EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

hematein
3,4,10,6a-tetrahydroxy-7,6a-dihydroindeno[2,1-c]chroman-9-one

Supplier Sponsors

CAS Number: 475-25-2Picture of molecule3D/inchi
Other(deleted CASRN):53986-81-5
ECHA EINECS - REACH Pre-Reg:207-492-8
FDA UNII: 88Q1SYD10B
Nikkaji Web:J12.119C
Beilstein Number:093039
MDL:MFCD00036187
XlogP3-AA:-0.20 (est)
Molecular Weight:300.26684000
Formula:C16 H12 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:coloring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 250.00 °C. @ 760.00 mm Hg
Boiling Point: 753.10 °C. @ 760.00 mm Hg (est)
Flash Point: 552.00 °F. TCC ( 289.00 °C. ) (est)
logP (o/w): 0.560 (est)
Soluble in:
 water, 600 mg/L @ 20 °C (exp)
 water, 4.511e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Abbey Color
Hematine Dye
Odor: characteristic
Use: Abbey Color is the world leader in the manufacturing of hematine, which is a natural dye. Hematine is also called Hematein and is sometimes referred to as Hemateine. Abbey Color is a trusted source for the worldwide demand of hematine dye.
EMD Millipore
For experimental / research use only.
Hematein (C.I. 75290)
sds
Glentham Life Sciences
Hematein
Santa Cruz Biotechnology
For experimental / research use only.
Hematein ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Hematein for microscopy (Hist.)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
coloring agents
Recommendation for hematein usage levels up to:
 not for fragrance use.
 
Recommendation for hematein flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):475-25-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10138
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one
Chemidplus:0000475252
 
References:
 3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:475-25-2
Pubchem (cid):10138
Pubchem (sid):134973145
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
FDA Color Additive Status ListView
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 benz(b)indeno(1,2-d)pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy-
 benz[b]indeno[1,2-d]pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy-
6a,7-dihydro-3,4,6a,10-tetrahydroxybenz(b)indeno(1,2-d)pyran-9(6H)-one
6a,7-dihydro-3,4,6a,10-tetrahydroxybenz[b]indeno[1,2-d]pyran-9(6H)-one
 haematein
 hematine
 hydroxybrasilein
 hydroxybrazilein
3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one
3,4,6a,10-tetrahydroxy-6a,7-dihydrobenz(b)indeno(1,2-d)pyran-9(6H)-one
3,4,6a,10-tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one
3,4,10,6a-tetrahydroxy-7,6a-dihydroindeno[2,1-c]chroman-9-one
 

Articles:

