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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 641.65 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 673.00 °F. TCC ( 355.90 °C. ) (est)
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| logP (o/w): | 4.321 (est) |
| Soluble in: |
| | water, 0.9738 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for madecassic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for madecassic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :73412 |
| National Institute of Allergy and Infectious Diseases:Data |
| (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid |
| Chemidplus:0018449417 |
References:
| | (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 73412 |
| Pubchem (sid): | 135033173 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | brahmic acid | | (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11- | trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid | | | urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)- |
Articles:
| PubMed:Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. |
| PubMed:[Studies on fingerprints of Centella asiatica by HPLC]. |
| PubMed:Two new triterpene glycosides from Centella asiatica. |
| PubMed:Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation. |
| PubMed:Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma. |
| PubMed:Centella asiatica in dermatology: an overview. |
| PubMed:Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. |
| PubMed:[Simultaneous determination of madecassoside,asiaticoside and their aglycones in Centella asiatica (L.) urban extracts by RP-HPLC]. |
| PubMed:Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs. |
| PubMed:Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials. |
| PubMed:Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts. |
| PubMed:Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. |
| PubMed:Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice. |
| PubMed:[Studies on fingerprints of Centella asiatica by HPLC]. |
| PubMed:Triterpene composition and bioactivities of Centella asiatica. |
| PubMed:Two new triterpene glycosides from Centella asiatica. |
| PubMed:Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. |
| PubMed:Conversion of alpha-amyrin into centellosides by plant cell cultures of Centella asiatica. |
| PubMed:Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. |
| PubMed:An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE). |
| PubMed:Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica. |
| PubMed:Association (micellization) and partitioning of aglycon triterpenoids. |
| PubMed:Incorporation of triterpenic derivatives within an o/w/o multiple emulsion: structure and release studies. |
| PubMed:Molecular dynamics simulation and thermodynamic modeling of the self-assembly of the triterpenoids asiatic acid and madecassic acid in aqueous solution. |
| PubMed:[Separation and determination of madecassic acid in triterpenic genins of Centella asiatica by high performance liquid chromatography using beta-cyclodextrin as mobile phase additive]. |
| PubMed:Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry. |
| PubMed:Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica. |
| PubMed:Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. |
| PubMed:An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products. |
| PubMed:Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. |
| PubMed:New innovations in scar management. |
| PubMed:Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice. |
| PubMed:Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. |
| PubMed:Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) urban. |
| PubMed:Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. |
| PubMed:Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. |
| PubMed:Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. |
| PubMed:Contact dermatitis due to madecassol. |
| PubMed:The metabolism of asiatic acid,-madecassic acid and asiaticoside in the rat. |
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3D/inchi