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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white microcrystalline powder (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 38.10 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | 255.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.008650 mmHg @ 25.00 °C. (est) |
| Flash Point: | 186.00 °F. TCC ( 85.60 °C. ) (est)
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| logP (o/w): | 1.054 (est) |
| Soluble in: |
| | water, 7.148e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-cat LDLo 75 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926.
intravenous-dog LDLo 70 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926.
parenteral-frog LDLo 530 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926.
intravenous-human TDLo 1 mg/kg
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 120, Pg. 189, 1927.
intraperitoneal-mouse LD50 270 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
BEHAVIORAL: STRAUB TAIL
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Toxicology and Applied Pharmacology. Vol. 15, Pg. 304, 1969.
oral-mouse LD50 812 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
National Toxicology Program Technical Report Series. Vol. NTP-TR-307, Pg. 1986
intravenous-rabbit LD50 73 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948.
oral-rabbit LD50 825 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948.
intramuscular-rabbit LDLo 340 mg/kg
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926.
intraperitoneal-rabbit LDLo 310 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926.
intravenous-rat LD50 102 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948.
oral-rat LD50 404 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948.
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| Dermal Toxicity: |
subcutaneous-guinea pig LDLo 425 mg/kg
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926.
subcutaneous-rabbit LD50 383 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948.
subcutaneous-rat LD50 318 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for ephedrine sulfate usage levels up to: | | | not for fragrance use.
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| Recommendation for ephedrine sulfate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzenemethanol, a-((1S)-1-(methylamino)ethyl)-, (aR)-,sulfate (2:1) (salt) | | | benzenemethanol, a-(1-(methylamino)ethyl)-, (theta-(theta,S))-, sulfate (2:1) (salt) | | | benzenemethanol, a-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt) | | | benzenemethanol, a-[(1S)-1-(methylamino)ethyl]-, (aR)-, sulfate (2:1) (salt) | | (-)- | ephedrine sulfate | | (-)- | ephedrine sulphate | | iso | fedrol | | bis((R-(R*,S*))-b- | hydroxy-a-methylphenethyl)methylammonium sulfate | | bis((R-(R*,S*))-beta- | hydroxy-alpha-methyl phenethyl)methyl ammonium) sulfate | | (1R,2S)-2- | methylamino-1-phenylpropan-1-ol; sulfuric acid | | (1R,2S)-2-( | methylamino)-1-phenyl-1-propanol sulfate (2:1) | | (1R,2S)-2-( | methylamino)-1-phenylpropan-1-ol sulfate (2:1) | | (aR)-a-((1S)-1-( | methylamino)ethyl)benzenemethanol sulfate (2:1) (salt) | | 1-a-(1-( | methylamino)ethyl)benzyl alcohol sulfate | | | pazo ointment | | | pazo suppositories | | 1- | phenyl-2-(methylamino)propanol sulfate | | 1- | phenyl-2-methylamine-propanol-1-sulfate | | (1R,2S)-1- | phenyl-2-methylaminopropanol-1 sulfate |
Articles:
| PubMed:Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis. |
| PubMed:Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule. |
| PubMed:Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. |
| PubMed:Separation of cold medicine ingredients using a precise MEKC method at elevated pH. |
| PubMed:Comparison of the acute pharmacodynamic responses after single doses of ephedrine or sibutramine in healthy, overweight volunteers. |
| PubMed:Stability of Ephedrine Sulfate at Ambient Temperature and 4 deg C in Polypropylene Syringes. |
| PubMed:Ephedrine-activated physiological sexual arousal in women. |
| PubMed:Neurochemical mechanisms of nitroglycerin-induced neuronal activation in rat brain: a pharmacological investigation. |
| PubMed:Prevention of maternal hypotension by epidural administration of ephedrine sulfate during lumbar epidural anesthesia for cesarean section. |
| PubMed:Determination of ephedrine, pseudoephedrine, and norephedrine in mixtures (bulk and dosage forms) by proton nuclear magnetic resonance spectroscopy. |
| PubMed:Atropine and ephedrine adsorption to syringe plastic. |
| PubMed:Retrograde ejaculation and loss of emission: possibilities of conservative treatment. |
| PubMed:Nonprescription drugs and hypertension. Which ones affect blood pressure? |
| PubMed:NTP Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CAS No. 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies). |
| PubMed:Prophylaxis against repeated radiocontrast media reactions in 857 cases. Adverse experience with cimetidine and safety of beta-adrenergic antagonists. |
| PubMed:Acute angle-closure glaucoma associated with surgical anesthesia. |
| PubMed:Central nervous system lesion causing urethral instability and urinary incontinence. |
| PubMed:Experience with the classification, diagnosis, and therapy of nonejaculatory intercourse. |
| PubMed:Prophylactic intravenous ephedrine infusion during spinal anesthesia for cesarean section. |
| PubMed:Experimental motion sickness: efficacy of transdermal scopolamine plus ephedrine. |
| PubMed:The alpha-adrenergic blocking action of prazosin hydrochloride on the canine urethra. |
| PubMed:On-calcium periodate reaction method for analysis of ephedrine sulfate in solid dosage forms: collaborative study. |
| PubMed:Arrhythmogenic effects of orally administered bronchodilators. |
| PubMed:A comparative study of bronchodilator effects of carbuterol and ephedrine. |
| PubMed:Physical properties and dissolution profiles of ephedrine sulfate and nicotinic acid tablets made from water soluble vehicles. |
| PubMed:[Reaction kinetic studies on the formation of n-nitrosoephedrine in vitro and in vivo (author's transl)]. |
| PubMed:Double-blind trial of oral carbuterol in bronchial asthma. |
| PubMed:Ephedrine therapy in asthmatic children. Clinical tolerance and absence of side effects. |
| PubMed:Subject expectancy and environmental factors as determinants of psychedelic flashback experiences. |
| PubMed:Human assay of antimotion sickness drugs. |
| PubMed:Collaborative study of an on-column periodate reaction method for the determination of ephedrine sulfate in sirups. |
| PubMed:Ephedrine in treatment of urinary incontinence. |
| PubMed:Cholinergic and adrenergic neuroreceptors in urinary tract of female dogs. Evaluation of function with pharmacodynamics. |
| PubMed:Subsensitivity to epinephrine following the administration of epinephrine and ephedrine to normal individuals. |
| PubMed:Urinary excretion of ephedrine in man without pH control following oral administration of three commercial ephedrine sulfate preparations. |
| PubMed:A note on the quantitative determination of ephedrine sulfate when compounded with phenobarbital elixir U.S.P. |
| PubMed:Failure to produce polycythemia in man, dog and rabbit by daily administration of ephedrine sulfate. |
| PubMed:A comparative study of intrathecal ephedrine sulfate, intrathecal pontocaine, and inhalation anesthesia for obstetrical delivery. |
| PubMed:Prolonged spinal anesthesia using ephedrine sulfate intrathecally. |
| PubMed:The use of ephedrine sulfate in the control of enuresis in schizophrenic regression. |
| PubMed:The Spinal Anaesthetic Effects of Ephedrine Sulfate: A Preliminary Report. |
| PubMed:Influence of ephedrine sulfate on blood pressure in hypertensive rats. |
| PubMed:EPHEDRINE sulfate and phenobarbital capsules. |
| PubMed:Influence of ephedrine sulfate on blood pressure in hypertensive rats. |
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3D/inchi