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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 2.897 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 3'-angeloyl oxy-4'-acetoxy-3',4'-dihydroseselin usage levels up to: | | | not for fragrance use.
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| Recommendation for 3'-angeloyl oxy-4'-acetoxy-3',4'-dihydroseselin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :9821539 |
| National Institute of Allergy and Infectious Diseases:Data |
| [(9R,10R)-10-acetyloxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-f]chromen-9-yl] (Z)-2-methylbut-2-enoate |
| Chemidplus:0081740058 |
References:
| | [(9R,10R)-10-acetyloxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-f]chromen-9-yl] (Z)-2-methylbut-2-enoate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9821539 |
| Pubchem (sid): | 135302203 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 10-( | acetyl oxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3,4-b')dipyran-9-yl 2-methyl-2-butenoate | | 10-( | acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3,4-b')dipyran-9-yl 2-methyl-2-butenoate | | 3'- | angeloyloxy-4'-acetoxy-3',4'-dihydroseselin | | 2- | butenoic acid, 2-methyl-, 10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3,4-b')dipyran-9-yl ester | | | Pd-Ia | | | praeruptorin A |
Articles:
| PubMed:Design of guanidinium ionic liquid based microwave-assisted extraction for the efficient extraction of Praeruptorin A from Radix peucedani. |
| PubMed:Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. |
| PubMed:Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. |
| PubMed:¹H nuclear magnetic resonance based-metabolomic characterization of Peucedani Radix and simultaneous determination of praeruptorin A and praeruptorin B. |
| PubMed:Metabolic characterization of (±)-praeruptorin A in vitro and in vivo by high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry. |
| PubMed:Effects of praeruptorin A and praeruptorin C, a racemate isolated from Peucedanum praeruptorum, on MRP2 through the CAR pathway. |
| PubMed:Preparation and evaluation of dl-praeruptorin A microemulsion based hydrogel for dermal delivery. |
| PubMed:Regulation of human pregnane X receptor and its target gene cytochrome P450 3A by praeruptorin A isolated from the herbal medicine Peucedanum praeruptorum. |
| PubMed:Simultaneously enantiospecific determination of (+)-trans-khellactone, (+/-)-praeruptorin A, (+/-)-praeruptorin B, (+)-praeruptorin E, and their metabolites, (+/-)-cis-khellactone, in rat plasma using online solid phase extraction-chiral LC-MS/MS. |
| PubMed:Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. |
| PubMed:The effects of (±)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-β1/Smad signaling pathway in a murine model of allergic asthma. |
| PubMed:Liquid chromatography tandem mass spectrometry pharmacokinetic study of DL-praeruptorin A in rat plasma. |
| PubMed:[Induction of UGT1A1 expression by praeruptorin A and praeruptorin C through hCAR pathway]. |
| PubMed:Stereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans. |
| PubMed:Effects of (±)-praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease. |
| PubMed:(+/-)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis. |
| PubMed:Pharmacological mechanism underlying anti-inflammatory properties of two structurally divergent coumarins through the inhibition of pro-inflammatory enzymes and cytokines. |
| PubMed:Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry. |
| PubMed:Pharmacokinetics, tissue distribution and excretion study of dl-praeruptorin A of Peucedanum praeruptorum in rats by liquid chromatography tandem mass spectrometry. |
| PubMed:Praeruptorin A inhibits lipopolysaccharide-induced inflammatory response in murine macrophages through inhibition of NF-κB pathway activation. |
| PubMed:Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers. |
| PubMed:Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis. |
| PubMed:Simultaneous quantification of three pyranocoumarins of Peucedanum praeruptorum in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study. |
| PubMed:[Semi-synthesis of derivatives with C-3' and C-4' trans-configuration from (+)-praeruptorin A]. |
| PubMed:[Studies on structure modification of (+)-praeruptorin A]. |
| PubMed:[Extraction of praeruptorin A from Radix Peucedani by supercritical fluid extraction-CO2]. |
| PubMed:Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: a review. |
