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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 177.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 795.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 814.00 °F. TCC ( 434.60 °C. ) (est)
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| logP (o/w): | 3.510 (est) |
| Soluble in: |
| | water, 0.2656 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 101 mg/kg
Drugs in Japan Vol. 6, Pg. 365, 1982.
oral-mouse LD50 1293 mg/kg
Drugs in Japan Vol. 6, Pg. 365, 1982.
intraperitoneal-rat LD50 286 mg/kg
Drugs in Japan Vol. 6, Pg. 365, 1982.
intravenous-rat LD50 50 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 245, 1959.
oral-rat LD50 > 2000 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 281 mg/kg
Drugs in Japan Vol. 6, Pg. 365, 1982.
subcutaneous-rat LD50 > 2000 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for syrosingopine usage levels up to: | | | not for fragrance use.
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| Recommendation for syrosingopine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 4-hydroxy-3,5-dimethoxy-, ethyl carbonate, ester with methyl reserpate | | | carbethoxysyringoyl methylreserpate | | 18-O-(3,5- | dimethoxy-4-ethoxycarbonyloxybenzoyl)eserpsaeuremethylester | | | elufinesin | | | etropres | | | ipores | | | londomin | | | menatensina | | | methyl 18-O-(4-ethoxycarbonyloxy-3,5-dimethoxybenzyoyl)reserpat | | | methyl 18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-carboxylate 4-hydroxy | | | methyl reserpate ester of syringic acid ethyl carbonate | | | methyl reserpate, 4-ethoxycarbonyl-3,5-dimethoxybenzoic acid ester | | | neoreserpan | | | nichiserpine-S | | | novoserpina | | | reserpic acid, methyl ester, ester with 4-hydroxy-3,5-dimethoxybenzoic acid ethyl carbonate | | | revelox-wirkstoff | | | seringina | | | serpagon | | | singoserp | | | siringal | | | siringina | | | siringone | | | siriserpin | | | siroshuten | | | sirosingopina | | | syringic acid ethyl carbonate ester with methyl reserpate | | | syringopine | | | syrosingopin | | | syrosingopinum | | iso | tense | | | vegaserpina | | | yohimban-16-carboxylic acid, 18-((4-((ethoxycabonyl)oxy)-3,5-dimethoxybenzoyl)oxy)-11,17-dimethoxy-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)- | | 3beta,20alpha- | yohimban-16beta-carboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy-, methyl ester, 4-hydroxy-3,5-dimethoxybenzoate (ester) ethyl carbonate (ester) (8CI) | | | zentos
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Articles:
| PubMed:Adrenergic and nonadrenergic cotransmitters inhibit insulin secretion during sympathetic stimulation in dogs. |
| PubMed:Measurement and cardiovascular relevance of partial agonist activity (PAA) involving beta 1- and beta 2-adrenoceptors. |
| PubMed:Reversal of resistance to vincristine in P388 leukemia by various polycyclic clinical drugs, with a special emphasis on quinacrine. |
| PubMed:Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. |
| PubMed:Effects of amnesic doses of reserpine or syrosingopine on mouse brain acetylcholine levels. |
| PubMed:Enhancement of phenol-induced tremor caused by central monoamine depletion. |
| PubMed:Fluorescence histochemical studies of the effects of rauwolfia alkaloid derivatives on adrenergic vasomotor nerves. |
| PubMed:Facilitation of calcium blocking and membrane effects by intrinsic sympathomimetic activity. |
| PubMed:The effect of reserpine, syrosingopine, and guanethidine on the retention of discriminated escape reversal: peripherally administered catecholamines cannot reverse the reserpine amnesia in this situation. |
