EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isomalt
isomaltitol

Supplier Sponsors

Name:(3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol
CAS Number: 64519-82-0Picture of molecule3D/inchi
FDA UNII:S870P55O2W
MDL:MFCD00083636
XlogP3-AA:-5.20 (est)
Molecular Weight:344.31448000
Formula:C12 H24 O11
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:sweeteners, bulking agents, anticaking agents, glazing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Additive: Isomalt
GSFA Codex: Isomalt (Hydrogenated isomaltulose) (953)
DG SANTE Food Additives:isomalt
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 788.53 °C. @ 760.00 mm Hg (est)
Flash Point: 807.00 °F. TCC ( 430.70 °C. ) (est)
logP (o/w): -4.907 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, very slightly
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
 
Suppliers:
American International Chemical, LLC.
Isomalt (galenIQ™)
Anhui Haibei
isoMalt
BOC Sciences
For experimental / research use only.
Isomalt
Cargill, Inc.
Isomaltidex® isomalt
Flavor: characteristic
Isomalt polyol sweeteners have low hygroscopicity, very low cooling effect, provides bulk, texture and it provides the preservative benefits of sucrose in sugar-free and calorie-reduced products.
ECSA Chemicals
ISOMALT
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Foodchem International
isoMalt
Glentham Life Sciences
Palatinitol
Nactis Flavours
Isomalt
O'Laughlin Industries
ISOMALTOLIN
Sinofi Food Ingredients
Isomalt
Flavor: characteristic
Sugar Substitutes, Chewing Gum, Dairy Products, Confections, Candies, Baking Food, Soft Drink, Yogurt, Desserts, Alcoholic Beverages, Instant Coffee, Ice Cream, Anticaking Agent, Bulking Agent, Glazing Agent, Pharmaceutical.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
sweeteners, bulking agents, anticaking agents, glazing agents
Recommendation for isomalt usage levels up to:
 not for fragrance use.
 
Recommendation for isomalt flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3034828
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol
Chemidplus:0064519820
RTECS:LZ4394500 for cas# 64519-82-0
 
References:
 (3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3034828
Pubchem (sid):135066178
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
Golm Metabolome Database:Search
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
6-O-alpha-D-glucopyranosyl-D-glucitol mixed with 1-O-alpha-D-glucopyranosyl-D-mannitol
isomaltitol
hydrogenated isomaltulose
 palatinit
(3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol
 

Articles:

PubMed:Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial.
PubMed:Comparative dissolution study of drug and inert isomalt based core material from layered pellets.
PubMed:Impact of fillers on dissolution kinetic of fenofibrate dry foams.
PubMed:Formulation development and evaluation of metformin chewing gum with bitter taste masking.
PubMed:Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin.
PubMed:Potential intakes of total polyols based on UK usage survey data.
PubMed:Supramolecular elucidation of the quality attributes of microcrystalline cellulose and isomalt composite pellet cores.
PubMed:Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial.
PubMed:Preparation, Characterization and Stability Studies of Glassy Solid Dispersions of Indomethacin using PVP and Isomalt as carriers.
PubMed:Deformation properties of pharmaceutical excipients determined using an in-die and out-die method.
PubMed:Assessment of isomalt for colon-specific delivery and its comparison with lactulose.
PubMed:Evaluation of a sieve classification method for characterization of low-dose interactive mixtures.
PubMed:Freeze-thaw stability of duck surimi-like materials with different cryoprotectants added.
PubMed:Dissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt.
PubMed:Compaction behavior of isomalt after roll compaction.
PubMed:Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans.
PubMed:Energy evaluation of the compaction process of directly compressible isomalt.
PubMed:Frozen yogurt with added inulin and isomalt.
PubMed:A pilot human pharmacokinetic study and influence of formulation factors on orodispersible tablet incorporating meloxicam solid dispersion using factorial design.
PubMed:Evaluation of drug release from coated pellets based on isomalt, sugar, and microcrystalline cellulose inert cores.
PubMed:Evaluation of certain food additives.
PubMed:Casein phosphopeptide-amorphous calcium phosphate incorporated into sugar confections inhibits the progression of enamel subsurface lesions in situ.
PubMed:Multimodality vascular imaging phantoms: a new material for the fabrication of realistic 3D vessel geometries.
PubMed:Improved metabolic control after 12-week dietary intervention with low glycaemic isomalt in patients with type 2 diabetes mellitus.
PubMed:Acidogenic potential of "sugar-free" cough drops.
PubMed:Compaction properties of isomalt.
PubMed:Polyols as filler-binders for disintegrating tablets prepared by direct compaction.
PubMed:Isomalt production by cloning, purifying and expressing of the MDH gene from Pseudomonas fluorescens DSM 50106 in different strains of E. coli.
PubMed:Inhibitory action of palatinose and its hydrogenated derivatives on the hydrolysis of alpha-glucosylsaccharides in the small intestine.
PubMed:Effects of Isomalt on enamel de- and remineralization, a combined in vitro pH-cycling model and in situ study.
PubMed:Human rectal mucosal gene expression after consumption of digestible and non-digestible carbohydrates.
PubMed:Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers.
PubMed:Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers.
PubMed:Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects?
PubMed:Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties.
PubMed:[A new cause of false positives when analyzing expired air carbon monoxide].
PubMed:Bioavailability of hydrochlorothiazide from isomalt-based moulded tablets.
PubMed:[Use of a new sugar substitute, erithritol, in the diet therapy of type 2 diabetes patients].
PubMed:[Comparative study of postprandial glycaemia in type 2 diabetic patients after consumption of mono- and disaccharides and sweeteners].
PubMed:The comparative gastrointestinal responses of children and adults following consumption of sweets formulated with sucrose, isomalt and lycasin HBC.
PubMed:Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro.
PubMed:The comparative gastrointestinal response of young children to the ingestion of 25 g sweets containing sucrose or isomalt.
PubMed:Direct compression and moulding properties of co-extruded isomalt/drug mixtures.
PubMed:Direct compression properties of melt-extruded isomalt.
PubMed:What clients need to know about sugar replacers.
PubMed:[Effect of mixing of fine carrier particles on dry powder inhalation property of salbutamol sulfate (SS)].
PubMed:Characterization and evaluation of isomalt performance in direct compression.
PubMed:Bowel function in runners after ingestion of sweeteners.
PubMed:Separation of alditols of interest in food products by high-performance anion-exchange chromatography with pulsed amperometric detection.
PubMed:The effects of isomaltulose, isomalt, and isomaltulose-based oligomers on mineral absorption and retention.
PubMed:Laboratory studies of sweets re-formulated to improve their dental properties.
PubMed:Dose-related gastrointestinal response to the ingestion of either isomalt, lactitol or maltitol in milk chocolate.
PubMed:Variations of the enzymatic activity of the rat's gum glycolytic cycle following administration of sweeteners.
PubMed:Bitterness of sweeteners as a function of concentration.
PubMed:Digestion and absorption of sorbitol, maltitol and isomalt from the small bowel. A study in ileostomy subjects.
PubMed:Dose dependency of fermentation and the extent of renal excretion of palatinit (isomalt) in rats with respect to its energy value.
PubMed:Breath hydrogen after ingestion of the bulk sweeteners sorbitol, isomalt and sucrose in chocolate.
PubMed:Clinical caries studies with polyalcohols. A literature review.
PubMed:'Determination' of sugar alcohol and Polydextrose absorption in humans by the breath hydrogen (H2) technique: the stoichiometry of hydrogen production and the interaction between carbohydrates assessed in vivo and in vitro.
PubMed:The digestion process of the sugar alcohol isomalt in the intestinal tract of the pig. 2. Studies with administration of isomalt as a sweet.
PubMed:The digestion process of the sugar alcohol isomalt in the intestinal tract of the pig. 1. Studies with administration of isomalt in the feed.
PubMed:Efficacy of sweeteners and sugar substitutes in caries prevention.
PubMed:Comparative studies of gastrointestinal tolerance and acceptability of milk chocolate containing either sucrose, isomalt or sorbitol in healthy consumers and type II diabetics.
PubMed:Effects of conventional sucrose-based, fructose-based and isomalt-based chocolates on postprandial metabolism in non-insulin-dependent diabetics.
PubMed:[Clinical tolerance, intestinal absorption, and energy value of four sugar alcohols taken on an empty stomach].
PubMed:Analysis of Palatinit (isomalt) and its monomers in rat intestinal samples by high-performance liquid chromatography with ultraviolet detection.
PubMed:Chronic toxicity and carcinogenicity study of isomalt in rats and mice.
PubMed:Embryotoxicity/teratogenicity of isomalt in rats and rabbits.
PubMed:Multigeneration reproduction study of isomalt in rats.
PubMed:Hydrogen excretion after ingestion of five different sugar alcohols and lactulose.
PubMed:Developmental toxicity of isomalt in rats.
PubMed:[Current and future prospects concerning the prevention of dental caries].
PubMed:[Stepwise study procedure of sugar substitutes--preliminary study with enzymes. 4. Glucosyltransferases of Streptococcus mutans AHT].
PubMed:Relationship between carbohydrate sweeteners and oral diseases.
PubMed:[Dose dependence of the energy utilization of sugar substitutes].
PubMed:Sugar substitutes and their energy value for the human body.
PubMed:[Energy utilization of Palatinit].
PubMed:[Sugar substitutes--new substances].
PubMed:Hydrolysis of lactitol, maltitol and Palatinit by human intestinal biopsies.
PubMed:On the occurrence of free glucose in the caecal contents of rats.
PubMed:Microcalorimetric investigation into the metabolic activity of rat caecal flora in the presence of different sugars and sugar substitutes.
PubMed:[Utilization of the sugar substitute Palatinit in metabolism].
PubMed:Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture, Palatinit.
PubMed:Sweeteners and dental health.
PubMed:Microbiological aspects of some caloric sugar substitutes.
PubMed:The effect of sweeteners on acid production in plaque.
PubMed:Comparative study of isomalt and sucrose by means of continuous indirect calorimetry.
PubMed:[Palatinit--digestibility and energy utilization in model experiments with sows].
PubMed:Bioavailability of glucose from Palatinit.
PubMed:[Energy metabolism and insulin activity in rats after Palatinit administration].
PubMed:[Palatinite in type II diabetics. Effect on blood-glucose, serum-insulin, C-peptide and free fatty acids].
PubMed:[Energetic utilization of Palatinit].
PubMed:[Anaerobic transformation of Palatinit by microorganisms of the human oral cavity].
PubMed:[Palatinit and xylitol in a gnotobiotic rat experiment].
PubMed:[Sweetening agent, Palatinit under specific consideration as to microbiological and caries-prophylactic aspects].
PubMed:[Studies on cariogenicity of sugar substitutes in xerostomized rats].
PubMed:[Analytical characterization of palatinit (author's transl)].
PubMed:[Palatinite--a new sugar substitute and its caries prophylactic evaluation].
 
Notes:
None found
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