| PubMed:Effects of dl-praeruptorin A on cultured neonatal rat ventricular cardiomyocytes with hypertrophy induced by endothelin-1. |
| PubMed:(+/-)-3'-O, 4'-O-dicynnamoyl-cis-khellactone, a derivative of (+/-)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells. |
| PubMed:Effects of dl-praeruptorin A on nucleus factor-kappaB and tumor necrosis factor-alpha expression in ischemia-reperfusion hearts. |
| PubMed:Effect of dl-praeruptorin A on ATP sensitive potassium channels in human cortical neurons. |
| PubMed:Application of stepwise gradients in counter-current chromatography: a rapid and economical strategy for the one-step separation of eight coumarins from Seseli resinosum. |
| PubMed:Effect of dl-praeruptorin A on desmin and vimentin content in rat ischemia/reperfusion myocardiocytes. |
| PubMed:Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on cardiohemodynamics in anesthetized dogs. |
| PubMed:Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on myocardial dysfunction after a brief ischemia in anesthetized dogs. |
| PubMed:Effects of dl-praeruptorin A on interleukin-6 level and Fas, bax, bcl-2 protein expression in ischemia-reperfusion myocardium. |
| PubMed:Research progress of the studies on the roots of Peucedanum praeruptorum dunn (Peucedani radix). |
| PubMed:Effect of dl-praeruptorin A on calcium current in ventricular cells of guinea pig. |
| PubMed:Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. |
| PubMed:Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column. |
| PubMed:3'-O, 4'-O-aromatic acyl substituted 7,8-pyranocoumarins: a new class of P-glycoprotein modulators. |
| PubMed:Praeruptorin D and E attenuate lipopolysaccharide/hydrochloric acid induced acute lung injury in mice. |
| PubMed:Biological activities and pharmacokinetics of praeruptorins from Peucedanum species: a systematic review. |
| PubMed:Studies on coumarins of a chinese drug "Qian-Hu". |
| PubMed:CAR-mediated up-regulation of CYP3A4 expression in LS174T cells by Chinese herbal compounds. |
| PubMed:Chemopreventive effects of Peucedanum praeruptorum DUNN and its major constituents on SGC7901 gastric cancer cells. |
| PubMed:Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae). |
| PubMed:Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. |
| PubMed:Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators. |
| PubMed:[Simultaneous determination of three coumarin constituents in roots of Peucedanum praeruptorum by RP-HPLC]. |
| PubMed:Isolation of praeruptorins A and B from Peucedanum praeruptorum Dunn. and their general pharmacological evaluation in comparison with extracts of the drug. |
| PubMed:Structures of Angular Pyranocoumarins of Bai-Hua Qian-Hu, the Root of Peucedanum praeruptorum1. |
| PubMed:Antiinflammatory activity of coumarins from Ligusticum lucidum Mill. subsp. cuneifolium (Guss.) Tammaro (Apiaceae). |
| PubMed:[Studies on quality standard of Peucedanum praeruptorum]. |
| PubMed:Coumarins from Peucedanum wulongense. |
| PubMed:Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries. |
| PubMed:Chemical constituents of Selinum cryptotaenium. |
| PubMed:Effects of a pyranocoumarin compound isolated from a Chinese medicinal plant on ischemic myocardial dysfunction in anesthetized dogs. |
| PubMed:[The isolation and identification of qianhucoumarin B and qianhucoumarin C from Peucedanum praeruptorum]. |
| PubMed:Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone. |
| PubMed:[Isolation and structure elucidation of longshengensin A from Peucedanum longshengense]. |
| PubMed:Effects of active compounds isolated from Angelica shikokiana on lipid metabolism in fat cells. |
| PubMed:Calcium antagonist-like actions of coumarins isolated from "Qian-Hu" on anaphylactic mediator release from mast cell induced by concanavalin A. |
| PubMed:Synthesis and blood pressure lowering activity of benzylic ethers of 2-diethylaminoethanol and a related diamine. |
| PubMed:Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. |
| PubMed:Preparative isolation and purification of coumarins from Peucedanum praeruptorum Dunn by high-speed counter-current chromatography. |
| PubMed:Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum. |
| PubMed:Effects of chroman derivatives on platelet aggregation induced by some aggregating agents in rabbits. |
| PubMed:Pharmacological activities of the prenylcoumarins, developed from folk usage as a medicine of Peucedanum japonicum THUNB. |
| PubMed:Constituents of Shashen (Adenophora axilliflora). |
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3D/inchi