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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 123.00 to 124.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 504.00 to 505.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 414.00 °F. TCC ( 212.30 °C. ) (est)
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| logP (o/w): | 4.064 (est) |
| Soluble in: |
| | water, 6.555 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for (+)-sesamin usage levels up to: | | | not for fragrance use.
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| Recommendation for (+)-sesamin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :72307 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole |
| Chemidplus:0000607807 |
References:
| | 5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 72307 |
| Pubchem (sid): | 135030851 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5-[(3S,3aR,6S,6aR)-3-(1,3- | benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole | | | fagarol | | dextro-(+)- | sesamin | | epi- | sesamin | | (1S-(1alpha,3a alpha,4alpha,6a alpha))-5,5'-( | tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl) bis-5,5'-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl) |
Articles:
| PubMed:Sesamin suppresses macrophage-derived chemokine expression in human monocytes via epigenetic regulation. |
| PubMed:Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma. |
| PubMed:Combined effect of sesamin and soybean phospholipid on hepatic fatty acid metabolism in rats. |
| PubMed:Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin. |
| PubMed:Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide. |
| PubMed:Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense. |
| PubMed:Sesamin and sesamolin as unexpected contaminants in various cold-pressed plant oils: NP-HPLC/FLD/DAD and RP-UPLC-ESI/MS(n) study. |
| PubMed:α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro. |
| PubMed:Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway. |
| PubMed:¹H NMR-based metabolomics studies on the effect of sesamin in Atlantic salmon (Salmo salar). |
| PubMed:[Isolation and identification of impurities in the natural vitamin E]. |
| PubMed:Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae). |
| PubMed:Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage. |
| PubMed:Sesamin modulation of lipid class and fatty acid profile in early juvenile teleost, Lates calcarifer, fed different dietary oils. |
| PubMed:Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway. |
| PubMed:Sesamin extends the mean lifespan of fruit flies. |
| PubMed:Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK-Ay mice. |
| PubMed:Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats. |
| PubMed:Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats. |
| PubMed:In vitro inhibition of 7-ethoxyresorufin-O-deethylase (EROD) and p-nitrophenol hydroxylase (PNPH) activities by sesamin in hepatic microsomes from two fish species. |
| PubMed:Tissue distribution and cytochrome P450 inhibition of sesaminol and its tetrahydrofuranoid metabolites. |
| PubMed:Sesamin modulates gene expression without corresponding effects on fatty acids in Atlantic salmon (Salmo salar L.). |
| PubMed:Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats. |
| PubMed:Interrelated effects of dihomo-γ-linolenic and arachidonic acids, and sesamin on hepatic fatty acid synthesis and oxidation in rats. |
| PubMed:Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.). |
| PubMed:Fatty acids and gene expression responses to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes. |
| PubMed:[Nutritional value of sesame seeds]. |
| PubMed:Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans. |
| PubMed:Interaction of sesamol (3,4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis. |
| PubMed:Estrogenic activities of sesame lignans and their metabolites on human breast cancer cells. |
| PubMed:Sesame seed lignans: potent physiological modulators and possible ingredients in functional foods & nutraceuticals. |
| PubMed:Influence of dietary sesamin, a bioactive compound on fatty acids and expression of some lipid regulating genes in Baltic Atlantic salmon (Salmo salar L.) juveniles. |
| PubMed:Sesamin attenuates intercellular cell adhesion molecule-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice. |
| PubMed:Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells. |
| PubMed:Assessing the neuroprotective effect of antioxidant food factors by application of lipid-derived dopamine modification adducts. |
| PubMed:Sesamin mitigates inflammation and oxidative stress in endothelial cells exposed to oxidized low-density lipoprotein. |
| PubMed:Identification and characterization of sesaminol metabolites in the liver. |
| PubMed:Assessing the neuroprotective effect of antioxidative food factors by application of lipid-derived dopamine modification adducts. |
| PubMed:Lipid metabolism and nutrigenomics - impact of sesame lignans on gene expression profiles and fatty acid oxidation in rat liver. |
| PubMed:Genomics for food functionality and palatability. |
| PubMed:Comparative study of sesame lignans (sesamin, episesamin and sesamolin) affecting gene expression profile and fatty acid oxidation in rat liver. |
| PubMed:Comparison of atmospheric pressure chemical ionization and electrospray ionization mass spectrometry for the detection of lignans from sesame seeds. |
| PubMed:Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. |
| PubMed:Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. |
| PubMed:Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. |
| PubMed:Dietary tocotrienol reduces UVB-induced skin damage and sesamin enhances tocotrienol effects in hairless mice. |
| PubMed:Effect of the form of the sesame-based diet on the absorption of lignans. |
| PubMed:Hydroxymatairesinol and sesaminol act differently on tocopherol concentrations in rats. |
| PubMed:Suppression of ochratoxin biosynthesis by naturally occurring alkaloids. |
| PubMed:Quantitative NMR analysis of a sesamin catechol metabolite in human urine. |
| PubMed:Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. |
| PubMed:Assessing exposure to lignans and their metabolites in humans. |
| PubMed:Nondestructive determination of lignans and lignan glycosides in sesame seeds by near infrared reflectance spectroscopy. |
| PubMed:Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. |
| PubMed:Antioxidant activity and bioactive compounds of tea seed (Camellia oleifera Abel.) oil. |
| PubMed:Beyond vitamin E supplementation: an alternative strategy to improve vitamin E status. |
| PubMed:Dietary sesamin is converted to enterolactone in humans. |
| PubMed:Consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolites in humans. |
| PubMed:Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus. |
| PubMed:A benzenoid from the stem of Acanthopanax senticosus. |
| PubMed:Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats. |
| PubMed:Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. |
| PubMed:Species differences in the physiological activity of dietary lignan (sesamin and episesamin) in affecting hepatic fatty acid metabolism. |
| PubMed:Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes. |
| PubMed:Free radical scavenging behavior of antioxidant compounds of sesame (sesamum indicum L.) in DPPH(*) system. |
| PubMed:Comparative effects of flaxseed and sesame seed on vitamin E and cholesterol levels in rats. |
| PubMed:Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. |
| PubMed:Dietary (+)-catechin and BHT markedly increase alpha-tocopherol concentrations in rats by a tocopherol-omega-hydroxylase-independent mechanism. |
| PubMed:Novel antioxidative metabolites in rat liver with ingested sesamin. |
| PubMed:Comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. |
| PubMed:Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol. |
| PubMed:Dietary manipulations of body fat-reducing potential of conjugated linoleic acid in rats. |
| PubMed:Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. |
| PubMed:Effects of dietary sesame seeds on plasma tocopherol levels. |
| PubMed:Hepatothermic therapy of obesity: rationale and an inventory of resources. |
| PubMed:Effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver. |
| PubMed:Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. |
| PubMed:Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet. |
| PubMed:Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat. |
| PubMed:Dietary defatted sesame flour decreases susceptibility to oxidative stress in hypercholesterolemic rabbits. |
| PubMed:Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. |
| PubMed:Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol. |
| PubMed:Effects of sesamin and alpha-tocopherol, individually or in combination, on the polyunsaturated fatty acid metabolism, chemical mediator production, and immunoglobulin levels in Sprague-Dawley rats. |
| PubMed:Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet. |
| PubMed:Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. |
| PubMed:Sesame seed lignans and gamma-tocopherol act synergistically to produce vitamin E activity in rats. |
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3D/inchi