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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 326.89 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 297.00 °F. TCC ( 147.20 °C. ) (est)
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| logP (o/w): | 5.166 (est) |
| Soluble in: |
| | water, 1.45 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for (S)-curcumin usage levels up to: | | | not for fragrance use.
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| Recommendation for (S)-curcumin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Refined exposure assessment for curcumin (E 100)
View page or View pdf
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Curcumin and normal functioning of joints: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :11156616 |
| National Institute of Allergy and Infectious Diseases:Data |
| 2-methyl-5-[(2S)-6-methylhept-5-en-2-yl]phenol |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5-[(1S)-1,5- | dimethyl-4-hexenyl]-2-methylphenol | | 2- | methyl-5-[(2S)-6-methylhept-5-en-2-yl]phenol | | | phenol, 5-[(1S)-1,5-dimethyl-4-hexen-1-yl]-2-methyl- | | (S)- | xanthorrhizol |
Articles:
| PubMed:Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. |
| PubMed:Chemopreventive efficacy of Aegle marmelos on murine transplantable tumors. |
| PubMed:In vitro activity of xanthorrhizol isolated from the rhizome of Javanese turmeric (Curcuma xanthorrhiza Roxb.) against Candida albicans biofilms. |
| PubMed:Xanthorrhizol induces apoptosis through ROS-mediated MAPK activation in human oral squamous cell carcinoma cells and inhibits DMBA-induced oral carcinogenesis in hamsters. |
| PubMed:Xanthorrhizol induced DNA fragmentation in HepG2 cells involving Bcl-2 family proteins. |
| PubMed:Ent-trachyloban-19-oic acid isolated from Iostephane heterophylla as a promising antibacterial agent against Streptococcus mutans biofilms. |
| PubMed:A short synthesis of bisabolane sesquiterpenes. |
| PubMed:Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide. |
| PubMed:An antimicrobial compound isolated from Cinnamomum iners leaves with activity against methicillin-resistant Staphylococcus aureus. |
| PubMed:Facile total synthesis of xanthorrhizol. |
| PubMed:Xanthorrhizol attenuates dextran sulfate sodium-induced colitis via the modulation of the expression of inflammatory genes in mice. |
| PubMed:Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species. |
| PubMed:In vitro activity of xanthorrhizol against Candida glabrata, C. guilliermondii, and C. parapsilosis biofilms. |
| PubMed:Evaluation of the antinociceptive activity and acute oral toxicity of standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza Roxb. |
| PubMed:Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. |
| PubMed:trans-Directing ability of the amide group: enabling the enantiocontrol in the synthesis of 1,1-dicarboxy cyclopropanes. Reaction development, scope, and synthetic applications. |
| PubMed:Estrogenic activity of xanthorrhizol isolated from curcuma xanthorrhiza ROXB. |
| PubMed:Kanokonyl acetate-rich Indian valerian from northwestern Himalaya. |
| PubMed:Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B. |
| PubMed:The effect of xanthorrhizol on the expression of matrix metalloproteinase-1 and type-I procollagen in ultraviolet-irradiated human skin fibroblasts. |
| PubMed:Antiproliferative property and apoptotic effect of xanthorrhizol on MDA-MB-231 breast cancer cells. |
| PubMed:Antibacterial activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. against foodborne pathogens. |
| PubMed:Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. |
| PubMed:Development and validation of a liquid chromatography method for quantification of xanthorrhizol in roots of Iostephane heterophylla (Cav.) Benth ex Hemsl. |
| PubMed:Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells. |
| PubMed:In vitro anti-Malassezia activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. |
| PubMed:Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. |
| PubMed:Xanthorrhizol exhibits antiproliferative activity on MCF-7 breast cancer cells via apoptosis induction. |
| PubMed:Effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol on the biofilm formation of Streptococcus mutans. |
| PubMed:In vitro activity of xanthorrhizol against Streptococcus mutans biofilms. |
| PubMed:Chemical composition and anti-mosquito potential of rhizome extract and volatile oil derived from Curcuma aromatica against Aedes aegypti (Diptera: Culicidae). |
| PubMed:Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. |
| PubMed:Xanthorrhizol induces apoptosis via the up-regulation of bax and p53 in HeLa cells. |
| PubMed:Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. |
| PubMed:Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice. |
| PubMed:Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model. |
| PubMed:Phosphorylation of c-Jun N-terminal Kinases (JNKs) is involved in the preventive effect of xanthorrhizol on cisplatin-induced hepatotoxicity. |
| PubMed:Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription. |
| PubMed:Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells. |
| PubMed:Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. |
| PubMed:Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens. |
| PubMed:Xanthorrhizol: a potential antibacterial agent from Curcuma xanthorrhiza against Streptococcus mutans. |
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3D/inchi