EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tolnaftate
carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester

Supplier Sponsors

Name:O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
CAS Number: 2398-96-1Picture of molecule3D/inchi
Other(deleted CASRN):94256-64-1
ECHA EINECS - REACH Pre-Reg:219-266-6
FDA UNII: 06KB629TKV
Nikkaji Web:J4.423G
Beilstein Number:2752620
MDL:MFCD00056611
XlogP3-AA:5.50 (est)
Molecular Weight:307.41569000
Formula:C19 H17 N O S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 111.00 °C. @ 760.00 mm Hg
Boiling Point: 453.38 °C. @ 760.00 mm Hg (est)
Flash Point: 442.00 °F. TCC ( 228.00 °C. ) (est)
logP (o/w): 5.142 (est)
Soluble in:
 water, 0.1212 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
 
Suppliers:
American International Chemical, LLC.
TOLNAFTATE USP
BOC Sciences
For experimental / research use only.
Tolnaflate >98%
Odor: characteristic
Use: Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm.
Glentham Life Sciences
Tolnaftate
Sigma-Aldrich
For experimental / research use only.
Tolnaftate pharmaceutical secondary standard; traceable to USP, PhEur
TCI AMERICA
For experimental / research use only.
Tolnaftate >97.0%(HPLC)(N)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 6000 mg/kg
Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.

oral-dog LD50 > 14000 mg/kg
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 615, 1964.

oral-guinea pig LD50 > 4000 mg/kg
Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.

intraperitoneal-mouse LD50 120 mg/kg
Drug and Chemical Toxicology. Vol. 13, Pg. 195, 1990.

intravenous-mouse LD50 4800 mg/kg
Drugs in Japan Vol. 6, Pg. 530, 1982.

oral-mouse LD50 10000 mg/kg
Drugs in Japan Vol. 6, Pg. 530, 1982.

intravenous-rabbit LD > 50 mg/kg
Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.

Dermal Toxicity:
subcutaneous-mouse LD50 > 6000 mg/kg
Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.

subcutaneous-rat LD50 > 4000 mg/kg
Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antimicrobial agents
Recommendation for tolnaftate usage levels up to:
 not for fragrance use.
 
Recommendation for tolnaftate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):2398-96-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5510
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
Chemidplus:0002398961
EPA/NOAA CAMEO:hazardous materials
 
References:
 O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:2398-96-1
Pubchem (cid):5510
Pubchem (sid):134982225
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D00381
HMDB (The Human Metabolome Database):HMDB05005
FooDB:FDB023578
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 aftate
 carbamothioic acid, methyl (3-methylphenyl)-, O-2-naphthalenyl ester
 carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester
 chinofungin
 chlorisept
 curatin
N,N-dimethylthiocarbanilic acid O-2-naphthyl ester
 dungistop
 focusan
 fungistop
 genaspor
 hi-alarzin
 methyl (3-methyl phenyl) carbamothioic acid ortho-2-naphthalenyl ester
 methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
 methyl 3-tolylthiocarbamic acid O-naphthalen-2-yl ester
N-methyl-(3-methylphenyl)-carbamothioic acid, O-2-naphthalenyl ester
 methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester
[methyl(3-methylphenyl)amino]-2-naphthyloxymethane-1-thione
 methyl(3-methylphenyl)carbamothioic acid O-2-Naphthalenyl Ester
 micoisdin
O-naphthalen-2-yl methyl(3-methylphenyl)carbamothioate
O-naphthalen-2-yl methyl(m-tolyl)carbamothioate
O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
 naphthiomate T
 naphthiomate-T
2-naphthyl (3-dimethylanilino)methanethioate
O-2-naphthyl m,N-dimethylthiocarbanilate
O-2-naphthyl methyl(3-methylphenyl)carbamothioate
O-2-naphthyl methyl(3-methylphenyl)thiocarbamate
2-naphthyl N-methyl-N-(3-tolyl) thionocarbamate
2-naphthyl N-methyl-N-(3-tolyl)thionocarbamate
o-(2-naphthyl) methyl(3-methylphenyl)thiocarbamate
 ony clear
 ony-clear
 phytoderm
 pitrex
 separin
 sporiline
 timoped
 tinactin
 tinaderm
 tinatox
 tinavet
 tineafax
 tniaderm
 tolnaftat Purder N
 tolnaftate USP
 tolnaftatum
 tolnaphthate
 tolsanil
 tonoftal
 zeasorb
 