PubMed:[Application of fluorescence probe marked by quantum dots to detect early submandibular lymph node metastasis in a nude mouse model].
PubMed:A low detection limit penicillin biosensor based on single graphene nanosheets preadsorbed with hematein/ionic liquids/penicillinase.
PubMed:[Effects of periodontal mechanical therapy with local and systemic drugs on carotid artery and serum high-sensitivity C-reactive protein in rats with chronic periodontitis associated with atherosclerosis].
PubMed:Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.
PubMed:[A comparative study on apexification using different kinds of materials in dogs].
PubMed:[The effect of modified bone morphogenetic protein-2 polylactic acid nanospheres sustained-release system on promoting mandibular defect repair].
PubMed:The hypoglycemic effect of the kelp on diabetes mellitus model induced by alloxan in rats.
PubMed:A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus.
PubMed:Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants.
PubMed:[Pulp revascularization of immature anterior teeth with apical periodontitis].
PubMed:An enzyme-free highly glucose-specific assay using self-assembled aminobenzene boronic acid upon polyelectrolytes electrospun nanofibers-mat.
PubMed:An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode.
PubMed:Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model.
PubMed:Nuclear staining with alum hematoxylin.
PubMed:Hematein chelates of unusual metal ions for tinctorial histochemistry.
PubMed:Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications.
PubMed:A special issue devoted to hematoxylin, hematein, and hemalum.
PubMed:Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
PubMed:An amperometric urea biosensor based on covalently immobilized urease on an electrode made of hyperbranched polyester functionalized gold nanoparticles.
PubMed:Urea biosensor based on amperometric pH-sensing with hematein as a pH-sensitive redox mediator.
PubMed:Negative ion electrospray mass spectrometry of neoflavonoids.
PubMed:The precise location and nature of the nerves to the male human urethra: histological and immunohistochemical studies with three-dimensional reconstruction.
PubMed:An amperometric urea biosensor based on covalent immobilization of urease onto an electrochemically prepared copolymer poly (N-3-aminopropyl pyrrole-co-pyrrole) film.
PubMed:[The uteropelvic junction in children: from the clinical problems to the morphogenetic approach].
PubMed:Anatomical histological and mesoscopic study of the adipose tissue of the orbit.
PubMed:[Organization and innervation of striated muscle fibers of the striated sphincter in the rat].
PubMed:Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice.
PubMed:Pharmacological action and therapeutic effects of glutathione on hypokinetic spermatozoa for enzymatic-dependent pathologies and correlated genetic aspects.
PubMed:Determination of ATP via the photochemical generation of hydrogen peroxide using flow injection luminol chemiluminescence detection.
PubMed:Staining of intestinal protozoa with Heidenhain's iron hematoxylin.
PubMed:Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression.
PubMed:Comparison of historic Grübler dyes with modern counterparts.
PubMed:Hematein inhibits tumor necrotic factor-alpha-induced vascular cell adhesion molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells.
PubMed:Morphometric study of the upper intercostal nerves: practical application for neurotizations in traumatic brachial plexus palsies.
PubMed:[VCS microclip anastomosis on blood vessels of less than 2 millimeters in diameter. Preliminary experimental study in the rat].
PubMed:Hematoxylin staining in quantitative DNA cytometry: an image analysis study.
PubMed:A quick-mixed aluminum hematoxylin stain.
PubMed:New investigations on hematoxylin, hematein, and hematein-aluminium complexes. II. Hematein-aluminium complexes and hemalum staining.
PubMed:New investigations on hematoxylin, hematein, and hematein-aluminium complexes. I. Spectroscopic and physico-chemical properties of hematoxylin and hematein.
PubMed:[Colo-rectal spirochetosis: is it an anatomo-pathologic entity?].
PubMed:[Edema inhibiting effect of indenochromene derivatives from natural sources].
PubMed:Localization of phospholipids in human catecholamine neurons with Baker's acid haematein.
PubMed:[Mechanisms of the inhibition of Fe2+-induced oxidation of phosphatidylcholine by polyhydroxynaphthoquinones].
PubMed:Effects of the metal salts on the staining of elastic fibers with hematein.
PubMed:Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation.
PubMed:Effect of formalin pigment removal on peroxidase-antiperoxidase immunoperoxidase technique.
PubMed:Application of current chemical concepts to metal-hematein and -brazilein stains.
PubMed:A histological assessment of the four-day subrenal capsule assay (SRCA).
PubMed:[Cellular aspects of the aging of the articular cartilage. II. Condylar cartilage with fissured surface taken from normal and arthritic knees].
PubMed:A four-day subrenal capsule assay for testing the effectiveness of anticancer drugs against human tumors.
PubMed:Studies on Papanicolaou staining. III. Quantitative investigations of orangeophilia and cyanophilia.
PubMed:Papanicolaou staining--a review.
PubMed:Chemical aspects of santalin as a histological stain.
PubMed:The effect of sexual hormones on the lipid and proteinaceous secretion of the rat preputial sebaceous gland.
PubMed:Studies on Papanicolaou staining. II. Quantitation of dye components bound to cervical cells.
PubMed:On the mechanism of Verhoeff's elastica stain: a convenient stain for myelin sheaths.
PubMed:Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry.
PubMed:Assessment of the heart by histochemical and birefringence techniques as compared with ventricular function tests.
PubMed:On elastic fibers stain with hematein and its staining mechanism.
PubMed:Histochemical studies on metachromatic mucin stain with hematein.
PubMed:[Histological application of hematein by means of Arshid's method with special reference to staining of mucosubstances, elastic fibers and collagenous fibers].
PubMed:[Hematin treatment of porphyric neuropathy].
PubMed:[Myocardium in valvular cardiopathies. Ultrastructural and histoenzymological changes. Functional correlations].
PubMed:[On the hematein staining--comparative studies with hematoxylin staining (author's transl)].
PubMed:Histochemical and structural changes in human myocardial cells after cardiopulmonary bypass.
PubMed:Thin layer chromatography of certain preformed metal complex dyes used in biological staining.
PubMed:Effects of additives on alum hematoxylin staining solutions.
PubMed:Lipid droplets in the heart interstitium: concentration and distribution.
PubMed:Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants.
PubMed:A simple assay procedure for mixtures of hematoxylin and hematein.
PubMed:Cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural implications.
PubMed:A technique combining Baker's acid hematein and Hadjioloff's hydrotropic sudan 3 stains for identification of choline-containing phospholipids within the same tissue section.
PubMed:The staining and chromium binding of rat brain tissue and of lipids in model systems subjected to Baker's acid hematein technique.
PubMed:Assaying actual hematein content of commercial hematoxylins and hemateins.
PubMed:Studies on metallochromic indicators-III Hematoxylin and hematein.
PubMed:The acid hematein stain and myocardial damage.
PubMed:[Comparative studies on phospholipid demonstration with Baker's acid hematein test and the method of Bourgeois and Hubbard].
PubMed:[Histochemical studies with the acid hematein test according to Baker on pathologically changed skin. VI. Adipose tissue tumors and fat cells in other tumors].
PubMed:[HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICAL SKIN. IV. NEVUS CELL NEVUS, PREBLASTOMATOUS MELANOSIS AND MELANOCYTE BLASTOMA].
PubMed:On the mechanism of sequence iron-hematein stains.
PubMed:The reaction of unsaturated fats with the acid hematein test.
PubMed:[HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. 3. DENDRITE CELLS OF THE EPITHELIUM].
PubMed:[HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. II. MOLLUSCUM CONTAGIOSUM, VERRUCA VULGARIS AND CONDYLOMA ACUMINATUM].
PubMed:[HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. I. NORMAL SKIN].
PubMed:A SIMPLIFIED ACID HEMATEIN TEST FOR PHOSPHOLIPIDS.
PubMed:Experimental and cytological studies of pineal cells staining with acid hematein in the rat (Rattus norvegicus).
PubMed:Acid hematein staining of uterine neoplastic tissues.
PubMed:Cytochemical studies on tumor cells. III. Two types of tumor cells as revealed by the acid hematein test.
PubMed:Cytochemical studies on tumor cells. II. Localization of phospholipids in normal and neoplastic tissues, as revealed by the acid hematein test.
 
Notes:
None found
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