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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 237.00 to 238.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.008000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 233.00 °F. TCC ( 111.80 °C. ) (est)
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| logP (o/w): | 0.013 (est) |
| Soluble in: |
| | water, 4.916e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 2-hydroxyisovaleric acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 2-hydroxyisovaleric acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | butanoic acid, 2-hydroxy-3-methyl- | | 2- | hydroxy-3-methyl butanoic acid | | 2- | hydroxy-3-methyl butyric acid | | 2- | hydroxy-3-methylbutanoic acid | | 2- | hydroxy-3-methylbutyric acid |
Articles:
| PubMed:Sanctolide A, a 14-membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta (SAG 74.79). |
| PubMed:Experimental and theoretical studies of vacuum-ultraviolet electronic circular dichroism of hydroxy acids in aqueous solution. |
| PubMed:Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro. |
| PubMed:Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain. |
| PubMed:Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana. |
| PubMed:Proton HR-MAS NMR spectroscopic characterization of metabolites in various human organ tissues: pancreas, brain and liver from trauma cases. |
| PubMed:Two step derivatization for the analyses of organic, amino acids and glycines on filter paper plasma by GC-MS/SIM. |
| PubMed:Low-abundance kutznerides from Kutzneria sp. 744. |
| PubMed:Absolute configuration of the creatonotines and callimorphines, two classes of arctiid-specific pyrrolizidine alkaloids. |
| PubMed:Exceptional chiral recognition of racemic carboxylic acids by calix[4]arenes bearing optically pure alpha,beta-amino alcohol groups. |
| PubMed:Disturbances of valine metabolism in patients with peroxisomal biogenesis disorders. |
| PubMed:Enniatin synthetase is a monomer with extended structure: evidence for an intramolecular reaction mechanism. |
| PubMed:Stimulation of lipid peroxidation in vitro in rat brain by the metabolites accumulating in maple syrup urine disease. |
| PubMed:Enantiomeric purity determination of malic acid in apple juices by multi-beam circular dichroism detection. |
| PubMed:Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. |
| PubMed:Characteristic urine organic acid profile in peroxisomal biogenesis disorders. |
| PubMed:Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography. |
| PubMed:Immunosuppressive effects of organic acids accumulating in patients with maple syrup urine disease. |
| PubMed:Bacterial expression of catalytically active fragments of the multifunctional enzyme enniatin synthetase. |
| PubMed:Identification of 3-hydroxyisovalerylcarnitine in the urine of a patient with multiple carboxylase deficiency. |
| PubMed:Effects of birth asphyxia on urinary organic acid excretion. |
| PubMed:In vitro biosynthesis of [Thr2,Leu5,D-Hiv8,Leu10]-cyclosporin, a cyclosporin-related peptolide, with immunosuppressive activity by a multienzyme polypeptide. |
| PubMed:In vitro biosynthesis of [Thr2, Leu5, D-Hiv8, Leu10]cyclosporin, a cyclosporin-related immunosuppressive peptolide. |
| PubMed:[The growth of rats in renal compensatory adaptation in feeding with a supplemented diet of hydroxy-analogs of essential amino acids]. |
| PubMed:Physiological studies on the growth and utilization of sugars by Listeria species. |
| PubMed:New conjugated urinary metabolites in intermediate type maple syrup urine disease. |
| PubMed:Monoclonal antibodies to the multienzyme enniatin synthetase. Production and use in structural studies. |
| PubMed:Biotinidase deficiency: metabolites in CSF. |
| PubMed:Hydroxycarboxylic and oxocarboxylic acids in urine: products from branched-chain amino acid degradation and from ketogenesis. |
| PubMed:Siderophore production by Proteus mirabilis. |
| PubMed:Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. |
| PubMed:Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. |
| PubMed:Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats. |
| PubMed:Propionyl-CoA carboxylase deficiency: case report, effect of low-protein diet and identification of 3-oxo-2-methylvaleric acid 3-hydroxy-2-methylvaleric acid, and maleic acid in urine. |
| PubMed:The occurrence of 2-hydroxyisovaleric acid in patients with lactic acidosis and ketoacidosis. |
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2-Hydroxy-3-methylbutyric acid is a metabolite found in the urine of patients with Phenylketonuria (PMID 7978272), Methylmalonic acidemia, Propionic acidemia, 3-Ketothiolase deficiency, Isovaleric acidemia, 3-Methylcrotonylglycemia, 3-Hydroxy-3-methylglutaric acidemia, Multiple carboxylase deficiency, Glutaric aciduria, Ornithine transcarbamylase deficiency, glyceroluria, Tyrosinemia type 1, Galactosemia, and Maple syrup urine disease (PMID 11048741) [HMDB]
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