Articles:

PubMed:Studying the penetration of fatty acids into human skin by ex vivo TOF-SIMS imaging.
PubMed:Characterization of iprodione resistance in Botrytis cinerea from strawberry and blackberry.
PubMed:Detailed study of precipitation of a poorly water soluble test compound using methodologies as in activity and solubility screening - mixing and automation effects.
PubMed:A study to evaluate the price control of antifungal medicines and its practical applicability.
PubMed:A randomised controlled trial of active chronic otitis media comparing courses of eardrops versus one-off topical treatments suitable for primary, secondary and tertiary healthcare settings.
PubMed:Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo.
PubMed:Nonplanar property study of antifungal agent tolnaftate-spectroscopic approach.
PubMed:Assay of tolnaftate in human skin samples after in vitro penetration studies using high performance liquid chromatography.
PubMed:Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.
PubMed:Current concepts in systemic and topical therapy for superficial mycoses.
PubMed:Otomycosis: Diagnosis and treatment.
PubMed:Label-free detection of drug-membrane association using ultraviolet-visible sum-frequency generation.
PubMed:Highly sensitive and selective spectrofluorimetric determination of tolnaftate through the formation of ternary inclusion complex of beta-naphthol/beta-cyclodextrin/anionic surfactant system.
PubMed:Are placebo-controlled trials of creams for athlete's foot still justified?
PubMed:Ototopical antifungals and otomycosis: a review.
PubMed:Topical treatments for fungal infections of the skin and nails of the foot.
PubMed:[Use of topical antifungal agents].
PubMed:Study on the supramolecular multirecognition mechanism of beta-naphthol/beta-cyclodextrin/anionic surfactant in a tolnaftate hydrolysis system.
PubMed:Trichophyton rubrum isolated from aids and human immunodeficiency virus-infected patients in São Paulo, Brazil: antifungal susceptibility and extracellular enzyme production.
PubMed:Biochemical characterization of terbinafine-resistant Trichophyton rubrum isolates.
PubMed:[Antimycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis].
PubMed:Validation of a liquid chromatography assay for the quantification of the Raf kinase inhibitor BAY 43-9006 in small volumes of mouse serum.
PubMed:Tolnaftate spray treatment during pregnancy.
PubMed:Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay.
PubMed:A study of dermatophytes and their in-vitro antifungal sensitivity.
PubMed:Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects.
PubMed:Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine.
PubMed:X-ray powder diffractometric method for quantitation of crystalline drug in microparticulate systems. I. Microspheres.
PubMed:Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis.
PubMed:LC of pharmaceutically important halogenated 8-hydroxyquinolines after precolumn derivatization with Pd (II).
PubMed:[Therapeutic efficacy of a topical tolnaftate preparation in guinea pig model of tinea pedis].
PubMed:Assay of tolnaftate and related impurities by isocratic supercritical fluid chromatography.
PubMed:Topical treatments for fungal infections of the skin and nails of the foot.
PubMed:Ototoxicity of common topical antimycotic preparations.
PubMed:Analysis of some antifungal drugs by spectrophotometric and spectrofluorimetric methods in different pharmaceutical dosage forms.
PubMed:Synthesis and in vitro antifungal activity of some N,N-disubstituted dithiocarbamic acid esters derived from 2-methylquinazolinones.
PubMed:Systematic review of topical treatments for fungal infections of the skin and nails of the feet.
PubMed:Enhancing effect of N-acetyl-l-cysteine or 2-mercaptoethanol on the in vitro permeation of 5-fluorouracil or tolnaftate through the human nail plate.
PubMed:Butenafine.
PubMed:In-vitro permeability of the human nail and of a keratin membrane from bovine hooves: prediction of the penetration rate of antimycotics through the nail plate and their efficacy.