| PubMed:Rat endometrial bioelectric activity in vivo and in vitro: effects of adrenaline. |
| PubMed:Effect of an amnesic dose of reserpine, syrosingopine or guanethidine on the levels of whole brain dopamine and norepinephrine in the mouse. |
| PubMed:Effects of mianserin, desipramine and maprotiline on blood pressure responses evoked by acetylcholine, histamine and 5-hydroxytryptamine in rats. |
| PubMed:Modification of the vasomotor actions of methysergide in the femoral arterial bed of the anaesthetized dog by changes in sympathetic nerve activity. |
| PubMed:An analysis of the mechanism of 5-hydroxytryptamine-induced vasopressor responses in ganglion-blocked anaesthetized dogs. |
| PubMed:Prolactin secretion during reserpine and syrosingopine treatment. |
| PubMed:Stimulation of peripheral dopamine receptors in rats: a mechanism for novel antihypertensive agents. |
| PubMed:Antibody specificity studies for reserpine, its metabolites, and synthetic reserpine congeners: radioimmunoassay. |
| PubMed:Comparison of the long-term cumulative effects of reserpine and syrosingopine on general activity. |
| PubMed:Memory storage impairment or retrieval failure: pharmacologically distinguishable processes. |
| PubMed:Peripheral catecholamines and memory: characteristics of syrosingopine-induced amnesia. |
| PubMed:Serotonergic function in mouse head twitches induced by lithium and reserpine. |
| PubMed:A study of the relationship between cardiac beta-adrenoceptor blockade and intrinsic sympathomimetic activity in rats depleted of catecholamines. |
| PubMed:The effects of alpha-adrenoceptor antagonists on contractile responses to 5-hydroxytryptamine in dog saphenous vein. |
| PubMed:The selective action of beta-adrenoceptor blocking drugs and the nature of beta1 and beta2 adrenoceptors. |
| PubMed:Analysis of the inotropic: chronotropic selectivity of dobutamine and dopamine in anaethetised dogs and guinea-pig isolated atria. |
| PubMed:Selective depleting effect of syrosingopine on brain catecholamine levels with relation to morphine analgesia in the rat. |
| PubMed:Role of catecholamines in the central mechanism of emetic response induced by peruvoside and ouabain in cats. |
| PubMed:A non-adrenergic inhibitory nervous pathway in guinea-pig trachea. |
| PubMed:[Effects of repeated administration of ephedrine and pre-treatment with syrosingopine on the sympathetic ganglia]. |
| PubMed:[Central and other pharmacological actions of syrosingopine (O-carbethoxysyringoyl methylreserpate)]. |
| PubMed:Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors. |
| PubMed:Automated fluorometric analysis of reserpine and syrosingopine tablets, using a vanadium pentoxide reagent. |
| PubMed:Preliminary evidence that syrosingopine produces a selective depletion of central stores of sympathomimetic amines. |
| PubMed:Comparative chronotropic activity of beta-adrenoceptive antagonists. |
| PubMed:The effect of reserpine on the pressor responses to angiotensin in the conscious cat. |
| PubMed:[Fluctuation in the catecholamine level in the guinea pig tissues induced by syrosingopine]. |
| PubMed:[Comparison of the sedative effects of reserpine, syrosingopine and bietaserpine on the behavior of mice]. |
| PubMed:The effect of reserpine and syrosingopine upon pentobarbital depression. |
| PubMed:Effect of syrosingopine on the acetylcholine content in albino rats. |
| PubMed:The effect of syrosingopine on spontaneous EEG and EEG arousal induced by external stimuli in rabbits. |
| PubMed:On the pharmacology of syrosingopine and reserpine. |
