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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 560.53 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 420.00 °F. TCC ( 215.40 °C. ) (est)
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| logP (o/w): | 5.078 (est) |
| Soluble in: |
| | water, 0.5633 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Physcion 98%
|
| BOC Sciences |
| For experimental / research use only. |
| Physcion >98%
Odor: characteristic Use: Physcion is an anthraquinone from roots of Rheum officinale Baill.It has also shown anti-fungal activity against barley powdery mildew and cucumber powdery mildew, more efficiently in the latter case than treatments with fenarimol and polyoxin B. |
| Coompo |
| For experimental / research use only. |
| Physcione from Plants ≥96%
Odor: characteristic Use: Anthraquinones are components in many medicines of plant origin since they possess a broad spectrum of biological activity including antibacterial, purgative, anti-inflammatory, astringent, antiviral, antioxidant and antifungal properties.
Physcion controls powdery mildew mainly through changing the expression of defence-related genes, and especially enhancing expression of leaf-specific thionin in barley leaves. |
| ExtraSynthese |
| For experimental / research use only. |
| Physcion (HPLC) ≥99%
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Physcione ≥98%
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| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Physcione ≥98.0% (TLC)
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 10 mg/kg
GASTROINTESTINAL: OTHER CHANGES
Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 1342, 1979.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for physcione usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for physcione flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10639 |
| Pubchem (sid): | 134977206 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 9,10- | anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- | | 9,10- | anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- (9CI) | | | anthraquinone, 1,8-dihydroxy-3-methoxy-6-methyl- | | 1,8- | dihydroxy-3-methoxy-6-methyl anthraquinone | | 1,8- | dihydroxy-3-methoxy-6-methyl-9,10-anthracene dione | | 1,8- | dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione | | 1,8- | dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone | | 1,8- | dihydroxy-3-methoxy-6-methyl-anthraquinone | | 1,8- | dihydroxy-3-methoxy-6-methylanthracene-9,10-dione | | 1,8- | dihydroxy-3-methoxy-6-methylanthraquinone | | 1,8- | dihydroxy-3-methyl-6-methoxy-9,10-anthraquinone | | 1,8- | dihydroxy-3-methyl-6-methoxyanthraquinone | | 1,8- | dihydroxy-6-methoxy-3-methylanthracene-9,10-dione | | | emodin 3-methyl ether | | | emodin-3-methyl ether | | | emodin-3-methylether | | | parietin | | | physcion | | | rheochrysidin |
Articles:
| PubMed:Lichen secondary metabolites as DNA-interacting agents. |
| PubMed:Application of an efficient strategy based on liquid-liquid extraction, high-speed counter-current chromatography, and preparative HPLC for the rapid enrichment, separation, and purification of four anthraquinones from Rheum tanguticum. |
| PubMed:Purgative components in rhubarbs: adrenergic receptor inhibitors linked with glucose carriers. |
| PubMed:Antioxidant polyketide phenolic metabolites from the edible mushroom Cortinarius purpurascens. |
| PubMed:Quality assessment of Japanese knotweed (Fallopia japonica) grown on Prince Edward Island as a source of resveratrol. |
| PubMed:Developmental changes in the composition of five anthraquinones from Rheum palmatum as quantified by (1) H-NMR. |
| PubMed:Comparison of laxative and antioxidant activities of raw, processed and fermented Polygoni Multiflori radix. |
| PubMed:Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats. |
| PubMed:Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats. |
| PubMed:A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector. |
| PubMed:A new polymorph of physcion. |
| PubMed:[Chemical constituents of Berchemia lineate]. |
| PubMed:[Determination of four anthraquinones in Sanhuang tablets by QAMS]. |
| PubMed:Enhancement of fluoride activity against Streptococcus mutans biofilms by a substance separated from Polygonum cuspidatum. |
| PubMed:Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines. |
| PubMed:Anthraquinones of Cissus populnea Guill & Perr (Amplidaceae). |
| PubMed:Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica. |
| PubMed:[Chemical constituents of Carya cathayensis and their antitumor bioactivity]. |
| PubMed:A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract. |
| PubMed:[Alkaloids and anthraquinones from branches and leaves of uvaria kurzii]. |
| PubMed:Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata. |