PubMed:[Mycetomas caused by Microsporum canis. Report of one case].
PubMed:[The photostability of antimycotics. 3. Photostability of locally acting antimycotics].
PubMed:Determination of the physical state of drug in microcapsule and microsphere formulations.
PubMed:Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents.
PubMed:Allergic contact dermatitis from tolnaftate.
PubMed:Ergosterol biosynthesis inhibition: a target for antifungal agents.
PubMed:Current therapy of dermatophytosis.
PubMed:Characterization of a novel antimycotic agent, cinnamyl benzoate, using yeast-phase Sporothrix schenckii.
PubMed:A liquid chromatographic method for the determination of tolnaftate in pharmaceutical formulations.
PubMed:Effects of antimycotics on the biosynthesis of cellular macromolecules in Aspergillus niger protoplasts.
PubMed:Spectrophotometric methods for the determination of tolnaftate.
PubMed:Two mechanisms of butenafine action in Candida albicans.
PubMed:[New antifungal agents in the treatment of superficial dermatomycoses].
PubMed:Effects of squalene epoxidase inhibitors on Candida albicans.
PubMed:Superficial fungal infections of the skin. Diagnosis and current treatment recommendations.
PubMed:Therapeutic efficacy of latoconazole in formulations of clinical use on experimental dermatophytosis in guinea pigs.
PubMed:Tea tree oil in the treatment of tinea pedis.
PubMed:Antifungal activity of the new agent latoconazole in two tinea models.
PubMed:Liquid chromatographic determination of tolnaftate in commercial products.
PubMed:Studies on the mode of action of tolnaftate in Microsporum gypseum.
PubMed:Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent.
PubMed:Epoxidation of aflatoxin B1 by Aspergillus flavus microsomes in vitro: interaction with DNA and formation of aflatoxin B1-glutathione conjugate.
PubMed:[Tolnaftate Reference Standard (Control 901) of National Institute of Hygienic Sciences].
PubMed:Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs.
PubMed:Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs.
PubMed:In vitro and in vivo activities of piritetrate (M-732), a new antidermatophytic thiocarbamate.
PubMed:In vitro sensitivity of antifungal agents.
PubMed:Ototoxicity of antimycotics.
PubMed:Clinical examinations with chinofungin spray and chinofungin powder.
PubMed:Inhibitory effect of a new mycotic agent, piritetrate on ergosterol biosynthesis in pathogenic fungi.
PubMed:Observations with Chinofungin powder.
PubMed:In vitro effectiveness of 13 agents in otomycosis and review of the literature.
PubMed:Diflucortolone valerate. Asian experience.
PubMed:Evaluation of fungicidal action in vitro and in a skin model considering the influence of penetration kinetics of various standard antimycotics.
PubMed:Use of tolnaftate powder in the treatment and prophylaxis of foot mycoses.
PubMed:Activity of terbinafine in experimental fungal infections of laboratory animals.
PubMed:A microbiological study of otomycosis in Visakhapatnam.
PubMed:Enhanced percutaneous absorption of homogenized tolnaftate/beta-cyclodextrin polymer ground mixture.
PubMed:[Use of a chinofungin aerosol in mycotic lesions of the skin].
PubMed:Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans.
PubMed:An in vitro human skin model for assaying topical drugs against dermatophytic fungi.
PubMed:In vitro activity of ME1401, a new antifungal agent.
PubMed:Tinactin in the treatment of fungal otitis externa.
PubMed:Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate.
PubMed:An in vitro method of evaluating tolnaftate release from topical powder.
PubMed:The mode of antifungal action of tolnaftate.
PubMed:Superficial mycoses. Therapeutic agents and clinical applications.
PubMed:Current treatment of dermatophytoses.
PubMed:Effects of antifungal agents on ergosterol biosynthesis in Candida albicans and Trichophyton mentagrophytes: differential inhibitory sites of naphthiomate and miconazole.