| PubMed:[CLINICAL EVALUATION OF METHOXYPHENOSERPINE, A SYNTHETIC DERIVATIVE OF RESERPINE]. |
| PubMed:[ROLE OF SEVERAL SEROTONIN AND CATECHOLAMINE LIBERATORS IN THE PHENOMENON OF PAIN IN THE RAT]. |
| PubMed:THE ROLE OF ENDOGENOUS NOREPINEPHRINE IN THE TOXICITY OF D-AMPHETAMINE IN AGGREGATED MICE. |
| PubMed:THE NEWER TRANQUILIZING DRUGS. |
| PubMed:[METABOLISM OF SEROTONIN. VIII. INCREASE OF THE ELIMINATION OF 5-HYDROXY-INDOLACETIC ACID IN SUBJECTS WITH BRONCHIAL ASTHMA]. |
| PubMed:[METABOLISM OF SEROTONIN. VII. ELIMINATION OF 5-HYDROXY-INDOLACETIC ACID IN SUBJECTS WITH CHRONIC COR PULMONALE AFTER ADMINISTRATION OF CARBETHYOXYSYRINGOYL METHYLRESERPATE]. |
| PubMed:[METABOLISM OF SEROTONIN. II. DEPLETING EFFECT OF RESERPINE AND CARBETHOXYSYRINGOYL METHYLRESERPATE]. |
| PubMed:[POTENTIATION OF THE METABOLIC AND HYPOTENSIVE ACTION OF CARBETHOXYSYRINGOYL METHYLRESERPATE BY PHENYLPROPYL-DIPHENYLPROPYLAMINE]. |
| PubMed:THE INCREASE IN THE TOXICITY OF YOHIMBINE INDUCED BY IMIPRAMINE AND OTHER DRUGS IN MICE. |
| PubMed:CONCENTRATION OF NOREPINEPHRINE, SEROTONIN, AND HISTAMINE, AND OF AMINE-METABOLIZING ENZYMES IN MAMMALIAN ADIPOSE TISSUE. |
| PubMed:Comparison of syrosingopine and reserpine in the treatment of ambulatory hypertensive patients. |
| PubMed:Selective potentiation of sympathomimetic amines by reserpine. syrosingopine and 2,6-xylylcholine ether bromide (TM-10) in the dog. |
| PubMed:THE CHEMISTRY AND PHARMACOLOGY OF THE RAUWOLFIA ALKALOIDS. |
| PubMed:Endocrine pharmacology of methyl reserpate derivatives. |
| PubMed:Hypotensive and collateral effects of syrosingopine, compared with reserpine. |
| PubMed:[Diverse effect of hydrochlorothiazide in relation to the hypotensive activity of reserpine, rescinnamine, syrosingopine, 1, 4-dihydrazino-phthlazine (alone or associated with reserpine), hexamethonium and guanethidine]. |
| PubMed:Influence of syrosingopine on the cardiovascular response to acute hypoxemia and exercise. |
| PubMed:Effect of reserpine and syrosingopine on the rate and contractility of the human heart. |
| PubMed:Catecholamine levels of brain and heart in mice after iproniazid, syrosingopine and 10-methoxydeserpidine. |
| PubMed:Comparative observations of reserpine and syrosingopine. |
| PubMed:Hypertension and edema in the aged. Comparison of hydrochlorothiazide and a hydrochlorothiazide-syrosingopine combination. |
| PubMed:Hydrochlorothiazide and syrosingopine in the control of hypertension. |
| PubMed:[Comparative study of the action of reserpine and of one of its esters, syrosingopine, on the genital tract and endocrine glands of the rat]. |
| PubMed:Potentiating the hypotensive effect of hydrochlorothiazide with syrosingopine. |
| PubMed:Pharmacological consequences of the selective release of peripheral norepinephrine by syrosingopine (Su 3118). |
| PubMed:Clinical evaluation of a new reserpine derivative, SU-3118 (syrosingopine). |
| PubMed:The use of syrosingopine (SU-3118) and hydralazine in ambulatory hypertensive patients. |
| PubMed:[Hypertensive action of syrosingopine after ephedrine]. |
| PubMed:Syrosingopine: a new rauwolfia preparation. |
| PubMed:NEW AND Nonofficial Drugs: syrosingopine. |
| PubMed:Reduced sedative effect of a newly synthesized reserpine derivative (syrosingopine): clinical appraisal in primary hypertension. |
| PubMed:Therapy of hypertension with orally given syrosingopine. |
| PubMed:Mechanism of action of reserpine in producing gastric haemorrhage and erosion in the mouse. |
| PubMed:Comparison of effect of reserpine and syrosingopine on gastric acid secretion. |
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3D/inchi