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Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow powder (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 494.40 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 380.00 °F. TCC ( 193.50 °C. ) (est)
|
| logP (o/w): | 2.760 (est) |
| Soluble in: |
| | water, 149.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for 7,8-dihydroxyflavone usage levels up to: | | | not for fragrance use.
|
| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 28 |
| Click here to view publication 28 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | - |
| beverages(nonalcoholic): | 5.00000 | 15.00000 |
| beverages(alcoholic): | 5.00000 | 15.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | 100.00000 | 1000.00000 |
| condiments / relishes: | 10.00000 | 30.00000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | 5.00000 | 15.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | 10.00000 | 30.00000 |
| hard candy: | 50.00000 | 200.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | 5.00000 | 15.00000 |
| jams / jellies: | - | - |
| meat products: | 10.00000 | 30.00000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | 10.00000 | 30.00000 |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | 30.00000 | 100.00000 |
| snack foods: | 50.00000 | 200.00000 |
| soft candy: | 50.00000 | 200.00000 |
| soups: | 10.00000 | 20.00000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 7,8-dihydroxy-2-phenyl- | | 7,8- | dihydroxy-2-phenyl-4-benzopyrone | | 7,8- | dihydroxy-2-phenyl-4H-1-benzopyran-4-one | | 7,8- | dihydroxy-2-phenyl-4H-chromen-4-one | | 7,8- | dihydroxy-2-phenyl-chromen-4-one | | 7,8- | dihydroxy-2-phenylchromen-4-one | | 7,8- | dihydroxy-flavone |
Articles:
| PubMed:7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome. |
| PubMed:Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor. |
| PubMed:7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K/Akt and JNK pathways. |
| PubMed:Behavior of the potential antitumor V(IV)O complexes formed by flavonoid ligands. 1. Coordination modes and geometry in solution and at the physiological pH. |
| PubMed:Methylation and subsequent glycosylation of 7,8-dihydroxyflavone. |
| PubMed:Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference. |
| PubMed:Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. |
| PubMed:7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. |
| PubMed:7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. |
| PubMed:Effect of 7, 8-dihydroxyflavone on the up-regulation of Nrf2-mediated heme oxygenase-1 expression in hamster lung fibroblasts. |
| PubMed:7,8-Dihydroxyflavone attenuates the release of pro-inflammatory mediators and cytokines in lipopolysaccharide-stimulated BV2 microglial cells through the suppression of the NF-κB and MAPK signaling pathways. |
| PubMed:7,8-Dihydroxyflavone protects human keratinocytes against oxidative stress-induced cell damage via the ERK and PI3K/Akt-mediated Nrf2/HO-1 signaling pathways. |
| PubMed:Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. |
| PubMed:Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. |
| PubMed:7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction. |
| PubMed:Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone. |
| PubMed:Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity. |
| PubMed:Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one. |
| PubMed:7,8-Dihydroxyflavone suppresses oxidative stress-induced base modification in DNA via induction of the repair enzyme 8-oxoguanine DNA glycosylase-1. |
| PubMed:Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. |
| PubMed:7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice. |
| PubMed:7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats. |
| PubMed:Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves. |
| PubMed:7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. |
| PubMed:7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine. |
| PubMed:Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists. |
| PubMed:Small molecules activating TrkB receptor for treating a variety of CNS disorders. |
| PubMed:Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. |
| PubMed:Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs. |
| PubMed:Thyroxin treatment protects against white matter injury in the immature brain via brain-derived neurotrophic factor. |
| PubMed:Probing the ability of presynaptic tyrosine kinase receptors to regulate striatal dopamine dynamics. |
| PubMed:Activation of BDNF signaling prevents the return of fear in female mice. |
| PubMed:Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine. |
| PubMed:Modulatory effects of the novel TrkB receptor agonist 7,8-dihydroxyflavone on synaptic transmission and intrinsic neuronal excitability in mouse visual cortex in vitro. |
| PubMed:7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathways. |
| PubMed:TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia. |
| PubMed:Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. |
| PubMed:O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. |
| PubMed:Apoptosis induction of human leukemia U937 cells by 7,8-dihydroxyflavone hydrate through modulation of the Bcl-2 family of proteins and the MAPKs signaling pathway. |
| PubMed:Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning. |
| PubMed:Influence of glucose on the human serum albumin-flavone interaction and their antioxidant activity. |
| PubMed:Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. |
| PubMed:Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. |
| PubMed:Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus. |
| PubMed:Activation of TrkB by 7,8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. |
| PubMed:7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. |
| PubMed:7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation. |
| PubMed:Fear extinction and BDNF: translating animal models of PTSD to the clinic. |
| PubMed:7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells. |
| PubMed:The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. |
| PubMed:7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. |
| PubMed:Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. |
| PubMed:Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins. |
| PubMed:7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. |
| PubMed:Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. |
| PubMed:Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. |
| PubMed:Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. |
| PubMed:7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. |
| PubMed:Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. |
| PubMed:A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. |
| PubMed:Characterization of an O-methyltransferase from Streptomyces avermitilis MA-4680. |
| PubMed:[Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase]. |
| PubMed:A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. |
| PubMed:Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. |
| PubMed:Acidity of hydroxyl groups: an overlooked influence on antiradical properties of flavonoids. |
| PubMed:Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. |
| PubMed:Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone. |
| PubMed:Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. |
| PubMed:Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells. |
| PubMed:Flavonoids: structural requirements for antiproliferative activity on breast cancer cells. |
| PubMed:Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes. |
| PubMed:Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II). |
| PubMed:Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. |
| PubMed:Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. |
| PubMed:Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. |
| PubMed:Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase. |
| PubMed:Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids. |
| PubMed:Effects of phenolic compounds on bromobenzene-mediated hepatotoxicity in mice. |
| PubMed:Effect of various flavonoids on lysosomes subjected to an oxidative or an osmotic stress. |
| PubMed:Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII. |
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3D/inchi