of alpha-arbutin by alpha-anomer-selective glucosylation of hydroquinone using lyophilized cells of Xanthomonas campestris WU-9701.
PubMed:Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model.
PubMed:Syntheses of arbutin-alpha-glycosides and a comparison of their inhibitory effects with those of alpha-arbutin and arbutin on human tyrosinase.
PubMed:Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.
None found
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