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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| Soluble in: |
| | water, 3.441 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for (Z)-ajoene usage levels up to: | | | not for fragrance use.
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| Recommendation for (Z)-ajoene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (Z)-1-(prop-2-enyldisulfanyl)-3-prop-2-enylsulfinylprop-1-ene |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9881148 |
| Pubchem (sid): | 172649019 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (Z)-1-( | prop-2-enyldisulfanyl)-3-prop-2-enylsulfinylprop-1-ene |
Articles:
| PubMed:Development of garlic bioactive compounds analytical methodology based on liquid phase microextraction using response surface design. Implications for dual analysis: Cooked and biological fluids samples. |
| PubMed:Chemical composition and bioactive compounds of garlic (Allium sativum L.) as affected by pre- and post-harvest conditions: A review. |
| PubMed:The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens. |
| PubMed:The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells. |
| PubMed:Optimizing conditions for E-and Z-ajoene formation from garlic juice using response surface methodology. |
| PubMed:Applications of thin-layer chromatography in extraction and characterisation of ajoene from garlic bulbs. |
| PubMed:Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent. |
| PubMed:Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. |
| PubMed:Solid phase microextraction coupled to liquid chromatography. Analysis of organosulphur compounds avoiding artifacts formation. |
| PubMed:Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro. |
| PubMed:Transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation. |
| PubMed:Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells. |
| PubMed:Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines. |
| PubMed:Activities of Z-ajoene against tumour and viral spreading in vitro. |
| PubMed:[Characteristics of uptake, transport and efflux of Z- and E-ajoenes in Caco-2 cell monolayers in vitro]. |
| PubMed:[Z-ajoene causes cell cycle arrest at G2/M and decrease of telomerase activity in HL-60 cells]. |
| PubMed:Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. |
| PubMed:Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice. |
| PubMed:Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage. |
| PubMed:Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties. |
| PubMed:An organosulfur compound isolated from oil-macerated garlic extract, and its antimicrobial effect. |
| PubMed:Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. |
| PubMed:Antimicrobial activity of a compound isolated from an oil-macerated garlic extract. |
| PubMed:Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products. |
| PubMed:Products of Allicin Transformation: Ajoenes and Dithiins, Characterization and their Determination by HPLC*. |
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3D/inchi