| PubMed:The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L. |
| PubMed:Comparative analyses of chromatographic fingerprints of the roots of Polygonum multiflorum Thunb. and their processed products using RRLC/DAD/ESI-MS(n). |
| PubMed:[Tissue distribution of free anthraquinones in SD rats after orally administered extracts from raw and prepared rhubarbs]. |
| PubMed:Simultaneous determination of eight anthraquinones in Semen Cassiae by HPLC-DAD. |
| PubMed:Sensitivity of Xanthoria parietina to UV-A: role of metabolic modulators. |
| PubMed:Preparative isolation of three anthraquinones from Rumex japonicus by high-speed counter-current chromatography. |
| PubMed:Physiological responses of root-less epiphytic plants to acid rain. |
| PubMed:[Studies on the chemical constituents of radix Boehmeriae]. |
| PubMed:Phytochemical and antioxidant studies of Laurera benguelensis growing in Thailand. |
| PubMed:[Liposomal encapsulation of free anthraquinones in rhizoma et radix rhei and its quality control]. |
| PubMed:[Studies on the chemical constituents of Kalimeris indica]. |
| PubMed:Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid. |
| PubMed:[Chemical constituents of Discocleidion rufescens]. |
| PubMed:A new bianthracene C-arabinopyranoside from Senna septemtrionalis. |
| PubMed:The correlation between bioactive components of Fallopia multiflora root and environmental factors. |
| PubMed:Bioactivity-guided separation of anti-acidogenic substances against Streptococcus mutans UA 159 from Polygonum cuspidatum. |
| PubMed:Physcion, a natural anthraquinone derivative, enhances the gene expression of leaf-specific thionin of barley against Blumeria graminis. |
| PubMed:Qualitative and quantitative analysis of anthraquinone derivatives in rhizomes of tissue culture-raised Rheum emodi Wall. plants. |
| PubMed:Light screening in lichen cortices can be quantified by chlorophyll fluorescence techniques for both reflecting and absorbing pigments. |
| PubMed:Physcion-8-O-beta-D-glucopyranoside enhances the commitment of mouse mesenchymal progenitors into osteoblasts and their differentiation: Possible involvement of signaling pathways to activate BMP gene expression. |
| PubMed:[Effect of processing on the chemical contents and hepatic and renal toxicity of rhubarb studied by canonical correlation analysis]. |
| PubMed:Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae). |
| PubMed:Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components. |
| PubMed:Simultaneous determination of seven components in Qibaomeiran pill by HPLC-DAD. |
| PubMed:Phytochemical investigation of the Australian lichens Ramalina glaucescens and Xanthoria parietina. |
| PubMed:Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. |
| PubMed:Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry. |
| PubMed:Effective constituents in Xiexin Decoction for anti-inflammation. |
| PubMed:Ultrasonic extraction and HPLC determination of anthraquinones, aloe-emodine, emodine, rheine, chrysophanol and physcione, in roots of Polygoni multiflori. |
| PubMed:A new chalcone glycoside from Rhamnus nipalensis. |
| PubMed:Dissociation and metal-binding characteristics of yellow lichen substances suggest a relationship with site preferences of lichens. |
| PubMed:[Study on the chemical constituents of Rhizoma Cyperi]. |
| PubMed:[Studies on chemical constituents and volatile oil of Xiaochengqi decoction]. |
| PubMed:[Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC]. |
| PubMed:Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum. |
| PubMed:[A new qualitative and quantitative analytical method of chromatographic fingerprints: total quantum statistical moment]. |
| PubMed:A new spiroketal from Aspergillus terreus, an endophytic fungus in Opuntia ficusindica Mill. |
| PubMed:[Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini]. |
| PubMed:Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati. |
| PubMed:Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities. |
| PubMed:A new isocoumarin from Hypericum annulatum. |
| PubMed:Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe. |
| PubMed:In situ synthesis of molecularly imprinted polymers on glass microspheres in a column. |
| PubMed:[Application of macroporous resin in purification for effective part from Polygonum cuspidatum]. |
| PubMed:Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system. |
| PubMed:Tolerance of the lichen Xanthoria parietina (L.) Th. Fr. to metal stress. |
| PubMed:Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. |
| PubMed:Synergistic interaction of physcion and chrysophanol on plant powdery mildew. |
| PubMed:Alterations in secondary metabolism of aposymbiotically grown mycobionts of Xanthoria elegans and cultured resynthesis stages. |
| PubMed:[Induction of hairy roots and anthraquinone production in Rheum palmatum]. |
| PubMed:Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata. |
