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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 527.88 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 418.00 °F. TCC ( 214.20 °C. ) (est)
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| logP (o/w): | 2.311 (est) |
| Soluble in: |
| | water, 340.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for urolithin A usage levels up to: | | | not for fragrance use.
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| Recommendation for urolithin A flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 6H- | dibenzo(b,d)pyran-6-one, 3,8-dihydroxy- | | 6H- | dibenzo[b,d]pyran-6-one, 3,8-dihydroxy- | | 3,8- | dihydroxy-6H-benzo[c]chromen-6-one | | 3,8- | dihydroxy-6H-dibenzo(b,d)pyran-6-one | | 3,8- | dihydroxybenzo[c]chromen-6-one |
Articles:
| PubMed:Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans. |
| PubMed:Gastrointestinal stability of urolithins: an in vitro approach. |
| PubMed:Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome. |
| PubMed:Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid. |
| PubMed:Effect of daily intake of pomegranate juice on fecal microbiota and feces metabolites from healthy volunteers. |
| PubMed:Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages. |
| PubMed:Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. |
| PubMed:Urolithin A causes p21 up-regulation in prostate cancer cells. |
| PubMed:In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. |
| PubMed:Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells. |
| PubMed:Preparative isolation and purification of urolithins from the intestinal metabolites of pomegranate ellagitannins by high-speed counter-current chromatography. |
| PubMed:The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells. |
| PubMed:Chemical composition of defatted strawberry and raspberry seeds and the effect of these dietary ingredients on polyphenol metabolites, intestinal function, and selected serum parameters in rats. |
| PubMed:Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species. |
| PubMed:Consumption of strawberries on a daily basis increases the non-urate 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity of fasting plasma in healthy subjects. |
| PubMed:Influence of gut microbiota-derived ellagitannins' metabolites urolithins on pro-inflammatory activities of human neutrophils. |
| PubMed:Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. |
| PubMed:Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. |
| PubMed:Addition of strawberries to the usual diet decreases resting chemiluminescence of fasting blood in healthy subjects-possible health-promoting effect of these fruits consumption. |
| PubMed:Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. |
| PubMed:Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients. |
| PubMed:Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals. |
| PubMed:Urolithins display both antioxidant and pro-oxidant activities depending on assay system and conditions. |
| PubMed:A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy. |
| PubMed:Time course production of urolithins from ellagic acid by human gut microbiota. |
| PubMed:Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints. |
| PubMed:In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. |
| PubMed:Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis. |
| PubMed:The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP). |
| PubMed:Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells. |
| PubMed:Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts. |
| PubMed:Metabolism of oak leaf ellagitannins and urolithin production in beef cattle. |
| PubMed:Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans. |
| PubMed:Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors. |
| PubMed:In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. |
| PubMed:The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. |
| PubMed:Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. |
| PubMed:Strawberry consumption is associated with increased antioxidant capacity in serum. |
| PubMed:Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. |
| PubMed:Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. |
| PubMed:Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. |
| PubMed:Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. |
| PubMed:Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay. |
| PubMed:Interaction of polyphenolic metabolites with human serum albumin: a circular dichroism study. |
| PubMed:Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. |
| PubMed:Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1. |
| PubMed:Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. |
| PubMed:Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. |
| PubMed:Safety evaluation of an oak-flavored milk powder containing ellagitannins upon oral administration in the rat. |
| PubMed:Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. |
| PubMed:Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. |
| PubMed:Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. |
| PubMed:Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. |
| PubMed:Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities. |
| PubMed:Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds. |
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3D/inchi