EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

sodium taurocholate
taurocholic acid sodium salt

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Name:2-[4-[(3R,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonate
CAS Number: 145-42-6Picture of molecule3D/inchi
Other(deleted CASRN):130860-43-4
ECHA EINECS - REACH Pre-Reg:205-653-7
FDA UNII: M6N3TH81NO
Beilstein Number:3901620
MDL:MFCD00013050
Molecular Weight:537.69284928
Formula:C26 H44 N Na O7 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):145-42-6 ; SODIUM TAUROCHOLATE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 0.051 (est)
Soluble in:
 water, 2.731e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Sodium taurocholate 95%
BOC Sciences
For experimental / research use only.
Sodium taurocholate 98%
Odor: characteristic
Use: Sodium taurocholate is a natural compound from Animal biles.
Carbosynth
For experimental / research use only.
Sodium Taurocholate
EMD Millipore
For experimental / research use only.
Taurocholic Acid, Sodium Salt
sds
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Taurocholate ≥97%
Sigma-Aldrich
For experimental / research use only.
Sodium Taurocholate BRP, European Pharmacopoeia (EP) Reference Standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rabbit LDLo 110 mg/kg
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Zeitschrift fuer die Gesamte Experimentelle Medizin. Vol. 52, Pg. 779, 1926.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for sodium taurocholate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium taurocholate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):145-42-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2818456
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-[4-[(3R,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonate
Chemidplus:0000145426
RTECS:WX0400000 for cas# 145-42-6
 
References:
 2-[4-[(3R,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):2818456
Pubchem (sid):134974604
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB33781
FooDB:FDB011937
FDA Listing of Food Additive Status:View
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
monosodium 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)ethanesulfonate
 taurocholic acid sodium salt
2-[4-[(3R,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonate
 

Articles:

PubMed:Fucoxanthin Derivatives: Synthesis and their Chemical Properties.
PubMed:Milk Phospholipids Enhance Lymphatic Absorption of Dietary Sphingomyelin in Lymph-Cannulated Rats.
PubMed:Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats.
PubMed:Functional role of oppA encoding an oligopeptide-binding protein from Lactobacillus salivarius Ren in bile tolerance.
PubMed:Effect of substituent pattern and molecular weight of cellulose ethers on interactions with different bile salts.
PubMed:Non-selective and selective enrichment media for the recovery of Clostridium difficile from chopped beef.
PubMed:In Vitro Study of Potentially Probiotic lactic Acid Bacteria Strains Isolated From Traditional Dairy Products.
PubMed:Functional role of tlyC1 encoding a hemolysin-like protein from Bifidobacterium longum BBMN68 in bile tolerance.
PubMed:Bile acids are nutrient signaling hormones.
PubMed:Characterization, phylogenetic affiliation and probiotic properties of high cell density Lactobacillus strains recovered from silage.
PubMed:Isolation and characterization of antifungal compound from Lactobacillus plantarum KCC-10 from forage silage with potential beneficial properties.
PubMed:Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP).
PubMed:Factors affecting adhesion of lactic acid bacteria to Caco-2 cells and inhibitory effect on infection of Salmonella typhimurium.
PubMed:Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers.
PubMed:Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.
PubMed:Cj1136 is required for lipooligosaccharide biosynthesis, hyperinvasion, and chick colonization by Campylobacter jejuni.
PubMed:Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys.
PubMed:Clostridium difficile from healthy food animals: optimized isolation and prevalence.
PubMed:Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats.
PubMed:Bile salt deconjugation and cholesterol removal from media by Lactobacillus strains used as probiotics in chickens.
PubMed:Detection of Vibrio parahaemolyticus in tropical shellfish by SYBR green real-time PCR and evaluation of three enrichment media.
PubMed:Improved isolation and detection of pathogenic Vibrio parahaemolyticus from seafood using a new enrichment broth.
PubMed:In vitro evaluation of the dissolution behaviour of itraconazole in bio-relevant media.
PubMed:Review article: The function and regulation of proteins involved in bile salt biosynthesis and transport.
PubMed:Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms.
PubMed:Enhanced lutein bioavailability by lyso-phosphatidylcholine in rats.
PubMed:Phospholipids affect the intestinal absorption of carotenoids in mice.
PubMed:The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis.
PubMed:Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice.
PubMed:A physicochemical investigation of two phosphatidylcholine/bile salt interfaces: implications for lipase activation.
PubMed:Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats.
PubMed:pH-dependent interaction of fumonisin B1 with cholesterol: physicochemical and molecular modeling studies at the air-water interface.
PubMed:Lysophosphatidylcholine enhances carotenoid uptake from mixed micelles by Caco-2 human intestinal cells.
PubMed:Effect of vagotomy on acute pancreatitis in rats.
PubMed:Effect of human milk fortifier on the immunodetection and molecular mass profile of transforming growth factor-alpha.
PubMed:Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse.
PubMed:Effect of peanut oil and randomized peanut oil on cholesterol and oleic acid absorption, transport, and distribution in the lymph of the rat.
PubMed:A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine.
PubMed:Estimation of the increase in solubility of drugs as a function of bile salt concentration.
PubMed:Stability of emulsions stabilised by two physiological surfactants: L-alpha-phosphatidylcholine and sodium taurocholate.
PubMed:Studies on the mechanism of intestinal passage of the food comutagen harman, in the rabbit.
PubMed:Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion.
PubMed:Hydrolysis of pyridoxine-5'-beta-D-glucoside by a broad-specificity beta-glucosidase from mammalian tissues.
PubMed:Parenteral nutrition: short term effects on hepatic clearance of sodium taurocholate and indocyanine green.
PubMed:Effect of cholecystokinin-octapeptide on total parenteral nutrition-induced changes in hepatic bile secretion and composition in the rat.
PubMed:Postprandial release of neurotensin-like immunoreactivity and its mechanism.
PubMed:Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
PubMed:Action of ethanol on gastrin release in the dog.
PubMed:Effect of fat retention on the rachitogenic effect of rye fed to broiler chicks.
PubMed:Bile production in fasted and fed primates.
 
Notes:
the product of conjugation of cholic acid with taurine. its sodium salt is the chief ingredient of the bile of carnivorous animals. it acts as a detergent to solubilize fats for absorption and is itself absorbed. it is used as a cholagogue and cholerectic. Emulsifier in foods
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