PubMed:A new combination of tolnaphtate and methylpartricine (SPA-S-345, Tritol) for mycotic skin infections.
PubMed:Prevalence of bacteria and fungi in athlete's foot of varying severity and response to topical antibacterial and antifungal therapies.
PubMed:Antifungal therapy of dermatophytosis in guinea pigs and congenitally athymic rats.
PubMed:Combined allergy to tolnaftate and nystatin.
PubMed:[Tinea caused by Microsporum canis in children under 30 days of age].
PubMed:Secondary antithyroid action of drugs in relation to structure.
PubMed:[Otomycosis].
PubMed:Favus in a fighting cock caused by Microsporum gallinae.
PubMed:[Dermatophytosis caused by Aphanoascus fulvescens].
PubMed:An experimental model for evaluation of antifungal agents in a Trichophyton mentagrophytes infection of guinea pigs.
PubMed:The treatment of dermatophytoses of the glabrous skin: a comparison of undecylenic acid and its salt versus tolnaftate.
PubMed:[Antimycotic therapy. 1: Classification, antimycotic drugs: flucytosine, tolnaftate].
PubMed:Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment.
PubMed:The "hair root invasion test", a semi-quantitative method for experimental evaluation of antimycotics in guinea-pigs.
PubMed:[New therapy of tinea unguium: ODT (occlusive dressing technic) using 20% urea ointment and an antifungal agent].
PubMed:Otomycosis: an experimental evaluation of six antimycotic agents.
PubMed:2% Miconazole nitrate powder in aerosol spray form: its efficacy in treating tinea pedis.
PubMed:[Antifungal agents].
PubMed:In vivo antimycotic activity of naftifine.
PubMed:In vitro activity of naftifine, a new antifungal agent.
PubMed:The use of Chinofungin spray in fungal dermatological diseases.
PubMed:[Selected double-blind comparative studies on the efficacy and tolerance of ciclopiroxolamine solution and cream].
PubMed:Comparative merits of two topical corticosteroid antimicrobial drugs.
PubMed:[Double blind, randomized in vivo investigations comparing the antifungals clotrimazole, tolnaftate and naftifine (author's transl)].
PubMed:Drugs for fungal infections.
PubMed:Mechanism of action of antifungal drugs, with special reference to the imidazole derivatives.
PubMed:[In vitro demonstration of the antibacterial and antimycotic efficacy of a preparation containing nystatin and chlorquinaldol compared with similar antimicrobial agents (author's transl)].
PubMed:Comparative in vitro and in vivo antifungal activity of tolnaftate and various undecylenates: a rebuttal.
PubMed:Comparative in vitro and in vivo antifungal activity of tolnaftate and various undecylenates.
PubMed:Comparison between undecylenic acid and tolnaftate in the treatment of tinea pedis.
PubMed:Specific drugs for superficial fungus infections.
PubMed:Hypertrophic scarring as a complication of fluorouracil therapy.
PubMed:Tinea pedis masking a Kaposi's sarcoma.
PubMed:Dermatophyte infections.
PubMed:[Foot mycosis - practice and proved excellence (author's transl)].
PubMed:Chronic papular dermatitis of the scrotum due to Schistosoma mansoni.
PubMed:[Piadar (Ladar): new antimycotic drug containing the antifungal agent siccanin (author's transl)].
PubMed:Comparison of over-the-counter agents for tinea pedis.
PubMed:[Our experience in the treatment of various dermatoses with a polyvalent topical drug].
PubMed:[Clinical evolution with a polyvalent topical compound].
PubMed:[Present state of antimycotic therapy (author's transl)].
PubMed:Comparison of in vitro activity of undecylenic acid and tolnaftate against athlete's foot fungi.
PubMed:[The role of ointment bases in the formulation of 2 antifungal drugs. II. Liberation studies on 5-fluorocytosine and tolnaftate ointment bases by the microbiological agar plate method].
PubMed:Topical antimycotic agents for the treatment of superficial dermatophytoses in Thailand--a double-blind study.
PubMed:Comparative in vitro & in vivo evaluation of tolciclate, tolnaftate, miconazole, clotrimazole & undecylenic acid against Trichophyton mentagrophytes.
