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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 376.87 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 289.00 °F. TCC ( 142.60 °C. ) (est)
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| logP (o/w): | 2.978 (est) |
| Soluble in: |
| | water, 416.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 2-hydroxyflavanone usage levels up to: | | | not for fragrance use.
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| Recommendation for 2-hydroxyflavanone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2,3-dihydro-2-(2-hydroxyphenyl)- | | 2-(2- | hydroxy-phenyl)-chroman-4-one | | 2'- | hydroxyflavanone | | 2'- | hydroxyflavone | | 2-(2- | hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one | | 2-(2- | hydroxyphenyl)-2,3-dihydrochromen-4-one | | 2-(2- | hydroxyphenyl)chroman-4-one |
Articles:
| PubMed:Purification, molecular cloning and functional characterization of flavonoid C-glucosyltransferases from Fagopyrum esculentum M. (buckwheat) cotyledon. |
| PubMed:2'-hydroxyflavanone inhibits prostate tumor growth through inactivation of AKT/STAT3 signaling and induction of cell apoptosis. |
| PubMed:Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity. |
| PubMed:Cytochrome P450 93G1 Is a Flavone Synthase II That Channels Flavanones to the Biosynthesis of Tricin O-Linked Conjugates in Rice. |
| PubMed:Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3. |
| PubMed:2'-hydroxyflavanone induces apoptosis of human osteosarcoma 143 B cells by activating the extrinsic TRAIL- and intrinsic mitochondria-mediated pathways. |
| PubMed:[Inhibitory effect of 2'-hydroxyflavanone on proliferation, invasion and migration of bladder cancer cells in vitro via blocking AKT/STAT3 signaling pathway]. |
| PubMed:Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. |
| PubMed:Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone. |
| PubMed:The influence of β-cyclodextrin encapsulation on the binding of 2'-hydroxyflavanone with calf thymus DNA. |
| PubMed:Evaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography. |
| PubMed:2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells. |
| PubMed:Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. |
| PubMed:2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma. |
| PubMed:CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice. |
| PubMed:Optical isomer separation of flavanones and flavanone glycosides by nano-liquid chromatography using a phenyl-carbamate-propyl-beta-cyclodextrin chiral stationary phase. |
| PubMed:The C-glycosylation of flavonoids in cereals. |
| PubMed:AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. |
| PubMed:Chiral separation of hydroxyflavanones in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors. |
| PubMed:[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. |
| PubMed:Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. |
| PubMed:A new 2-hydroxyflavanone from Mosla soochouensis. |
| PubMed:Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. |
| PubMed:A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity. |
| PubMed:A novel 2-hydroxyflavanone from collinsonia canadensis |
| PubMed:Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food. |
| PubMed:Purification and characterization of flavone synthase I, a 2-oxoglutarate-dependent desaturase. |
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3D/inchi