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Category:nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 546.00 to 547.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 393.00 °F. TCC ( 200.40 °C. ) (est)
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| logP (o/w): | 10.305 (est) |
| Soluble in: |
| | water, 1.482e-007 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
subcutaneous-mouse LD50 700 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | nutrient supplements |
| Recommendation for vitamin K usage levels up to: | | | not for fragrance use.
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| Recommendation for vitamin K flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin K
View page or View pdf
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Dietary reference values for vitamin K
View page or View pdf
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Safety and efficacy of an additive consisting of synthetic vitamin K (phytomenadione) for horses (JARAZ Enterprises GmbH & Co. KG)
View page or View pdf
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| EPI System: View |
| ClinicalTrials.gov:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):12001-79-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :4812 |
| National Institute of Allergy and Infectious Diseases:Data |
| methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione |
| Chemidplus:0012001795 |
References:
| | methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 4812 |
| Pubchem (sid): | 135263933 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | HMDB03555 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•phytonadione, usp (vit k1, aquamephyton, konakion, mephyton)marketed in 5-mg tablets, & in ampuls containing emulsion of 2 or 10 mgml of phytonadione dispersed in soln of buffered polysorbate & propylene glycol (konakion) or polyethylated fatty acid deriv & dextrose (aquamephyton).
•konakion is admin only im; aquamephyton may be given by any parenteral route.
•colloidal soln is marketed under name aqua-mephyton.
•oral tablets; 5 mg, mephyton (scored) merck.
•phylloquinone is available as a 5 and 10 mg tablet (chewable), a 2 and 10 mgml injection solution, a 10 and 20 mgml oral solution, and a 20 mgml emulsion. phylloquinone is also available as a component (200 ug) of a multivitamin lyophilized, sterile powder intended for reconstitution and dilution in intravenous infusions, as a component (0.075 mg) of and effervescent multivitamin tablet, and as a component (5.5 ug) of a multivitamin infant formula.
•parenteral injection; 2 mgml, aquamephyton (with polyoxyethylated fatty acid derivative, dextrone, and benzyl alcohol 0.9%), merck. 10 mgml, aquamephyton (with polyoxyethylated fatty acid derivative, dextrose, and benzyl alcohol 0.9%), merck.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone | | 2- | methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione | | 2- | methyl-3-phythyl-1,4-naphthochinon | | 1,4- | naphthoquinone, 2-methyl-3-phytyl- |
Articles:
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