PubMed:Interdigital athlete's foot. The interaction of dermatophytes and resident bacteria.
PubMed:Efficacy of topical miconazole treatment of tinea pedis.
PubMed:Inhibition of aflatoxin biosynthesis by tolnaftate.
PubMed:[Effect of tociclate and other modern antimycotics on dermatophytes].
PubMed:In vitro studies with ambruticin, a new antifungal antibiotic.
PubMed:[Comparative studies on Bi-Nerisona cream (diflucortolone valerinate + chlorquinaldol) and on a combination preparation (betamethasone valerinate + gentamicin + tolnaftate + clioquinol) in a double-blind trial].
PubMed:Experimental ringworm infection in guineapig for the evaluation of drugs.
PubMed:Topical agents in the treatment of superficial fungal infections.
PubMed:Factors affecting germination of Trichophyton mentagrophytes arthrospores.
PubMed:Drug-induced changes in the plasma membrane of Microsporum canis. A preliminary freeze--fracture study.
PubMed:Antifungal agents: recent developments.
PubMed:Drugs for athlete's foot and tinea cruris.
PubMed:An automated radiometric microassay of fungal growth: quantitation of growth of T. mentagrophytes.
PubMed:[Synthetic antimycotica (author's transl)].
PubMed:Superficial mycoses.
PubMed:Antibiotic sensitivity of the yeast and mycelial phases of Histoplasma capsulatum.
PubMed:New topical agents for dermatophytosis.
PubMed:Tolciclate against dermatophytes.
PubMed:[Remarkable efficacy of tolnaftate on otomycoses (30 cases)].
PubMed:Antifungal drugs.
PubMed:Miconazole in the treatment of dermatomycosis.
PubMed:[Progresses in the development of antimycotic effective substances (author's transl)].
PubMed:Evaluation of the effectiveness of griseofulvin, tolnaftate, and placebo in the topical therapy of superficial dermatophytoses.
PubMed:Topical treatment of dermatophytoses and candidoses.
PubMed:[Clinical trials in various dermatoses, with a new topical corticoid-anti-infective agent combination].
PubMed:Clotrimazole: a review of its antifungal activity and therapeutic efficacy.
PubMed:[Clinical study with Hoe 296 in glabrous skin dermatophytosis and pityriasis versicolor].
PubMed:A double-blind comparison of clotrimazole and tolnaftate therapy of superficial dermatophytoses.
PubMed:Dermatomycoses: a brief history of therapy and initial results with clotrimazole.
PubMed:Tolnaftate powder in prophylaxis of tinea pedis.
PubMed:Control of tinea pedis in a swimming bath.
PubMed:[Epidermophytoses and Candida mycoses. Treatment and prevention of recurrence].
PubMed:[Dermatophytoses. Mycoses of the skin due to dermatophytes].
PubMed:[Has tolnaftate a fungicidal effect against dermatophytes (author's transl)].
PubMed:Tinea faciale: an often misdiagnosed clinical entity.
PubMed:[Tinea nigra. Report of 16 cases].
PubMed:Human models for in vivo and in vitro assessment of topical antifungal compounds.
PubMed:Pediatric antimicrobial therapy. V.
PubMed:Haloprogin for tinea.
PubMed:Allergic contact dermatitis from tolnaftate.
PubMed:Contact urticaria.
PubMed:Tolnaftate as a prophylactic agent for tinea pedis.
PubMed:The treatment of cutaneous candidiasis in rabbits.
PubMed:[Therapy with tolnaftate in otomycosis due to Aspergillus niger].
PubMed:Clinical efficacy studies of haloprogin, a new topical antimicrobial agent.
PubMed:Haloprogin therapy for dermatophyte infections.
PubMed:Clinical evaluation of haloprogin.
PubMed:Contact allergy to tolnaftate.
PubMed:[Treatment of epidermycosis with sporilina].
PubMed:[Trichophytiasis blepharociliaris with dissemination into the right side of the face].
PubMed:Virulence of Trichophyton mentagrophytes infecting steroid-treated guinea pigs.
PubMed:A controlled study of haloprogin and tolnaftate in tinea pedis.
PubMed:Tolnaftate in the treatment of superficial mycotic infections.
PubMed:[Demonstration of the formation of a concentric inhibiting circle due to combination of nystatine and tolnaftate in a mixed culture from Trichophyton mentagrophytes and Candida tropicalis].
