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 Category:natural substances and extractives 
  
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: 
  
Physical Properties: 
| Assay: |  95.00 to 100.00 
 |  
| Food Chemicals Codex Listed:  | No |  
| Boiling Point: |  679.30 °C. @  760.00 mm Hg (est)
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| Flash Point: |  501.00 °F. TCC (  260.60 °C. ) (est)
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| logP (o/w): |   1.160 (est) |  
| Soluble in: |  
|   | water, 5119 mg/L @ 25 °C (est) |  
 
  
Organoleptic Properties: 
| Odor and/or flavor descriptions from others (if found). |  
 
  
Cosmetic Information: 
  
Suppliers: 
  
Safety Information: 
|   |  
| Hazards identification |  
|   |  
|  Classification of the substance or mixture |  
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |  
| None found. |  
|  GHS Label elements, including precautionary statements |  
|   |  
| Pictogram |  |  
|   |  
                                                                     
| Hazard statement(s) |  
| None found. |  
| Precautionary statement(s) |  
| None found. |  
| Oral/Parenteral Toxicity:  |  
| 
Not determined
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| Dermal Toxicity:  |  
| 
Not determined
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| Inhalation Toxicity:  |  
| 
Not determined
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Safety in Use Information: 
| Category:  |  | natural substances and extractives |  
| Recommendation for gossypetin usage levels up to:  |  |   | not for fragrance use.
 |  
|   |  
| Recommendation for gossypetin flavor usage levels up to:  |  
|   | not for flavor use.
 |  
 
  
Safety References: 
  
References: 
  
Other Information: 
  
Potential Blenders and core components  note 
  
Potential Uses: 
  
Occurrence (nature, food, other): note 
  
Synonyms: 
|   | articulatidin |  | 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy- |  | 2-(3,4- | dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one |  |   | equisporol |  | 3,5,7,8,3',4'- | hexahydroxyflavone |  
 
  
Articles:
| PubMed:Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats. |  
| PubMed:Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study. |  
| PubMed:Antiartherosclerotic effects of plant flavonoids. |  
| PubMed:[Chemical constituents of leaves of Psidium guajava]. |  
| PubMed:Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation. |  
| PubMed:LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata. |  
| PubMed:Gossypetin, a naturally occurring hexahydroxy flavone, ameliorates gamma radiation-mediated DNA damage. |  
| PubMed:A critical evaluation on the reliability of two aluminum chloride chelation methods for quantification of flavonoids. |  
| PubMed:[Study on chemical constituents of Drosera peltata var. multisepala]. |  
| PubMed:Flavonoid constituents and free radical scavenging activity of Alchemilla mollis. |  
| PubMed:[Metabolites in rat urine after orally administrating gossypetin-8-O-beta-D-glucuronide]. |  
| PubMed:Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. |  
| PubMed:Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding. |  
| PubMed:Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. |  
| PubMed:Comparative analysis of flavonoid profile, antioxidant and antimicrobial activity of the berries of Juniperus communis L. var. communis and Juniperus communis L. var. saxatilis Pall. from Turkey. |  
| PubMed:Metabolism of hibifolin by human intestinal bacteria. |  
| PubMed:Chemodiversity of exudate flavonoids in Cassinia and Ozothamnus (Asteraceae, Gnaphalieae). |  
| PubMed:Screening of herbal constituents for aromatase inhibitory activity. |  
| PubMed:Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. |  
| PubMed:Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. |  
| PubMed:Anti-oxidant constituents from Sedum takesimense. |  
| PubMed:Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. |  
| PubMed:Bioactive compounds from Rhodiola rosea (Crassulaceae). |  
| PubMed:Antioxidant phenolic constituents from Fagopyrum dibotrys. |  
| PubMed:Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. |  
| PubMed:Polyoxygenated flavonoids from Eugenia edulis. |  
| PubMed:Electrospray mass spectrometric decomposition of some glucuronic acid-containing flavonoid diglycosides. |  
| PubMed:Chemical constituents of Pyrrosia petiolosa. |  
| PubMed:New erythroxane-type diterpenoids from Fagonia boveana (Hadidi) Hadidi & Graf. |  
| PubMed:A novel flavonol lyxoside of Orostachys japonicus herb. |  
| PubMed:UDP-glucose: flavonol 7-O-glucosyltransferase activity in flower extracts of Chrysanthemum segetum. |  
| PubMed:Bioactive constituents of Chinese natural medicines. II. Rhodiolae radix. (1). Chemical structures and antiallergic activity of rhodiocyanosides A and B from the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. (Crassulaceae). |  
| PubMed:Rhodiocyanosides A and B, new antiallergic cyanoglycosides from Chinese natural medicine "si lie hong jing tian", the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. |  
| PubMed:Dietary flavonoids in atherosclerosis prevention. |  
| PubMed:The modification of low density lipoprotein by the flavonoids myricetin and gossypetin. |  
| PubMed:Evaluation of flavonoids inGossypium arboreum (L.) cottons as potential source of resistance to tobacco budworm. |  
| PubMed:Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. |  
| PubMed:Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. |  
| PubMed:Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. |  
| PubMed:Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. |  
| PubMed:Loss of plasmid linked antibiotic resistance in Escherichia coli on treatment with some phenolic compounds. |  
| PubMed:C18 solid-phase isolation and high-performance liquid chromatography/ultraviolet diode array determination of fully methoxylated flavones in citrus juices. |  
| PubMed:Flavonoids from Picnomon acarna. |  
 
  
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