| PubMed:Supercritical CO2 extraction of emodin and physcion from Polygonum cuspidatum and subsequent isolation by semipreparative chromatography. |
| PubMed:[Studies on the chemical constituents in stem rind of Wikstroemia indica]. |
| PubMed:[HPLC fingerprint of Rhizoma Polygoni Cuspidati]. |
| PubMed:[Studies on chemical constituents of hairy root of Cassia obtusifolia]. |
| PubMed:[Simultaneous determination of resveratrol, emodin, chrysophanol, physcion, in root of Polygonam cuspidatum and its extract by HPLC]. |
| PubMed:Annual variation in photo acclimation and photoprotection of the photobiont in the foliose lichen Xanthoria parietina. |
| PubMed:Preparative isolation and purification of five compounds from the Chinese medicinal herb Polygonum cuspidatum Sieb. et Zucc by high-speed counter-current chromatography. |
| PubMed:Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents. |
| PubMed:Determination and locational variations in the quantity of hydroxyanthraquinones and their glycosides in rhizomes of Rheum emodi using high-performance liquid chromatography. |
| PubMed:[Studies on the chemical constituents in herb of Mentha haplocalyx]. |
| PubMed:[Influence of processing rhubarb on it's anthraquinone contents]. |
| PubMed:[Study on the optimal harvesting time of Rumex gmelini by analyzing the contents of principal components]. |
| PubMed:Separation and determination of four active anthraquinones in Chinese herbal preparations by flow injection-capillary electrophoresis. |
| PubMed:Raman spectroscopic analysis of cyanobacterial gypsum halotrophs and relevance for sulfate deposits on Mars. |
| PubMed:[Influence of process methods on contents of chemical component Radix Polygoni Multiflori]. |
| PubMed:The potential of the lichen symbiosis to cope with the extreme conditions of outer space II: germination capacity of lichen ascospores in response to simulated space conditions. |
| PubMed:Antifungal activity of Rubia tinctorum, Rhamnus frangula and Caloplaca cerina. |
| PubMed:[Simultaneous determination of 4 anthraquinones in Kuhuang injection by RP-HPLC]. |
| PubMed:Anti-proliferative lichen compounds with inhibitory activity on 12(S)-HETE production in human platelets. |
| PubMed:[Phenolic compounds isolated from rhizoma of Aster tataricus]. |
| PubMed:Lichen palatability depends on investments in herbivore defence. |
| PubMed:Aspergillus fumigatus CY018, an endophytic fungus in Cynodon dactylon as a versatile producer of new and bioactive metabolites. |
| PubMed:[Studies on the extraction of ingredients from Chinese traditional medicine with CO2 supercritical fluid]. |
| PubMed:The lichens Xanthoria elegans and Cetraria islandica maintain a high protection against UV-B radiation in Arctic habitats. |
| PubMed:Microbial glycosylation of four free anthraquinones by Absidia coerulea. |
| PubMed:Micropropagation of Polygonum multiflorum THUNB and quantitative analysis of the anthraquinones emodin and physcion formed in in vitro propagated shoots and plants. |
| PubMed:[Studies on the chemical constituents of Dendrobium fimbriatum]. |
| PubMed:[Studies on chemical constituents of Bletilla striata (Thunb) Reichb. f]. |
| PubMed:[Studies on the chemical constituents of the stems of Alyxia sinensis (I)]. |
| PubMed:[Study on the quantitative change of anthraquinonoids of Rhei in the preparation of dachengqi]. |
| PubMed:Is parietin a UV-B or a blue-light screening pigment in the lichen Xanthoria parietina? |
| PubMed:[Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang]. |
| PubMed:[Chemical constituents of Rheum wittrochii Lundstr(I)]. |
| PubMed:Cytotoxic principles from Ventilago leiocarpa. |
| PubMed:Determination of pKa values of anthraquinone compounds by capillary electrophoresis. |
| PubMed:Occurrence of emodin, chrysophanol and physcion in vegetables, herbs and liquors. Genotoxicity and anti-genotoxicity of the anthraquinones and of the whole plants. |
| PubMed:Factors affecting the genotoxic potency ranking of natural anthraquinones in mammalian cell culture systems. |
| PubMed:[Isolation and identification of terpenoides and anthraquinones from Euphorbia fischeriana]. |
| PubMed:A tumor cell growth inhibitor from Polygonum hypoleucum Ohwi. |
| PubMed:Sequestration of lichen compounds by lichen-feeding members of the Arctiidae (Lepidoptera). |
| PubMed:Sequestration of lichen compounds by three species of terrestrial snails. |
| PubMed:Phytochemical investigation of Rumex luminiastrum. |
| PubMed:Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system. |
| PubMed:Chemical Constituents of the Lichen Ramalina hierrensis. |
| PubMed:[Chemical components of radix Polygoni multiflori and its preparation]. |
| PubMed:[Isolation and identification of metabolites of physcion in rats and mice In vivo and In vitro]. |
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3D/inchi