PubMed:Antimicrobial agents. XV. Antimycotic effect of VUFB-9244, 2-methylthio-5-(3-iodopropargyloxy)pyrimidine.
PubMed:Antifungal agents.
PubMed:[Microbiological evaluation of salicyclic acid and other broad spectrum antimicrobials].
PubMed:Chemotherapeutic evaluation of clotrimazole (Bay b 5097, 1 (o-chloro- - -diphenylbenzyl) imidazole).
PubMed:Common cutaneous manifestations and problems of diabetes mellitus.
PubMed:Prophylaxis of tinea pedis. Efficacy of tolnaftate powder and its talc-cornstarch base.
PubMed:[Colorimetric determination of naphthiomate-T (tolnaftate) in preparations].
PubMed:Electron microsopic studies of the effect of tolnaftate on Trichophyton schoenleinii.
PubMed:Haloprogin: a topical antifungal agent.
PubMed:A new antifungal agent--tolnaftate.
PubMed:"In vitro" sorption of tolnaftate by protein substrates.
PubMed:The influence of corticosteroids, griseofulvin and tolnaftate on the in vitro growth of two dermatophytes.
PubMed:'Prophylactic' activity of tolnaftate in experimental Trichophyton mentagrophytes infections of guinea pigs.
PubMed:Observations on a clinico-therapeutic trial with a new tropical fugicidal agent-Tolnaftate 1 p.c. solution: (brand name in India-Tinaderm) on superficial mycotic infections of the skin.
PubMed:[Treatment of various dermatomycoses with topical tolnaftate].
PubMed:[Our experience with antimycotic therapy with Tolnaftate].
PubMed:Erythrasma. Response to tolnaftate, an antifungal medication.
PubMed:A clinical trial of Tolnaftate in fungus infection of the skin.
PubMed:[Considerations on the treatment of certain dermatomycoses with tolnaftate].
PubMed:Tolnaftate.
PubMed:Qualitative and quantitative tests for tolnaftate.
PubMed:Clinical experiences with tolnaftate.
PubMed:In vitro activity of tolnaftate.
PubMed:Clinical trials of tolnaftate and variotin.
PubMed:Tolnaftate, its effectiveness in pedal mycosis. A preliminary report.
PubMed:Microsporum nanum. A review of the literature and a report of two cases.
PubMed:[Local treatment of dermatomycoses with tolnaftate].
PubMed:Tinea nigra. Report of two cases and results of treatment with tolnaftate.
PubMed:A topical agent for the treatment of superficial fungal infections of the skin. Tolnaftate (Tinactin).
PubMed:Teratogenesis study of tolnaftate, an antitrichophyton agent.
PubMed:Toxicologic and pharmacologic properties of tolnaftate, an antitrichophyton agent.
PubMed:Tolnaftate: a potent nonirritating topical fungicide.
PubMed:[Treatment of dermatomycoses with Tolnaftate].
PubMed:Clinical evaluation of tolnaftate. A double blind study of a topical antifungal agent.
PubMed:Clinical and comparative evaluation of "Tolnaftate" as an antifungal agent in the U.A.R.
PubMed:Tolnaftate in superficial fungus infections.
PubMed:Tolnaftate (tinactin), a new topical antifungal agent.
PubMed:[The topical treatment of tinea with tolnaftate].
PubMed:[Local therapeutic trial of tolnaftate in the control of several superficial cutaneous mycoses].
PubMed:COMPARATIVE STUDY OF TOLNAFTATE SOLUTION AND COMPOUND UNDECYLENIC ACID OINTMENT N.F. IN THE TREATMENT OF EPIDERMOPHYTOSES.
PubMed:TOLNAFTATE, A POTENT TOPICAL ANTIFUNGAL AGENT.
PubMed:Tolnaftate, a potent topical antifungal agent.
PubMed:TREATMENT OF CUTANEOUS FUNGOUS INFECTION WITH TOLNAFTATE.
PubMed:TOLNAFTATE IN DERMATOLOGY: A NEW, POTENT TOPICAL FUNGICIDE.
PubMed:TOLNAFTATE THERAPY OF MYCOTIC INFECTIONS. PRELIMINARY REPORT.
PubMed:CLINICAL INVESTIGATION OF TOLNAFTATE IN THE UNITED STATES.
PubMed:EFFECT OF TOLNAFTATE IN SUPERFICIAL FUNGUS INFECTIONS.
PubMed:EFFECT OF TOLNAFTATE ON SUPERFICIAL MYCOTIC INFECTIONS.
PubMed:DETERMINATION OF NONSENSITIZING PROPERTIES OF TOLNAFTATE SOLUTION 1 PERCENT.
PubMed:ANTIFUNGAL PROPERTIES OF TOLNAFTATE IN VITRO AND IN VIVO.
 
Notes:
a synthetic antifungal agent. Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor-Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, and Ting.and Odor-Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, and Ting. [HMDB]
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