| Name: | (3R,3aS,9aS,9bS)-3,6,9-trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione |
| CAS Number: | 5956-04-7 |  3D/inchi
|
| FDA UNII: | Search |
| Nikkaji Web: | J15.250A |
| XlogP3-AA: | 1.60 (est) |
| Molecular Weight: | 246.30606000 |
| Formula: | C15 H18 O3 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 626.3 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for achillin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for achillin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :442139 |
| National Institute of Allergy and Infectious Diseases:Data |
| (3R,3aS,9aS,9bS)-3,6,9-trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione |
| Chemidplus:0005956047 |
References:
| | (3R,3aS,9aS,9bS)-3,6,9-trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 442139 |
| Pubchem (cas): | 5956-04-7 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | azuleno[4,5-b]furan-2,7-dione, 3,3a,4,5,9a,9b-hexahydro-3,6,9-trimethyl-, (3R,3aS,9aS,9bS)- | | | azuleno[4,5-b]furan-2,7-dione, 3,3a,4,5,9a,9b-hexahydro-3,6,9-trimethyl-, [3R-(3a,3aβ,9aβ,9ba)]- | | | guaia-1(10),3-dien-12-oic acid, 6a-hydroxy-2-oxo-, gamma-lactone, (11R)- | | (3R,3aS,9aS,9bS)-3,6,9- | trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione | | 3,6,9- | trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione-, (3R,3aS,9aS,9bS)- |
Articles:
| PubMed:Achillin Increases Chemosensitivity to Paclitaxel, Overcoming Resistance and Enhancing Apoptosis in Human Hepatocellular Carcinoma Cell Line Resistant to Paclitaxel (Hep3B/PTX) |
| PubMed:Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening |
| PubMed:Tracheal relaxation through calcium channel blockade of Achillea millefolium hexanic extract and its main bioactive compounds |
| PubMed:TLC and HPLC characteristics of desacetylmatricarin, leucodin, achillin and their 8alpha-angeloxy-derivatives |
| PubMed:Guaianolides and volatile compounds in chamomile tea |
| PubMed:Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents |
| PubMed:Inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by Artemisia capillaris |
| PubMed:Effect of guaianolides in the meiosis reinitiation of amphibian oocytes |
| PubMed:Sesquiterpenes and flavonoid aglycones from a Hungarian taxon of the Achillea millefolium group |
| PubMed:New cytotoxic sesquiterpene lactones from Anthemis scrobicularis |
| PubMed:The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation |
| PubMed:Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in |
| PubMed:[Sesquiterpenelactones of Achillea setacea with antiphlogistic activity] |
| PubMed:Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum |
| PubMed:Scopoletin: an inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei |
| PubMed:Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death |
|